Peringatan Keamanan

The most common adverse effects include headache, dizziness, fatigue, somnolence, postural dizziness, nausea, and coughFDA Label,A839.

The most likely symptom of overdosage is severe hypotensionFDA Label.

Benazepril

DB00542

small molecule approved investigational

Deskripsi

Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failureA838,A837. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitorA836.

Struktur Molekul 2D

Berat 424.4895
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half life of the prodrug benazepril is 2.7±8.5h[A836]. The half life of the active metabolite benazeprilat is 22.3±9.2h[A836] The accumulation half life of benazepril is 10 to 11 hours[FDA Label][A836].
Volume Distribusi The final population pharmacokinetic model in one study estimated the volume of distribution to be 203±69.9L[F4169].
Klirens (Clearance) The final population pharmacokinetic model of one study estimates the clearance to be 129±30.0L[F4169].

Absorpsi

Bioavailability of oral dosing is 3% to 4% in horsesA176450. In humans at least 37% of oral benazepril is absorbed and reaches peak plasma concentration in 0.5 hours to 1 hourA176453. Other studies have shown a peak plasma concentration at a median of 1.5 hoursA836.

Metabolisme

Cleavage of the ester group (primarily in the liver) converts benazepril to its active metabolite, benazeprilatFDA Label. Benazepril and benazeprilat are conjugated to glucuronic acid prior to urinary excretionFDA Label.

Rute Eliminasi

Benazepril and benazeprilat are cleared predominantly by renal excretion in healthy subjects with normal renal functionFDA Label. Nonrenal (i.e., biliary) excretion accounts for approximately 11%-12% of benazeprilat excretion in healthy subjectsFDA Label.

Interaksi Makanan

2 Data
  • 1. Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
  • 2. Take with or without food. Food slows the rate of absorption but not the extent.

Interaksi Obat

904 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Benazepril is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Benazepril is combined with Levodopa.
Risperidone Benazepril may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Benazepril.
Amifostine Benazepril may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Benazepril.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Benazepril.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Benazepril.
Obinutuzumab Benazepril may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Benazepril.
Rituximab Benazepril may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Benazepril.
Phentermine Phentermine may decrease the antihypertensive activities of Benazepril.
Midodrine Midodrine may decrease the antihypertensive activities of Benazepril.
Eletriptan Eletriptan may decrease the antihypertensive activities of Benazepril.
Isoetharine Isoetharine may decrease the antihypertensive activities of Benazepril.
Methysergide Methysergide may decrease the antihypertensive activities of Benazepril.
Cabergoline Cabergoline may decrease the antihypertensive activities of Benazepril.
Atomoxetine Atomoxetine may decrease the antihypertensive activities of Benazepril.
Etomidate Etomidate may decrease the antihypertensive activities of Benazepril.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Benazepril.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Benazepril.
Amitriptyline Amitriptyline may decrease the antihypertensive activities of Benazepril.
Protriptyline Protriptyline may decrease the antihypertensive activities of Benazepril.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Benazepril.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Benazepril.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Benazepril.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Benazepril.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Benazepril.
Promazine Promazine may decrease the antihypertensive activities of Benazepril.
Droperidol Droperidol may decrease the antihypertensive activities of Benazepril.
Buspirone Buspirone may decrease the antihypertensive activities of Benazepril.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Benazepril.
Amoxapine Amoxapine may decrease the antihypertensive activities of Benazepril.
Doxapram Doxapram may decrease the antihypertensive activities of Benazepril.
Atropine Atropine may decrease the antihypertensive activities of Benazepril.
Lisuride Lisuride may decrease the antihypertensive activities of Benazepril.
Metaraminol Metaraminol may decrease the antihypertensive activities of Benazepril.
Trazodone Trazodone may decrease the antihypertensive activities of Benazepril.
Epinephrine Epinephrine may decrease the antihypertensive activities of Benazepril.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Benazepril.
Ergotamine Ergotamine may decrease the antihypertensive activities of Benazepril.
Nicergoline Nicergoline may decrease the antihypertensive activities of Benazepril.
Methoxamine Methoxamine may decrease the antihypertensive activities of Benazepril.
Trimipramine Trimipramine may decrease the antihypertensive activities of Benazepril.
Propiomazine Propiomazine may decrease the antihypertensive activities of Benazepril.
Alfentanil Alfentanil may decrease the antihypertensive activities of Benazepril.
Fentanyl Fentanyl may decrease the antihypertensive activities of Benazepril.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Benazepril.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Benazepril.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Benazepril.
Dobutamine Dobutamine may decrease the antihypertensive activities of Benazepril.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Benazepril.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Benazepril.
Ritodrine Ritodrine may decrease the antihypertensive activities of Benazepril.
Terbutaline Terbutaline may decrease the antihypertensive activities of Benazepril.
Flupentixol Flupentixol may decrease the antihypertensive activities of Benazepril.
Bitolterol Bitolterol may decrease the antihypertensive activities of Benazepril.
Quinidine Quinidine may decrease the antihypertensive activities of Benazepril.
Almotriptan Almotriptan may decrease the antihypertensive activities of Benazepril.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Benazepril.
Salmeterol Salmeterol may decrease the antihypertensive activities of Benazepril.
Naratriptan Naratriptan may decrease the antihypertensive activities of Benazepril.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Benazepril.
Formoterol Formoterol may decrease the antihypertensive activities of Benazepril.
Dopamine Dopamine may decrease the antihypertensive activities of Benazepril.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Benazepril.
Albuterol Salbutamol may decrease the antihypertensive activities of Benazepril.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Benazepril.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Benazepril.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Benazepril.
Arbutamine Arbutamine may decrease the antihypertensive activities of Benazepril.
Dutasteride Dutasteride may decrease the antihypertensive activities of Benazepril.
Doxepin Doxepin may decrease the antihypertensive activities of Benazepril.
Nefazodone Nefazodone may decrease the antihypertensive activities of Benazepril.
Desipramine Desipramine may decrease the antihypertensive activities of Benazepril.
Pergolide Pergolide may decrease the antihypertensive activities of Benazepril.
Finasteride Finasteride may decrease the antihypertensive activities of Benazepril.
Ergometrine Ergometrine may decrease the antihypertensive activities of Benazepril.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Benazepril.
Paliperidone Paliperidone may decrease the antihypertensive activities of Benazepril.
Arformoterol Arformoterol may decrease the antihypertensive activities of Benazepril.
Fenoterol Fenoterol may decrease the antihypertensive activities of Benazepril.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Benazepril.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Benazepril.
Ephedrine Ephedrine may decrease the antihypertensive activities of Benazepril.
Mephentermine Mephentermine may decrease the antihypertensive activities of Benazepril.
Procaterol Procaterol may decrease the antihypertensive activities of Benazepril.
Yohimbine Yohimbine may decrease the antihypertensive activities of Benazepril.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Benazepril.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Benazepril.
Bambuterol Bambuterol may decrease the antihypertensive activities of Benazepril.
MMDA MMDA may decrease the antihypertensive activities of Benazepril.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Benazepril.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Benazepril.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Benazepril.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Benazepril.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Benazepril.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Benazepril.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Benazepril.

