Zanamivir

DB00558

small molecule approved investigational

Deskripsi

A guanido-neuraminic acid that is used to inhibit neuraminidase.

Struktur Molekul 2D

Berat 332.3098
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.5-5.1 hours
Volume Distribusi -
Klirens (Clearance) * 2.5 - 10.9 L/h [Following oral inhalation 10 mg] * 5.3 L/h [Normal renal function receiving IV single dose of 4 mg or 2 mg] * 2.7 L/h [Patients with mild and moderate renal impairement receiving IV single dose of 4 mg or 2 mg] * 0.8 L/h [Patients with severe renal impairement receiving IV single dose of 4 mg or 2 mg]

Absorpsi

Absolute bioavailability is very low following oral administration (2%). Following oral inhalation, bioavailability is 4% to 17%.

Metabolisme

Not metabolized

Rute Eliminasi

It is excreted unchanged in the urine with excretion of a single dose completed within 24 hours. Unabsorbed drug is excreted in the feces.Zanamivir is renally excreted as unchanged drug.

Interaksi Obat

741 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Zanamivir which could result in a higher serum level.

Target Protein

Neuraminidase NA
Neuraminidase NA
Sialidase-2 NEU2

Referensi & Sumber

Synthesis reference: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Ashwini Amol Sawant, Sanoj Thoppil, "Process for Preparing Zanamivir and Intermediates for Use in the Process." U.S. Patent US20110257418, issued October 20, 2011.
Artikel (PubMed)
  • PMID: 4362431
    Meindl P, Bodo G, Palese P, Schulman J, Tuppy H: Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. Virology. 1974 Apr;58(2):457-63.
  • PMID: 8502295
    von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin B, Van Phan T, Smythe ML, White HF, Oliver SW, et al.: Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature. 1993 Jun 3;363(6428):418-23.
  • PMID: 18694948
    Hata K, Koseki K, Yamaguchi K, Moriya S, Suzuki Y, Yingsakmongkon S, Hirai G, Sodeoka M, von Itzstein M, Miyagi T: Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. Antimicrob Agents Chemother. 2008 Oct;52(10):3484-91. doi: 10.1128/AAC.00344-08. Epub 2008 Aug 11.
  • PMID: 18582202
    Sugaya N, Tamura D, Yamazaki M, Ichikawa M, Kawakami C, Kawaoka Y, Mitamura K: Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children. Clin Infect Dis. 2008 Aug 1;47(3):339-45. doi: 10.1086/589748.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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