Peringatan Keamanan

Symptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acute renal failure may occur rarely following overdose. Respiratory depression and metabolic acidosis have also been reported following overdose with certain NSAIDs.

Fenoprofen

DB00573

small molecule approved

Deskripsi

An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.

Struktur Molekul 2D

Berat 242.2699
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Plasma half-life is approximately 3 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed under fasting conditions, and peak plasma levels of 50 µg/mL are achieved within 2 hours after oral administration of 600 mg doses.

Metabolisme

About 90% of a single oral dose is eliminated within 24 hours as fenoprofen glucuronide and 4'-hydroxyfenoprofen glucuronide, the major urinary metabolites of fenoprofen.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

1393 Data
Amlodipine Fenoprofen may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Fenoprofen.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Fenoprofen.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Fenoprofen.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Fenoprofen.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Fenoprofen.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Fenoprofen.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Fenoprofen.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Fenoprofen.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Fenoprofen.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Fenoprofen.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Fenoprofen.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Fenoprofen.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Fenoprofen.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Fenoprofen.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Fenoprofen.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Fenoprofen.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Fenoprofen.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Fenoprofen.
Lisuride The risk or severity of hypertension can be increased when Fenoprofen is combined with Lisuride.
Linezolid The risk or severity of hypertension can be increased when Fenoprofen is combined with Linezolid.
Metaraminol The risk or severity of hypertension can be increased when Fenoprofen is combined with Metaraminol.
Furazolidone The risk or severity of hypertension can be increased when Fenoprofen is combined with Furazolidone.
Epinephrine The risk or severity of hypertension can be increased when Fenoprofen is combined with Epinephrine.
Thioridazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Thioridazine.
Ergotamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Ergotamine.
Nicergoline The risk or severity of hypertension can be increased when Fenoprofen is combined with Nicergoline.
Sufentanil The risk or severity of hypertension can be increased when Fenoprofen is combined with Sufentanil.
Methoxamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Methoxamine.
Risperidone The risk or severity of hypertension can be increased when Fenoprofen is combined with Risperidone.
Tranylcypromine The risk or severity of hypertension can be increased when Fenoprofen is combined with Tranylcypromine.
Isoflurane The risk or severity of hypertension can be increased when Fenoprofen is combined with Isoflurane.
Propiomazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Propiomazine.
Alfentanil The risk or severity of hypertension can be increased when Fenoprofen is combined with Alfentanil.
Minaprine The risk or severity of hypertension can be increased when Fenoprofen is combined with Minaprine.
Orciprenaline The risk or severity of hypertension can be increased when Fenoprofen is combined with Orciprenaline.
Propofol The risk or severity of hypertension can be increased when Fenoprofen is combined with Propofol.
Phenmetrazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Phenmetrazine.
Trifluoperazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Trifluoperazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Fenoprofen is combined with Pseudoephedrine.
Benzphetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Benzphetamine.
Ritodrine The risk or severity of hypertension can be increased when Fenoprofen is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Fenoprofen is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Fenoprofen is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Fenoprofen is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Fenoprofen is combined with Diethylpropion.
Salmeterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Salmeterol.
Naratriptan The risk or severity of hypertension can be increased when Fenoprofen is combined with Naratriptan.
Formoterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Formoterol.
Frovatriptan The risk or severity of hypertension can be increased when Fenoprofen is combined with Frovatriptan.
Methoxyflurane The risk or severity of hypertension can be increased when Fenoprofen is combined with Methoxyflurane.
Selegiline The risk or severity of hypertension can be increased when Fenoprofen is combined with Selegiline.
Ergoloid mesylate The risk or severity of hypertension can be increased when Fenoprofen is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Fenoprofen is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Fenoprofen is combined with Dutasteride.
Halothane The risk or severity of hypertension can be increased when Fenoprofen is combined with Halothane.
Moclobemide The risk or severity of hypertension can be increased when Fenoprofen is combined with Moclobemide.
Pergolide The risk or severity of hypertension can be increased when Fenoprofen is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Fenoprofen is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Fenoprofen is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Fenoprofen is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Fenoprofen is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Fenoprofen is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Fenoprofen is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Fenoprofen is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Fenoprofen is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Fenoprofen is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Fenoprofen is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Fenoprofen is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Fenoprofen is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Fenoprofen is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Fenoprofen is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Fenoprofen is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Fenoprofen is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Fenoprofen is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Fenoprofen is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Fenoprofen is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Fenoprofen is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Fenoprofen is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Fenoprofen is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Fenoprofen is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Fenoprofen is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Fenoprofen is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Fenoprofen is combined with Iloperidone.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1
Peroxisome proliferator-activated receptor alpha PPARA
Peroxisome proliferator-activated receptor gamma PPARG

Referensi & Sumber

Synthesis reference: Marshall, W.S.; U.S. Patent 3,600,437; August 17, 1971; assigned to Eli Lilly and Company.

Contoh Produk & Brand

Produk: 46 • International brands: 8
Produk
  • Fenoprofen
    Capsule • 400 mg/1 • Oral • US • Approved
  • Fenoprofen
    Capsule • 400 mg/1 • Oral • US • Approved
  • Fenoprofen
    Capsule • 400 mg/1 • Oral • US • Approved
  • Fenoprofen
    Capsule • 400 mg/1 • Oral • US • Approved
  • Fenoprofen
    Capsule • 200 mg/1 • Oral • US • Approved
  • Fenoprofen Calcium
    Tablet, film coated • 600 mg/1 • Oral • US • Generic • Approved
  • Fenoprofen Calcium
    Capsule • 200 mg/1 • Oral • US • Approved
  • Fenoprofen Calcium
    Capsule • 400 mg/1 • Oral • US • Approved
Menampilkan 8 dari 46 produk.
International Brands
  • Feilin — Hengshan Pharmaceutical
  • Fenopron — Typharm
  • Fepron — Sheng Chung Tang
  • Kimpron — Daewoong
  • Nalgésic — Sciencex
  • Nonsic — Hasan
  • Noprofen — Panion & BF
  • Trandor — Biolab

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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