Peringatan Keamanan

Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.Label An overdose is generally managed through supportive treatment as diuresis, dialysis, hemodialysis, and charcoal hemoperfusion are not well studied in this case.Label

The oral median lethal dose of cephalexin in rats is >5000 mg/kg. The oral LD50 in a monkey is >1g/kg and the lowest dose causing a toxic effect in humans is 14mg/kg.MSDS

Cephalexin has not been shown to be harmful in pregnancy and is not associated with teratogeniticy.Label Cephalexin is present in breast milk, though infants may be exposed to <1% of the dose given to the mother.Label The effects of breast milk exposure to cephalexin have not been established and so caution must be exercised and the risk and benefit of cephalexin use in breastfeeding must be weighed.Label

Cephalexin has not been studied for carcinogenicity or mutagenicity.Label Cephalexin has no affect on fertility in rats.Label

Cephalexin

DB00567

small molecule approved investigational vet_approved

Deskripsi

Cephalexin is the first of the first generation cephalosporins.A179071,A179074 This antibiotic contains a beta lactam and a dihydrothiazide.A179071 Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.A179083,Label Cephalexin was approved by the FDA on 4 January 1971.L6547

Struktur Molekul 2D

Berat 347.389
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half life of cephalexin is 49.5 minutes in a fasted state and 76.5 minutes with food though these times were not significantly different in the study.[A179032]
Volume Distribusi 5.2-5.8L.[A179068]
Klirens (Clearance) Clearance from one subject was 376mL/min.[A179032]

Absorpsi

Well absorbed from the upper gastrointestinal tract with nearly 100% oral bioavailability.A179032,A179035 Cephalexin is not absorbed in the stomach but is absorbed in the upper intestine.A179065 Patients taking 250mg of cephalexin reach a maximum plasma concentration of 7.7mcg/mL and patients taking 500mg reach 12.3mcg/mL.A179026

Metabolisme

Cephalexin is not metabolized in the body.A179029,Label,L6550,L6553

Rute Eliminasi

Cephalexin is over 90% excreted in the urine after 6 hoursA179026 by glomerular filtration and tubular secretionLabel,L6550,L6553 with a mean urinary recovery of 99.3%.A179032 Cephalexin is unchanged in the urine.A179026,A179029,A179032