Target Protein

Angiotensin-converting enzyme ACE

Referensi & Sumber

Synthesis reference: Wei-Hong Tseng, "ASYMMETRIC SYNTHESIS OF A KEY INTERMEDIATE FOR MAKING BENAZEPRIL AND ANALOGUES THEREOF." U.S. Patent US20020183515, issued December 05, 2002.
Artikel (PubMed)
  • PMID: 1893642
    Gengo FM, Brady E: The pharmacokinetics of benazepril relative to other ACE inhibitors. Clin Cardiol. 1991 Aug;14(8 Suppl 4):IV44-50; discussion IV51-5.
  • PMID: 16407508
    Hou FF, Zhang X, Zhang GH, Xie D, Chen PY, Zhang WR, Jiang JP, Liang M, Wang GB, Liu ZR, Geng RW: Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40.
  • PMID: 17498126
    Ishimitsu T, Akashiba A, Kameda T, Takahashi T, Ohta S, Yoshii M, Minami J, Ono H, Numabe A, Matsuoka H: Benazepril slows progression of renal dysfunction in patients with non-diabetic renal disease. Nephrology (Carlton). 2007 Jun;12(3):294-8.
  • PMID: 1893640
    MacNab M, Mallows S: Safety profile of benazepril in essential hypertension. Clin Cardiol. 1991 Aug;14(8 Suppl 4):IV33-7; discussion IV51-5.
  • PMID: 9328608
    Szekacs B, Vajo Z, Dachman W: Effect of ACE inhibition by benazepril, enalapril and captopril on chronic and post exercise proteinuria. Acta Physiol Hung. 1996;84(4):361-7.
  • PMID: 28371693
    Serrano-Rodriguez JM, Gomez-Diez M, Esgueva M, Castejon-Riber C, Mena-Bravo A, Priego-Capote F, Ayala N, Caballero JMS, Munoz A: Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses. Res Vet Sci. 2017 Oct;114:117-122. doi: 10.1016/j.rvsc.2017.03.016. Epub 2017 Mar 28.
  • PMID: 1720384
    Balfour JA, Goa KL: Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure. Drugs. 1991 Sep;42(3):511-39. doi: 10.2165/00003495-199142030-00008.

Contoh Produk & Brand

Produk: 636 • International brands: 4
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Menampilkan 8 dari 636 produk.
International Brands
  • Briem — Pierre Fabre (France)
  • Cibacen — Novartis (Belgium, Philippines, Switzerland, Turkey), Meda (Denmark, Germany, Greece, Ireland, Italy, Netherlands, Spain)
  • Cibacen WS
  • Cibacene — Meda (France)

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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