Peringatan Keamanan

Symptoms of overdose include drowsiness, nausea, stomach pain, and/or vomiting.

Piroxicam

DB00554

small molecule approved investigational

Deskripsi

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.

Struktur Molekul 2D

Berat 331.346
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 30 to 86 hours
Volume Distribusi * 0.14 L/kg
Klirens (Clearance) -

Absorpsi

Well absorbed following oral administration.

Metabolisme

Renal

Rute Eliminasi

Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a piroxicam dose is excreted unchanged. However, a substantial portion of piroxicam elimination occurs by hepatic metabolism. Piroxicam is excreted into human milk.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food.

Interaksi Obat

1669 Data
Amlodipine The metabolism of Piroxicam can be decreased when combined with Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Piroxicam.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Piroxicam.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Piroxicam.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Piroxicam.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Piroxicam.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Piroxicam.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Piroxicam.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Piroxicam.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Piroxicam.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Piroxicam.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Piroxicam.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Piroxicam.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Piroxicam.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Piroxicam.
Doxapram The risk or severity of hypertension can be increased when Piroxicam is combined with Doxapram.
Atropine The risk or severity of hypertension can be increased when Piroxicam is combined with Atropine.
Lisuride The risk or severity of hypertension can be increased when Piroxicam is combined with Lisuride.
Linezolid The risk or severity of hypertension can be increased when Piroxicam is combined with Linezolid.
Metaraminol The risk or severity of hypertension can be increased when Piroxicam is combined with Metaraminol.
Furazolidone The risk or severity of hypertension can be increased when Piroxicam is combined with Furazolidone.
Ergotamine The risk or severity of hypertension can be increased when Piroxicam is combined with Ergotamine.
Nicergoline The risk or severity of hypertension can be increased when Piroxicam is combined with Nicergoline.
Sufentanil The risk or severity of hypertension can be increased when Piroxicam is combined with Sufentanil.
Methoxamine The risk or severity of hypertension can be increased when Piroxicam is combined with Methoxamine.
Risperidone The risk or severity of hypertension can be increased when Piroxicam is combined with Risperidone.
Isoflurane The risk or severity of hypertension can be increased when Piroxicam is combined with Isoflurane.
Propiomazine The risk or severity of hypertension can be increased when Piroxicam is combined with Propiomazine.
Alfentanil The risk or severity of hypertension can be increased when Piroxicam is combined with Alfentanil.
Minaprine The risk or severity of hypertension can be increased when Piroxicam is combined with Minaprine.
Orciprenaline The risk or severity of hypertension can be increased when Piroxicam is combined with Orciprenaline.
Phenmetrazine The risk or severity of hypertension can be increased when Piroxicam is combined with Phenmetrazine.
Trifluoperazine The risk or severity of hypertension can be increased when Piroxicam is combined with Trifluoperazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Piroxicam is combined with Pseudoephedrine.
Benzphetamine The risk or severity of hypertension can be increased when Piroxicam is combined with Benzphetamine.
Ritodrine The risk or severity of hypertension can be increased when Piroxicam is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Piroxicam is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Piroxicam is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Piroxicam is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Piroxicam is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Piroxicam is combined with Diethylpropion.
Naratriptan The risk or severity of hypertension can be increased when Piroxicam is combined with Naratriptan.
Frovatriptan The risk or severity of hypertension can be increased when Piroxicam is combined with Frovatriptan.
Ergoloid mesylate The risk or severity of hypertension can be increased when Piroxicam is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Piroxicam is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Piroxicam is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Piroxicam is combined with Dutasteride.
Pergolide The risk or severity of hypertension can be increased when Piroxicam is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Piroxicam is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Piroxicam is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Piroxicam is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Piroxicam is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Piroxicam is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Piroxicam is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Piroxicam is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Piroxicam is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Piroxicam is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Piroxicam is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Piroxicam is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Piroxicam is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Piroxicam is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Piroxicam is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Piroxicam is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Piroxicam is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Piroxicam is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Piroxicam is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Piroxicam is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Piroxicam is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Piroxicam is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Piroxicam is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Piroxicam is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Piroxicam is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Piroxicam is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Piroxicam is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Piroxicam is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Piroxicam is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Piroxicam is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Piroxicam is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Piroxicam is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Piroxicam is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Piroxicam is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Piroxicam is combined with 1-benzylimidazole.
Nialamide The risk or severity of hypertension can be increased when Piroxicam is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Piroxicam is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Piroxicam is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Piroxicam is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Piroxicam is combined with Iloperidone.
Indacaterol The risk or severity of hypertension can be increased when Piroxicam is combined with Indacaterol.
Rotigotine The risk or severity of hypertension can be increased when Piroxicam is combined with Rotigotine.
Amibegron The risk or severity of hypertension can be increased when Piroxicam is combined with Amibegron.
Naluzotan The risk or severity of hypertension can be increased when Piroxicam is combined with Naluzotan.
Cariprazine The risk or severity of hypertension can be increased when Piroxicam is combined with Cariprazine.
Mianserin The risk or severity of hypertension can be increased when Piroxicam is combined with Mianserin.
Pizotifen The risk or severity of hypertension can be increased when Piroxicam is combined with Pizotifen.
Solabegron The risk or severity of hypertension can be increased when Piroxicam is combined with Solabegron.
Asenapine The risk or severity of hypertension can be increased when Piroxicam is combined with Asenapine.
Esmirtazapine The risk or severity of hypertension can be increased when Piroxicam is combined with Esmirtazapine.
Vilazodone The risk or severity of hypertension can be increased when Piroxicam is combined with Vilazodone.
Nitrous oxide The risk or severity of hypertension can be increased when Piroxicam is combined with Nitrous oxide.
Xylometazoline The risk or severity of hypertension can be increased when Piroxicam is combined with Xylometazoline.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1

Referensi & Sumber

Synthesis reference: Paul D. Weeks, "3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam." U.S. Patent US4376204, issued April, 1982.

Contoh Produk & Brand

Produk: 122 • International brands: 10
Produk
  • Alti-piroxicam-cap 10mg
    Capsule • 10 mg / cap • Oral • Canada • Generic • Approved
  • Alti-piroxicam-cap 20mg
    Capsule • 20 mg / cap • Oral • Canada • Generic • Approved
  • Apo Piroxicam Cap 10mg
    Capsule • 10 mg • Oral • Canada • Generic • Approved
  • Apo Piroxicam Cap 20mg
    Capsule • 20 mg • Oral • Canada • Generic • Approved
  • Dom-piroxicam
    Suppository • 10 mg • Rectal • Canada • Generic • Approved
  • Dom-piroxicam
    Suppository • 20 mg • Rectal • Canada • Generic • Approved
  • Dom-piroxicam
    Capsule • 20 mg • Oral • Canada • Generic • Approved
  • Dom-piroxicam
    Capsule • 10 mg • Oral • Canada • Generic • Approved
Menampilkan 8 dari 122 produk.
International Brands
  • Bruxicam
  • Dolonex
  • Erazon
  • Geldène
  • Improntal
  • Roxam — Bosnalijek
  • Roxiden
  • Sasulen
  • Solocalm
  • Trast

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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