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

1333 Data
Phenytoin The metabolism of Cephalexin can be increased when combined with Phenytoin.
Fosphenytoin The metabolism of Cephalexin can be increased when combined with Fosphenytoin.
Probenecid The serum concentration of Cephalexin can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cephalexin is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cephalexin.
Tenofovir disoproxil Cephalexin may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Cephalexin.
Tenofovir Cephalexin may increase the nephrotoxic activities of Tenofovir.
Aspartame The excretion of Cephalexin can be decreased when combined with Aspartame.
Pravastatin The excretion of Cephalexin can be decreased when combined with Pravastatin.
Aminohippuric acid The excretion of Cephalexin can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Cephalexin can be decreased when combined with Lansoprazole.
Zidovudine The excretion of Cephalexin can be decreased when combined with Zidovudine.
Succinic acid The excretion of Succinic acid can be decreased when combined with Cephalexin.
Citrulline The excretion of Citrulline can be decreased when combined with Cephalexin.
Cefdinir The excretion of Cefdinir can be decreased when combined with Cephalexin.
Leucovorin The excretion of Leucovorin can be decreased when combined with Cephalexin.
Fluorescein The excretion of Fluorescein can be decreased when combined with Cephalexin.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Cephalexin.
Quinapril The excretion of Quinapril can be decreased when combined with Cephalexin.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Cephalexin.
Famotidine The excretion of Famotidine can be decreased when combined with Cephalexin.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Cephalexin.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Cephalexin.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Cephalexin.
Captopril The excretion of Captopril can be decreased when combined with Cephalexin.
Tazobactam The excretion of Tazobactam can be decreased when combined with Cephalexin.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cephalexin.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Cephalexin.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Cephalexin.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Cephalexin.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Cephalexin.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Cephalexin.
Avibactam The excretion of Avibactam can be decreased when combined with Cephalexin.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Cephalexin.
Silibinin The excretion of Silibinin can be decreased when combined with Cephalexin.
Relebactam The excretion of Relebactam can be decreased when combined with Cephalexin.
Enalapril The excretion of Cephalexin can be decreased when combined with Enalapril.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Cephalexin.
Esomeprazole The excretion of Cephalexin can be decreased when combined with Esomeprazole.
Minocycline The excretion of Cephalexin can be decreased when combined with Minocycline.
Novobiocin The excretion of Cephalexin can be decreased when combined with Novobiocin.
Melatonin The excretion of Cephalexin can be decreased when combined with Melatonin.
Ouabain The excretion of Cephalexin can be decreased when combined with Ouabain.
Liotrix The excretion of Cephalexin can be decreased when combined with Liotrix.
Cilastatin The excretion of Cephalexin can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Cephalexin can be decreased when combined with trans-2-hydroxycinnamic acid.
Benzoic acid The excretion of Cephalexin can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Cephalexin can be decreased when combined with Caprylic acid.
Ataluren The excretion of Cephalexin can be decreased when combined with Ataluren.
Teriflunomide The excretion of Cephalexin can be decreased when combined with Teriflunomide.
Dolutegravir The excretion of Cephalexin can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Cephalexin can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Cephalexin can be decreased when combined with Cabotegravir.
Letermovir The metabolism of Cephalexin can be decreased when combined with Letermovir.
Pradigastat The excretion of Cephalexin can be decreased when combined with Pradigastat.
Cefotiam The excretion of Cephalexin can be decreased when combined with Cefotiam.
Indomethacin The excretion of Cephalexin can be decreased when combined with Indomethacin.
Cefalotin The excretion of Cephalexin can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Cephalexin can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Cephalexin can be decreased when combined with Cefotaxime.
Piroxicam The excretion of Cephalexin can be decreased when combined with Piroxicam.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Cephalexin.
Pantoprazole The excretion of Cephalexin can be decreased when combined with Pantoprazole.
Liothyronine The excretion of Cephalexin can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Cephalexin can be decreased when combined with Conjugated estrogens.
Piperacillin The excretion of Piperacillin can be decreased when combined with Cephalexin.
Trifluridine The excretion of Trifluridine can be decreased when combined with Cephalexin.
Allopurinol The excretion of Allopurinol can be decreased when combined with Cephalexin.
Cimetidine The excretion of Cephalexin can be decreased when combined with Cimetidine.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Cephalexin.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Cephalexin.
Tetracycline The excretion of Tetracycline can be decreased when combined with Cephalexin.
Estradiol The excretion of Estradiol can be decreased when combined with Cephalexin.
Acyclovir The excretion of Acyclovir can be decreased when combined with Cephalexin.
Cefaclor The excretion of Cefaclor can be decreased when combined with Cephalexin.
Ranitidine The excretion of Ranitidine can be decreased when combined with Cephalexin.
Bumetanide The excretion of Bumetanide can be decreased when combined with Cephalexin.
Acetylsalicylic acid The excretion of Cephalexin can be decreased when combined with Acetylsalicylic acid.
Ganciclovir The excretion of Cephalexin can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Cephalexin can be decreased when combined with Ketoprofen.
Ibuprofen The excretion of Cephalexin can be decreased when combined with Ibuprofen.
Cefadroxil The excretion of Cephalexin can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Cephalexin can be decreased when combined with Ceftriaxone.
Gemfibrozil The excretion of Cephalexin can be decreased when combined with Gemfibrozil.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Cephalexin.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Cephalexin.
Topiroxostat The excretion of Cephalexin can be decreased when combined with Topiroxostat.
Doripenem The excretion of Doripenem can be decreased when combined with Cephalexin.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Cephalexin.
Diclofenac The excretion of Cephalexin can be decreased when combined with Diclofenac.
Phenylbutazone The excretion of Cephalexin can be decreased when combined with Phenylbutazone.
Salicylic acid The excretion of Cephalexin can be decreased when combined with Salicylic acid.
Cefamandole The excretion of Cephalexin can be decreased when combined with Cefamandole.
Cefazolin The excretion of Cefazolin can be decreased when combined with Cephalexin.
Cefoperazone The excretion of Cephalexin can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Ceftizoxime can be decreased when combined with Cephalexin.
Cefacetrile The excretion of Cefacetrile can be decreased when combined with Cephalexin.
Cefaloridine The excretion of Cefaloridine can be decreased when combined with Cephalexin.
Favipiravir The excretion of Cephalexin can be decreased when combined with Favipiravir.

