First synthesized by Janssen Pharmaceuticals in 1955, cinnarizine is an anti-histaminic drug mainly used for the control of vestibular disorders and motion sickness. Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. Combination use of cinnarizine with other nootropics, such as piracetam resulted in enhanced effect of boosting brain oxygen supply.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ceritinib | Cinnarizine may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Cinnarizine may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Cinnarizine. |
| Deferasirox | The serum concentration of Cinnarizine can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Cinnarizine can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Cinnarizine can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Cinnarizine can be decreased when it is combined with Teriflunomide. |
| Cimetidine | The serum concentration of Cinnarizine can be increased when it is combined with Cimetidine. |
| Clopidogrel | The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Cinnarizine. |
| Efavirenz | The serum concentration of Cinnarizine can be decreased when it is combined with Efavirenz. |
| Melatonin | The therapeutic efficacy of Cinnarizine can be decreased when used in combination with Melatonin. |
| Nafcillin | The therapeutic efficacy of Cinnarizine can be decreased when used in combination with Nafcillin. |
| Nitroprusside | Cinnarizine may increase the hypotensive activities of Nitroprusside. |
| Benzylpenicilloyl polylysine | Cinnarizine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent. |
| Betahistine | The therapeutic efficacy of Betahistine can be decreased when used in combination with Cinnarizine. |
| Dantrolene | The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Cinnarizine. |
| Lithium citrate | The risk or severity of adverse effects can be increased when Cinnarizine is combined with Lithium citrate. |
| Lithium carbonate | The risk or severity of adverse effects can be increased when Cinnarizine is combined with Lithium carbonate. |
| Lithium hydroxide | The risk or severity of adverse effects can be increased when Cinnarizine is combined with Lithium hydroxide. |
| Mirabegron | The serum concentration of Cinnarizine can be increased when it is combined with Mirabegron. |
| Boceprevir | The serum concentration of Cinnarizine can be increased when it is combined with Boceprevir. |
| Abiraterone | The serum concentration of Cinnarizine can be increased when it is combined with Abiraterone. |
| Cyproterone acetate | The metabolism of Cinnarizine can be increased when combined with Cyproterone acetate. |
| Amphetamine | Amphetamine may decrease the sedative activities of Cinnarizine. |
| Phentermine | Phentermine may decrease the sedative activities of Cinnarizine. |
| Pseudoephedrine | Pseudoephedrine may decrease the sedative activities of Cinnarizine. |
| Benzphetamine | Benzphetamine may decrease the sedative activities of Cinnarizine. |
| Diethylpropion | Diethylpropion may decrease the sedative activities of Cinnarizine. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the sedative activities of Cinnarizine. |
| Mephentermine | Mephentermine may decrease the sedative activities of Cinnarizine. |
| MMDA | MMDA may decrease the sedative activities of Cinnarizine. |
| Midomafetamine | Midomafetamine may decrease the sedative activities of Cinnarizine. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Cinnarizine. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Cinnarizine. |
| Tenamfetamine | Tenamfetamine may decrease the sedative activities of Cinnarizine. |
| Chlorphentermine | Chlorphentermine may decrease the sedative activities of Cinnarizine. |
| Methylenedioxyethamphetamine | Methylenedioxyethamphetamine may decrease the sedative activities of Cinnarizine. |
| Dextroamphetamine | Dextroamphetamine may decrease the sedative activities of Cinnarizine. |
| Metamfetamine | Metamfetamine may decrease the sedative activities of Cinnarizine. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the sedative activities of Cinnarizine. |
| Ritobegron | Ritobegron may decrease the sedative activities of Cinnarizine. |
| Mephedrone | Mephedrone may decrease the sedative activities of Cinnarizine. |
| Methoxyphenamine | Methoxyphenamine may decrease the sedative activities of Cinnarizine. |
| Gepefrine | Gepefrine may decrease the sedative activities of Cinnarizine. |
| 2,5-Dimethoxy-4-ethylthioamphetamine | 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Cinnarizine. |
| Phendimetrazine | Phendimetrazine may decrease the sedative activities of Cinnarizine. |
