Peringatan Keamanan

Topically applied desoximetasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).

Desoximetasone

DB00547

small molecule approved

Deskripsi

A topical anti-inflammatory glucocorticoid used in dermatoses, skin allergies, psoriasis, etc.

Struktur Molekul 2D

Berat 376.4617
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life of the material was 15 ± 2 hours (for urine) and 17 ± 2 hours (for feces) between the third and fifth trial day.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.

Metabolisme

Metabolized, primarily in the liver, and then excreted by the kidneys.

Rute Eliminasi

Corticosteroids are bound to plasma proteins in varying degrees, are metabolized primarily in the liver and excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.Pharmacokinetic studies in men with Desoximetasone Cream USP, 0.25% with tagged desoximetasone showed a total of 5.2% ± 2.9% excretion in urine (4.1% ± 2.3%) and feces (1.1% ± 0.6%)

Interaksi Obat

877 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Desoximetasone.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Desoximetasone.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Desoximetasone.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Desoximetasone.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Desoximetasone.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Desoximetasone.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Desoximetasone.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Desoximetasone.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Desoximetasone.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Desoximetasone.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Desoximetasone.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Desoximetasone.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Desoximetasone.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Desoximetasone.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Desoximetasone.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Desoximetasone.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Desoximetasone.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Desoximetasone.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Desoximetasone.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Desoximetasone.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Desoximetasone.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Desoximetasone.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Desoximetasone.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Desoximetasone.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Desoximetasone.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Desoximetasone.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Desoximetasone.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Desoximetasone.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Desoximetasone.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Desoximetasone.
Cladribine Desoximetasone may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Desoximetasone.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Desoximetasone.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Desoximetasone.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Desoximetasone.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Desoximetasone.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Desoximetasone.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Desoximetasone.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Desoximetasone.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Desoximetasone.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Desoximetasone.
Vinorelbine The risk or severity of adverse effects can be increased when Vinorelbine is combined with Desoximetasone.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Desoximetasone.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Desoximetasone.
Sorafenib The risk or severity of adverse effects can be increased when Sorafenib is combined with Desoximetasone.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Desoximetasone.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Desoximetasone.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Desoximetasone.
Betamethasone The risk or severity of adverse effects can be increased when Betamethasone is combined with Desoximetasone.
Teniposide The risk or severity of adverse effects can be increased when Teniposide is combined with Desoximetasone.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Desoximetasone.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Desoximetasone.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Desoximetasone.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Desoximetasone.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Desoximetasone.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Desoximetasone.
Cyclophosphamide The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Desoximetasone.
Vincristine The risk or severity of adverse effects can be increased when Vincristine is combined with Desoximetasone.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Desoximetasone.
Propylthiouracil The risk or severity of adverse effects can be increased when Desoximetasone is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Desoximetasone is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Desoximetasone is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Desoximetasone is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Desoximetasone is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Desoximetasone is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Desoximetasone is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Desoximetasone is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Desoximetasone is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Desoximetasone is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Desoximetasone is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Desoximetasone is combined with Methimazole.
Mometasone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Mometasone.
Etoposide The risk or severity of adverse effects can be increased when Desoximetasone is combined with Etoposide.
Dacarbazine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Desoximetasone is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Desoximetasone is combined with Sirolimus.
Azacitidine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Desoximetasone is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Desoximetasone is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Desoximetasone is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Desoximetasone is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Desoximetasone is combined with Busulfan.
Clobetasol propionate The risk or severity of adverse effects can be increased when Desoximetasone is combined with Clobetasol propionate.
Mycophenolic acid The risk or severity of adverse effects can be increased when Desoximetasone is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Desoximetasone is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Desoximetasone is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Desoximetasone is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Desoximetasone is combined with Melphalan.
Fluocinonide The risk or severity of adverse effects can be increased when Desoximetasone is combined with Fluocinonide.

Target Protein

Estrogen-related receptor gamma ESRRG
Glucocorticoid receptor NR3C1
Steroid hormone receptor ERR2 ESRRB
Steroid hormone receptor ERR1 ESRRA

Referensi & Sumber

Synthesis reference: Kieslich, K., Kerb, U. and Raspe, G.; U S . Patent 3,232,839; February 1,1966; assigned to Schering AG, Germany.

Contoh Produk & Brand

Produk: 87 • International brands: 4
Produk
  • Desoxi Cream 0.05%
    Cream • 0.05 % • Topical • Canada • Approved
  • Desoxi Cream 0.25%
    Cream • 0.25 % • Topical • Canada • Approved
  • Desoxi Gel 0.05%
    Gel • 0.05 % • Topical • Canada • Approved
  • Desoximetasone
    Gel • 0.5 mg/1g • Topical • US • Generic • Approved
  • Desoximetasone
    Cream • 2.5 mg/1g • Topical • US • Generic • Approved
  • Desoximetasone
    Ointment • 2.5 mg/1g • Topical • US • Generic • Approved
  • Desoximetasone
    Cream • 2.5 mg/1g • Topical • US • Generic • Approved
  • Desoximetasone
    Gel • 0.5 mg/1g • Topical • US • Generic • Approved
Menampilkan 8 dari 87 produk.
International Brands
  • Esperson — sanofi-aventis
  • Flubason — sanofi-aventis
  • Topicort LP — sanofi-aventis
  • Topisolon — sanofi-aventis

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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