LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Succinic acid | The excretion of Succinic acid can be decreased when combined with Guanidine. |
| Citrulline | The excretion of Citrulline can be decreased when combined with Guanidine. |
| Pravastatin | The excretion of Pravastatin can be decreased when combined with Guanidine. |
| Oseltamivir | The excretion of Oseltamivir can be decreased when combined with Guanidine. |
| Cefotiam | The excretion of Cefotiam can be decreased when combined with Guanidine. |
| Conjugated estrogens | The excretion of Conjugated estrogens can be decreased when combined with Guanidine. |
| Tenofovir disoproxil | The excretion of Tenofovir disoproxil can be decreased when combined with Guanidine. |
| Piperacillin | The excretion of Piperacillin can be decreased when combined with Guanidine. |
| Indomethacin | The excretion of Indomethacin can be decreased when combined with Guanidine. |
| Aminohippuric acid | The excretion of Aminohippuric acid can be decreased when combined with Guanidine. |
| Trifluridine | The excretion of Trifluridine can be decreased when combined with Guanidine. |
| Allopurinol | The excretion of Allopurinol can be decreased when combined with Guanidine. |
| Zidovudine | The excretion of Zidovudine can be decreased when combined with Guanidine. |
| Cefdinir | The excretion of Cefdinir can be decreased when combined with Guanidine. |
| Methotrexate | The excretion of Methotrexate can be decreased when combined with Guanidine. |
| Valaciclovir | The excretion of Valaciclovir can be decreased when combined with Guanidine. |
| Levocarnitine | The excretion of Levocarnitine can be decreased when combined with Guanidine. |
| Leucovorin | The excretion of Leucovorin can be decreased when combined with Guanidine. |
| Fluorescein | The excretion of Fluorescein can be decreased when combined with Guanidine. |
| Hydrocortisone | The excretion of Hydrocortisone can be decreased when combined with Guanidine. |
| Tetracycline | The excretion of Tetracycline can be decreased when combined with Guanidine. |
| Estradiol | The excretion of Estradiol can be decreased when combined with Guanidine. |
| Cefaclor | The excretion of Cefaclor can be decreased when combined with Guanidine. |
| Quinapril | The excretion of Quinapril can be decreased when combined with Guanidine. |
| Bumetanide | The excretion of Bumetanide can be decreased when combined with Guanidine. |
| Dinoprostone | The excretion of Dinoprostone can be decreased when combined with Guanidine. |
| Famotidine | The excretion of Famotidine can be decreased when combined with Guanidine. |
| Fexofenadine | The excretion of Fexofenadine can be decreased when combined with Guanidine. |
| Benzylpenicillin | The excretion of Benzylpenicillin can be decreased when combined with Guanidine. |
| Rosuvastatin | The excretion of Rosuvastatin can be decreased when combined with Guanidine. |
| Captopril | The excretion of Captopril can be decreased when combined with Guanidine. |
| Sitagliptin | The excretion of Sitagliptin can be decreased when combined with Guanidine. |
| Cefazolin | The excretion of Cefazolin can be decreased when combined with Guanidine. |
| Ceftizoxime | The excretion of Ceftizoxime can be decreased when combined with Guanidine. |
| Cefacetrile | The excretion of Cefacetrile can be decreased when combined with Guanidine. |
| Ceftibuten | The excretion of Ceftibuten can be decreased when combined with Guanidine. |
| Tazobactam | The excretion of Tazobactam can be decreased when combined with Guanidine. |
| Cyclic adenosine monophosphate | The excretion of Cyclic adenosine monophosphate can be decreased when combined with Guanidine. |
| Cholic Acid | The excretion of Cholic Acid can be decreased when combined with Guanidine. |
| Glutaric Acid | The excretion of Glutaric Acid can be decreased when combined with Guanidine. |
| Oxalic Acid | The excretion of Oxalic Acid can be decreased when combined with Guanidine. |
| Taurocholic acid | The excretion of Taurocholic acid can be decreased when combined with Guanidine. |
| Doripenem | The excretion of Doripenem can be decreased when combined with Guanidine. |
| Saxagliptin | The excretion of Saxagliptin can be decreased when combined with Guanidine. |
| Ellagic acid | The excretion of Ellagic acid can be decreased when combined with Guanidine. |
| Cefaloridine | The excretion of Cefaloridine can be decreased when combined with Guanidine. |
| Avibactam | The excretion of Avibactam can be decreased when combined with Guanidine. |
| Eluxadoline | The excretion of Eluxadoline can be decreased when combined with Guanidine. |
| Silibinin | The excretion of Silibinin can be decreased when combined with Guanidine. |
| Tenofovir alafenamide | The excretion of Tenofovir alafenamide can be decreased when combined with Guanidine. |
| Tenofovir | The excretion of Tenofovir can be decreased when combined with Guanidine. |