Target Protein

Penicillin-binding protein 3 pbp3
Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 1b pbp1b
Penicillin-binding protein 2B penA
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Synthesis reference: Peter Faarup, "Method of preparing a sparingly soluble complex of cephalexin." U.S. Patent US4003896, issued May, 1975.
Artikel (PubMed)
  • PMID: 4388601
    Thornhill TS, Levison ME, Johnson WD, Kaye D: In vitro antimicrobial activity and human pharmacology of cephalexin, a new orally absorbed cephalosporin C antibiotic. Appl Microbiol. 1969 Mar;17(3):457-61.
  • PMID: 5811391
    Sullivan HR, Billings RE, McMahon RE: Metabolism of cephalexin-14C in mice and in rats. J Antibiot (Tokyo). 1969 May;22(5):195-200.
  • PMID: 5348475
    Gower PE, Dash CH: Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic. Br J Pharmacol. 1969 Nov;37(3):738-47. doi: 10.1111/j.1476-5381.1969.tb08513.x.
  • PMID: 4398634
    Henning C, Kallings LO, Lidman K, Sterner G: Studies of absorption, excretion, antibacterial and clinical effect of cephalexin. Scand J Infect Dis. 1970;2(2):131-8.
  • PMID: 6364086
    Griffith RS: The pharmacology of cephalexin. Postgrad Med J. 1983;59 Suppl 5:16-27.
  • PMID: 848940
    Pfeffer M, Jackson A, Ximenes J, de Menezes JP: Comparative human oral clinical pharmacology of cefadroxil, cephalexin, and cephradine. Antimicrob Agents Chemother. 1977 Feb;11(2):331-8. doi: 10.1128/aac.11.2.331.
  • PMID: 3542485
    Tanrisever B, Santella PJ: Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine. Drugs. 1986;32 Suppl 3:1-16. doi: 10.2165/00003495-198600323-00003.
  • PMID: 17292577
    Sader HS, Jacobs MR, Fritsche TR: Review of the spectrum and potency of orally administered cephalosporins and amoxicillin/clavulanate. Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):5S-12S. doi: 10.1016/j.diagmicrobio.2006.12.014. Epub 2007 Feb 9.
Menampilkan 8 dari 10 artikel.

Contoh Produk & Brand

Produk: 500 • International brands: 34
Produk
  • Apo-cephalex
    Tablet • 500 mg • Oral • Canada • Generic • Approved
  • Apo-cephalex
    Tablet • 250 mg • Oral • Canada • Generic • Approved
  • Asn-cephalexin
    Powder, for suspension • 125 mg / 5 mL • Oral • Canada • Approved
  • Asn-cephalexin
    Powder, for suspension • 250 mg / 5 mL • Oral • Canada • Approved
  • Auro-cephalexin
    Tablet • 250 mg • Oral • Canada • Generic • Approved
  • Auro-cephalexin
    Tablet • 500 mg • Oral • Canada • Generic • Approved
  • Auro-cephalexin
    Powder, for suspension • 125 mg / 5 mL • Oral • Canada • Generic • Approved
  • Auro-cephalexin
    Powder, for suspension • 250 mg / 5 mL • Oral • Canada • Generic • Approved
Menampilkan 8 dari 500 produk.
International Brands
  • Alcephin — Alembic
  • Alexin — Dabur
  • Alsporin — Renata
  • Cefadin — Life
  • Cefalin — BioFemme
  • Ceforal — Teva
  • Cefovit — Vitamed
  • Celexin — Atlantic
  • Cephin — General Drugs House
  • Ceporexin — Investi

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