| Carteolol | Cinnarizine may increase the arrhythmogenic activities of Carteolol. |
| Metipranolol | Cinnarizine may increase the arrhythmogenic activities of Metipranolol. |
| Xylometazoline | Cinnarizine may increase the arrhythmogenic activities of Xylometazoline. |
| Fasudil | Cinnarizine may increase the arrhythmogenic activities of Fasudil. |
| Tropisetron | Cinnarizine may increase the arrhythmogenic activities of Tropisetron. |
| Spiradoline | Cinnarizine may increase the arrhythmogenic activities of Spiradoline. |
| Tiracizine | Cinnarizine may increase the arrhythmogenic activities of Tiracizine. |
| Ethacizine | Cinnarizine may increase the arrhythmogenic activities of Ethacizine. |
| Hydroquinine | Cinnarizine may increase the arrhythmogenic activities of Hydroquinine. |
| Bioallethrin | Cinnarizine may increase the arrhythmogenic activities of Bioallethrin. |
| Fosfructose | Cinnarizine may increase the arrhythmogenic activities of Fosfructose. |
| Hydroquinidine | Cinnarizine may increase the arrhythmogenic activities of Hydroquinidine. |
| SOR-C13 | Cinnarizine may increase the arrhythmogenic activities of SOR-C13. |
| Digoxin | Digoxin may increase the arrhythmogenic activities of Cinnarizine. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Cinnarizine. |
| Deslanoside | Cinnarizine may increase the arrhythmogenic activities of Deslanoside. |
| Cymarin | Cinnarizine may increase the arrhythmogenic activities of Cymarin. |
| Metildigoxin | Cinnarizine may increase the arrhythmogenic activities of Metildigoxin. |
| Acetyldigoxin | Cinnarizine may increase the arrhythmogenic activities of Acetyldigoxin. |
| Disopyramide | Disopyramide may increase the arrhythmogenic activities of Cinnarizine. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Cinnarizine. |
| Bepridil | Cinnarizine may increase the arrhythmogenic activities of Bepridil. |
| Terodiline | Cinnarizine may increase the arrhythmogenic activities of Terodiline. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Cinnarizine. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Cinnarizine. |
| Atropine | Cinnarizine may increase the arrhythmogenic activities of Atropine. |
| Adenosine | Cinnarizine may increase the arrhythmogenic activities of Adenosine. |
| Levosimendan | Cinnarizine may increase the arrhythmogenic activities of Levosimendan. |
| Nifedipine | Cinnarizine may increase the arrhythmogenic activities of Nifedipine. |
| Prenylamine | Cinnarizine may increase the arrhythmogenic activities of Prenylamine. |
| Fluspirilene | Cinnarizine may increase the arrhythmogenic activities of Fluspirilene. |
| Azimilide | Cinnarizine may increase the arrhythmogenic activities of Azimilide. |
| Tedisamil | Cinnarizine may increase the arrhythmogenic activities of Tedisamil. |
| Nilvadipine | Cinnarizine may increase the arrhythmogenic activities of Nilvadipine. |
| Fendiline | Cinnarizine may increase the arrhythmogenic activities of Fendiline. |
| Eperisone | Cinnarizine may increase the arrhythmogenic activities of Eperisone. |
| Melperone | Cinnarizine may increase the arrhythmogenic activities of Melperone. |
| Benidipine | Cinnarizine may increase the arrhythmogenic activities of Benidipine. |
| Simendan | Cinnarizine may increase the arrhythmogenic activities of Simendan. |
| Otilonium | Cinnarizine may increase the arrhythmogenic activities of Otilonium. |
| Nizofenone | Cinnarizine may increase the arrhythmogenic activities of Nizofenone. |
| Bunaftine | Cinnarizine may increase the arrhythmogenic activities of Bunaftine. |
| Lorcainide | Cinnarizine may increase the arrhythmogenic activities of Lorcainide. |
| Penfluridol | Cinnarizine may increase the arrhythmogenic activities of Penfluridol. |
| Dexverapamil | Cinnarizine may increase the arrhythmogenic activities of Dexverapamil. |
| Isradipine | Isradipine may increase the arrhythmogenic activities of Cinnarizine. |
| Trimethadione | Trimethadione may increase the arrhythmogenic activities of Cinnarizine. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Cinnarizine. |
| Lamotrigine | Lamotrigine may increase the arrhythmogenic activities of Cinnarizine. |
| Verapamil | Cinnarizine may increase the arrhythmogenic activities of Verapamil. |
| Losartan | Cinnarizine may increase the arrhythmogenic activities of Losartan. |
| Moricizine | Cinnarizine may increase the arrhythmogenic activities of Moricizine. |
| Levomenthol | Cinnarizine may increase the arrhythmogenic activities of Levomenthol. |
| Zonisamide | Cinnarizine may increase the arrhythmogenic activities of Zonisamide. |