| Hydrochlorothiazide | The excretion of Hydrochlorothiazide can be decreased when combined with Guanidine. |
| Dexamethasone | The excretion of Dexamethasone can be decreased when combined with Guanidine. |
| Cephalexin | The excretion of Cephalexin can be decreased when combined with Guanidine. |
| Acyclovir | The excretion of Acyclovir can be decreased when combined with Guanidine. |
| Relebactam | The excretion of Relebactam can be decreased when combined with Guanidine. |
| Cimetidine | The excretion of Cimetidine can be decreased when combined with Guanidine. |
| Oxytetracycline | The excretion of Oxytetracycline can be decreased when combined with Guanidine. |
| Polythiazide | The excretion of Polythiazide can be decreased when combined with Guanidine. |
| Prednisolone phosphate | The excretion of Prednisolone phosphate can be decreased when combined with Guanidine. |
| Dexamethasone acetate | The excretion of Dexamethasone acetate can be decreased when combined with Guanidine. |
| Tipiracil | The excretion of Tipiracil can be decreased when combined with Guanidine. |
| Varenicline | The excretion of Varenicline can be decreased when combined with Guanidine. |
| Prazosin | The serum concentration of Prazosin can be increased when it is combined with Guanidine. |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Guanidine. |
| Choline salicylate | The serum concentration of Choline salicylate can be increased when it is combined with Guanidine. |
| Choline | The serum concentration of Choline can be increased when it is combined with Guanidine. |
| Metformin | The serum concentration of Metformin can be increased when it is combined with Guanidine. |
| Norepinephrine | The serum concentration of Norepinephrine can be increased when it is combined with Guanidine. |
| Solriamfetol | The serum concentration of Solriamfetol can be increased when it is combined with Guanidine. |
| Reserpine | The serum concentration of Reserpine can be increased when it is combined with Guanidine. |
| Pramipexole | The serum concentration of Pramipexole can be increased when it is combined with Guanidine. |
| Epinephrine | The serum concentration of Epinephrine can be increased when it is combined with Guanidine. |
| Lamivudine | The serum concentration of Lamivudine can be increased when it is combined with Guanidine. |
| Amantadine | The serum concentration of Amantadine can be increased when it is combined with Guanidine. |
| Dopamine | The serum concentration of Dopamine can be increased when it is combined with Guanidine. |
| Memantine | The serum concentration of Memantine can be increased when it is combined with Guanidine. |
| Histamine | The serum concentration of Histamine can be increased when it is combined with Guanidine. |
| Agmatine | The serum concentration of Agmatine can be increased when it is combined with Guanidine. |
| Nafamostat | The serum concentration of Nafamostat can be increased when it is combined with Guanidine. |
| Pemetrexed | Guanidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level. |
| Mercaptopurine | The excretion of Mercaptopurine can be decreased when combined with Guanidine. |
| Valproic acid | The excretion of Valproic acid can be decreased when combined with Guanidine. |
| Emtricitabine | The excretion of Emtricitabine can be decreased when combined with Guanidine. |
| Ganciclovir | The excretion of Ganciclovir can be decreased when combined with Guanidine. |
| Levofloxacin | The excretion of Levofloxacin can be decreased when combined with Guanidine. |
| Nadolol | The excretion of Nadolol can be decreased when combined with Guanidine. |
| Cefradine | The excretion of Cefradine can be decreased when combined with Guanidine. |
| Estrone sulfate | The excretion of Estrone sulfate can be decreased when combined with Guanidine. |
| N-methylnicotinamide | The excretion of N-methylnicotinamide can be decreased when combined with Guanidine. |
| Procainamide | The excretion of Procainamide can be decreased when combined with Guanidine. |
| Topotecan | The excretion of Topotecan can be decreased when combined with Guanidine. |
| Abemaciclib | The excretion of Abemaciclib can be decreased when combined with Guanidine. |
| Baricitinib | The serum concentration of Baricitinib can be increased when it is combined with Guanidine. |
| Pyrimethamine | The excretion of Guanidine can be decreased when combined with Pyrimethamine. |
| Ciprofloxacin | The excretion of Guanidine can be decreased when combined with Ciprofloxacin. |
| Flecainide | The excretion of Flecainide can be decreased when combined with Guanidine. |
| Lofexidine | The excretion of Guanidine can be decreased when combined with Lofexidine. |
| Tafenoquine | The excretion of Guanidine can be decreased when combined with Tafenoquine. |
| Tucatinib | The excretion of Guanidine can be decreased when combined with Tucatinib. |