Peringatan Keamanan

Signs of overdose may include muscle weakness, ataxia, dysarthria and particularly in children paradoxical excitement. In more severe cases diminished reflexes, confusion, and coma may ensue.

Adinazolam

DB00546

small molecule experimental

Deskripsi

Adinazolam (Deracyn®) is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative, and antidepressant properties. Adinazolam was first developed to enhance the antidepressant effects of alprazolam. It has never been approved by the FDA for clinical use.

Struktur Molekul 2D

Berat 351.833
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Less than 3 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

The drug primarily undergoes hepatic metabolism to form the main metabolite N-desmethyladinazolam, alpha-hydroxyalprazolam, and estazolam.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

816 Data
Buprenorphine Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Hydrocodone Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Magnesium sulfate The therapeutic efficacy of Adinazolam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Adinazolam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Mirtazapine Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Orphenadrine Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Pramipexole Adinazolam may increase the sedative activities of Pramipexole.
Ropinirole Adinazolam may increase the sedative activities of Ropinirole.
Rotigotine Adinazolam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Adinazolam.
Suvorexant Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Thalidomide Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Adinazolam is combined with Clozapine.
Methadone Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Olanzapine The risk or severity of adverse effects can be increased when Adinazolam is combined with Olanzapine.
Sodium oxybate Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Adinazolam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Adinazolam can be increased when used in combination with Yohimbine.
Dicoumarol The risk or severity of adverse effects can be increased when Adinazolam is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Adinazolam is combined with Phenindione.
Coumarin The risk or severity of adverse effects can be increased when Adinazolam is combined with Coumarin.
Tioclomarol The risk or severity of adverse effects can be increased when Adinazolam is combined with Tioclomarol.
Warfarin The risk or severity of adverse effects can be increased when Adinazolam is combined with Warfarin.
Phenprocoumon The risk or severity of adverse effects can be increased when Adinazolam is combined with Phenprocoumon.
Acenocoumarol The risk or severity of adverse effects can be increased when Adinazolam is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Adinazolam is combined with 4-hydroxycoumarin.
(R)-warfarin The risk or severity of adverse effects can be increased when Adinazolam is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Adinazolam is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Adinazolam is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Adinazolam is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Adinazolam is combined with Diphenadione.
(S)-Warfarin The risk or severity of adverse effects can be increased when Adinazolam is combined with (S)-Warfarin.
Ethanol Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Zimelidine The risk or severity of adverse effects can be increased when Adinazolam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Adinazolam is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Adinazolam is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Adinazolam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Adinazolam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Adinazolam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Adinazolam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Adinazolam is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Adinazolam is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Adinazolam is combined with Sibutramine.
Escitalopram The risk or severity of adverse effects can be increased when Adinazolam is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Adinazolam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Adinazolam is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Adinazolam is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Adinazolam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Adinazolam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Adinazolam is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Adinazolam.
Propiomazine The risk or severity of CNS depression can be increased when Adinazolam is combined with Propiomazine.
Nicardipine The metabolism of Adinazolam can be decreased when combined with Nicardipine.
Zopiclone The risk or severity of adverse effects can be increased when Adinazolam is combined with Zopiclone.
Caffeine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Caffeine.
Dyphylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Mercaptopurine.
Oxtriphylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Adinazolam can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Adinazolam can be decreased when used in combination with 7,9-Dimethylguanine.
Xanthine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Xanthine.
7-Deazaguanine The therapeutic efficacy of Adinazolam can be decreased when used in combination with 7-Deazaguanine.
Guanine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Guanine.
9-Methylguanine The therapeutic efficacy of Adinazolam can be decreased when used in combination with 9-Methylguanine.
Peldesine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Peldesine.
Hypoxanthine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Hypoxanthine.
9-Deazaguanine The therapeutic efficacy of Adinazolam can be decreased when used in combination with 9-Deazaguanine.
Propentofylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Propentofylline.
Valomaciclovir The therapeutic efficacy of Adinazolam can be decreased when used in combination with Valomaciclovir.
3-isobutyl-1-methyl-7H-xanthine The therapeutic efficacy of Adinazolam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
Uric acid The therapeutic efficacy of Adinazolam can be decreased when used in combination with Uric acid.
Doxofylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Doxofylline.
6-O-benzylguanine The therapeutic efficacy of Adinazolam can be decreased when used in combination with 6-O-benzylguanine.
Lisofylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Lisofylline.
Lobucavir The therapeutic efficacy of Adinazolam can be decreased when used in combination with Lobucavir.
Cafedrine The therapeutic efficacy of Adinazolam can be decreased when used in combination with Cafedrine.
Theodrenaline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Theodrenaline.
Bamifylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Bamifylline.
Proxyphylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Proxyphylline.
Acefylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Acefylline.
Etamiphylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Etamiphylline.
Pentifylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Pentifylline.
Bufylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Bufylline.
Bromotheophylline The therapeutic efficacy of Adinazolam can be decreased when used in combination with Bromotheophylline.

Target Protein

Translocator protein TSPO
GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 6320036
    Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82.
  • PMID: 6148400
    Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8.
  • PMID: 2867497
    File SE, Pellow S: Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites. Neurosci Lett. 1985 Oct 24;61(1-2):115-9.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Deracyn — Upjohn

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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