Peringatan Keamanan

LD50 information
Oral LD50 of cefdinir in the rat is >2000 mg/kg.L7336

There are limited data regarding cefdinir overdose in the literature. In studies of rodents, one 5600-mg/kg dose administered orally did not lead to adverse effects. Signs of toxicity and overdose caused by other beta-lactam antibiotics included nausea, vomiting, diarrhea, abdominal pain, and seizures.L7339

Cefdinir

DB00535

small molecule approved

Deskripsi

Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of the cephalosporin class. It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin. Cefdinir was approved by the FDA in 1997 to treat a variety of mild to moderate infections and was initially marketed by Abbvie.A180739 Because of its chemical structure, it is effective against organisms that are resistant to first-line cephalosporin therapy due to the production of beta-lactamase enzymes.A180724,A180727

Struktur Molekul 2D

Berat 395.414
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The average plasma elimination half-life is about 1.7 hours in adults.[L7330] In children and healthy infants, plasma elimination half-life ranges from 1.2–1.5 hours.[A180724]
Volume Distribusi The average volume of distribution of cefdinir in adults is about 0.35 L/kg and 0.67 L/kg in children.[L7330,L7354] Another resource estimates the volume of distribution in adults at 1.56–2.09 L/kg.[A180724] Cefdinir is found to be distributed in various tissues at clinically effective concentrations. It may be found in the epithelial lining fluid, bronchial mucosa, tonsils, sinuses, skin blister fluid, as well as the middle ear fluid.[A180724] Third-generation cephalosporins such as cefdinir cross the blood-brain barrier and are found in high concentrations in the cerebrospinal fluid, unlike their first and second generation counterparts.[A180772] The wide tissue distribution of cefdinir allows it to treat a variety of infections throughout the body.
Klirens (Clearance) The renal clearance in healthy adults in a pharmacokinetic study was 2.0 (± 1.0) mL/min/kg and the clearance in patients with renal failure was lower, decreasing in proportion to the degree of renal impairment.[L7354] Dose adjustment is required in patients with renal impairment.[L7330]

Absorpsi

Maximal plasma cefdinir concentration can be attained between 2-4 hours after an ingested dose.L7330 The bioavailability of cefdinir depends on the formulation used. The estimated bioavailability of cefdinir in the capsule form is approximately 16%-21%, depending on the dose. Absolute bioavailability after the administration of a suspension of cefdinir is 25%.A180724. The Cmax of cefdinir is 1.60 ?g/mL after a 300 mg dose with an AUC of 7.05. Cmax is 2.87 ?g/mL after a 600 mg dose with an AUC of 11.L7330 A meal high in fat can reduce the absorption of cefdinir by up to 15%, however, this is not a cause for clinically significant changes, therefore cefdinir may be taken with or without food.L7330 When given with aluminum or magnesium-containing antacids or iron, cefdinir absorption may decrease. It is recommended to allow 2 hours between cefdinir administration and the administration of these agents.A180724

Metabolisme

This drug is not significantly metabolized and its pharmacological actions are mainly attributed to the parent drug.A180724,L7330

Rute Eliminasi

This drug is mainly excreted by the kidneys. Dose adjustments may be required for patients with renal impairment or patients on dialysis.L7330 Approximately 18.4% of a 300 mg dose of cefdinir was found unchanged in the urine after a 300 mg dose was administered during a pharmacokinetic study of 21 individuals.L7354 A large proportion of the administered dose is excreted in the feces, although the majority is found in the urine.A180772

Interaksi Makanan

2 Data
  • 1. Avoid multivalent ions. Do not take aluminum, magnesium, or iron containing products up to 2 hours before or after this medication.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

