Toxic manifestations of amoxapine overdosage differ significantly from those of other tricyclic antidepressants. Serious cardiovascular effects are seldom if ever observed. However, CNS effects, particularly grand mal convulsions, occur frequently, and treatment should be directed primarily toward prevention or control of seizures. Status epilepticus may develop and constitutes a neurologic emergency. Coma and acidosis are other serious complications of substantial amoxapine overdosage in some cases. Renal failure may develop two to five days after toxic overdose in patients who may appear otherwise recovered. Acute tubular necrosis with rhabdomuolysis and myolobinurla is the most common renal complication in such cases. This reaction probably occurs in less than 5% of overdose cases, and typically in those who have experienced multiple seizures.
Amoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Valsartan | Amoxapine may decrease the antihypertensive activities of Valsartan. |
| Remikiren | Amoxapine may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Amoxapine may decrease the antihypertensive activities of Torasemide. |
| Guanadrel | Amoxapine may decrease the antihypertensive activities of Guanadrel. |
| Olmesartan | Amoxapine may decrease the antihypertensive activities of Olmesartan. |
| Nitroprusside | Amoxapine may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Amoxapine may decrease the antihypertensive activities of Minoxidil. |
| Fosinopril | Amoxapine may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Amoxapine may decrease the antihypertensive activities of Trandolapril. |
| Benazepril | Amoxapine may decrease the antihypertensive activities of Benazepril. |
| Bosentan | Amoxapine may decrease the antihypertensive activities of Bosentan. |
| Enalapril | Amoxapine may decrease the antihypertensive activities of Enalapril. |
| Cyclothiazide | Amoxapine may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Amoxapine may decrease the antihypertensive activities of Candoxatril. |
| Eplerenone | Amoxapine may decrease the antihypertensive activities of Eplerenone. |
| Lisinopril | Amoxapine may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Amoxapine may decrease the antihypertensive activities of Nitroglycerin. |
| Cryptenamine | Amoxapine may decrease the antihypertensive activities of Cryptenamine. |
| Candesartan cilexetil | Amoxapine may decrease the antihypertensive activities of Candesartan cilexetil. |
| Eprosartan | Amoxapine may decrease the antihypertensive activities of Eprosartan. |
| Quinapril | Amoxapine may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Amoxapine may decrease the antihypertensive activities of Telmisartan. |
| Irbesartan | Amoxapine may decrease the antihypertensive activities of Irbesartan. |
| Deserpidine | Amoxapine may decrease the antihypertensive activities of Deserpidine. |
| Diazoxide | Amoxapine may decrease the antihypertensive activities of Diazoxide. |
| Guanethidine | Amoxapine may decrease the antihypertensive activities of Guanethidine. |
| Epoprostenol | Amoxapine may decrease the antihypertensive activities of Epoprostenol. |
| Hydralazine | Amoxapine may decrease the antihypertensive activities of Hydralazine. |
| Cilazapril | Amoxapine may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Amoxapine may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Amoxapine may decrease the antihypertensive activities of Spirapril. |
| Tienilic acid | Amoxapine may decrease the antihypertensive activities of Tienilic acid. |
| Sitaxentan | Amoxapine may decrease the antihypertensive activities of Sitaxentan. |
| Diethylnorspermine | Amoxapine may decrease the antihypertensive activities of Diethylnorspermine. |
| Pinacidil | Amoxapine may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Amoxapine may decrease the antihypertensive activities of Temocapril. |
| Riociguat | Amoxapine may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Amoxapine may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Amoxapine may decrease the antihypertensive activities of Aliskiren. |
| Rauwolfia serpentina root | Amoxapine may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Amoxapine may decrease the antihypertensive activities of Enalaprilat. |
| Angiotensin 1-7 | Amoxapine may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Amoxapine may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Amoxapine may decrease the antihypertensive activities of BQ-123. |
| Dihydralazine | Amoxapine may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Amoxapine may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Amoxapine may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Amoxapine may decrease the antihypertensive activities of Delapril. |
| Vincamine | Amoxapine may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Amoxapine may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Amoxapine may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Amoxapine may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Amoxapine may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Amoxapine may decrease the antihypertensive activities of Cadralazine. |
| Bietaserpine | Amoxapine may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Amoxapine may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Amoxapine may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Amoxapine may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Amoxapine may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Amoxapine may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Amoxapine may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Amoxapine may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Amoxapine may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Amoxapine may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Amoxapine may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Amoxapine may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Amoxapine may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Amoxapine may decrease the antihypertensive activities of Furosemide. |
| Captopril | Amoxapine may decrease the antihypertensive activities of Captopril. |
| Ambrisentan | Amoxapine may decrease the antihypertensive activities of Ambrisentan. |
| Selexipag | Amoxapine may decrease the antihypertensive activities of Selexipag. |
| Ramipril | Amoxapine may decrease the antihypertensive activities of Ramipril. |
| Perindopril | Amoxapine may decrease the antihypertensive activities of Perindopril. |
| Levamlodipine | Amoxapine may decrease the antihypertensive activities of Levamlodipine. |
| Buthiazide | Amoxapine may decrease the antihypertensive activities of Buthiazide. |
| Azilsartan medoxomil | Amoxapine may decrease the antihypertensive activities of Azilsartan medoxomil. |
| Buprenorphine | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
| Hydrocodone | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Magnesium sulfate | The therapeutic efficacy of Amoxapine can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
| Orphenadrine | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
| Rotigotine | Amoxapine may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Amoxapine. |
| Sodium oxybate | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
| Thalidomide | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Aclidinium | The risk or severity of adverse effects can be increased when Amoxapine is combined with Aclidinium. |
| Mianserin | Mianserin may increase the anticholinergic activities of Amoxapine. |
| Mirabegron | The risk or severity of urinary retention can be increased when Amoxapine is combined with Mirabegron. |
| Potassium chloride | The risk or severity of gastrointestinal ulceration can be increased when Amoxapine is combined with Potassium chloride. |
| Pramlintide | The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Amoxapine. |