936 Data
Aspartame The excretion of Cefdinir can be decreased when combined with Aspartame.
Pravastatin The excretion of Cefdinir can be decreased when combined with Pravastatin.
Pantoprazole The excretion of Cefdinir can be decreased when combined with Pantoprazole.
Cefotiam The excretion of Cefdinir can be decreased when combined with Cefotiam.
Liothyronine The excretion of Cefdinir can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Cefdinir can be decreased when combined with Conjugated estrogens.
Valproic acid The excretion of Cefdinir can be decreased when combined with Valproic acid.
Indomethacin The excretion of Cefdinir can be decreased when combined with Indomethacin.
Aminohippuric acid The excretion of Cefdinir can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Cefdinir can be decreased when combined with Lansoprazole.
Cefalotin The excretion of Cefdinir can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Cefdinir can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Cefdinir can be decreased when combined with Cefotaxime.
Zidovudine The excretion of Cefdinir can be decreased when combined with Zidovudine.
Cimetidine The excretion of Cefdinir can be decreased when combined with Cimetidine.
Guanidine The excretion of Cefdinir can be decreased when combined with Guanidine.
Piroxicam The excretion of Cefdinir can be decreased when combined with Piroxicam.
Methotrexate The excretion of Cefdinir can be decreased when combined with Methotrexate.
Cephalexin The excretion of Cefdinir can be decreased when combined with Cephalexin.
Enalapril The excretion of Cefdinir can be decreased when combined with Enalapril.
Diclofenac The excretion of Cefdinir can be decreased when combined with Diclofenac.
Oxytetracycline The excretion of Cefdinir can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Cefdinir can be decreased when combined with Leucovorin.
Esomeprazole The excretion of Cefdinir can be decreased when combined with Esomeprazole.
Tetracycline The excretion of Cefdinir can be decreased when combined with Tetracycline.
Acyclovir The excretion of Cefdinir can be decreased when combined with Acyclovir.
Phenylbutazone The excretion of Cefdinir can be decreased when combined with Phenylbutazone.
Cefaclor The excretion of Cefdinir can be decreased when combined with Cefaclor.
Bumetanide The excretion of Cefdinir can be decreased when combined with Bumetanide.
Dinoprostone The excretion of Cefdinir can be decreased when combined with Dinoprostone.
Famotidine The excretion of Cefdinir can be decreased when combined with Famotidine.
Salicylic acid The excretion of Cefdinir can be decreased when combined with Salicylic acid.
Acetylsalicylic acid The excretion of Cefdinir can be decreased when combined with Acetylsalicylic acid.
Ganciclovir The excretion of Cefdinir can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Cefdinir can be decreased when combined with Ketoprofen.
Minocycline The excretion of Cefdinir can be decreased when combined with Minocycline.
Mercaptopurine The excretion of Cefdinir can be decreased when combined with Mercaptopurine.
Ibuprofen The excretion of Cefdinir can be decreased when combined with Ibuprofen.
Novobiocin The excretion of Cefdinir can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Cefdinir can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Cefdinir can be decreased when combined with Melatonin.
Ouabain The excretion of Cefdinir can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Cefdinir can be decreased when combined with Rosuvastatin.
Cefadroxil The excretion of Cefdinir can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Cefdinir can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Cefdinir can be decreased when combined with Cefamandole.
Cefazolin The excretion of Cefdinir can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Cefdinir can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Cefdinir can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Cefdinir can be decreased when combined with Cefacetrile.
Ceftibuten The excretion of Cefdinir can be decreased when combined with Ceftibuten.
Liotrix The excretion of Cefdinir can be decreased when combined with Liotrix.
Cilastatin The excretion of Cefdinir can be decreased when combined with Cilastatin.
Tazobactam The excretion of Cefdinir can be decreased when combined with Tazobactam.
trans-2-hydroxycinnamic acid The excretion of Cefdinir can be decreased when combined with trans-2-hydroxycinnamic acid.
Topiroxostat The excretion of Cefdinir can be decreased when combined with Topiroxostat.
Cholic Acid The excretion of Cefdinir can be decreased when combined with Cholic Acid.
Glutaric Acid The excretion of Cefdinir can be decreased when combined with Glutaric Acid.
Benzoic acid The excretion of Cefdinir can be decreased when combined with Benzoic acid.
Taurocholic acid The excretion of Cefdinir can be decreased when combined with Taurocholic acid.
Caprylic acid The excretion of Cefdinir can be decreased when combined with Caprylic acid.
Ataluren The excretion of Cefdinir can be decreased when combined with Ataluren.
Teriflunomide The excretion of Cefdinir can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Cefdinir can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Cefdinir can be decreased when combined with Dolutegravir.
Cefaloridine The excretion of Cefdinir can be decreased when combined with Cefaloridine.
Lenvatinib The excretion of Cefdinir can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Cefdinir can be decreased when combined with Cabotegravir.
Baricitinib Cefdinir may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Apalutamide The excretion of Cefdinir can be decreased when combined with Apalutamide.
Pradigastat The excretion of Cefdinir can be decreased when combined with Pradigastat.
Enasidenib The excretion of Cefdinir can be decreased when combined with Enasidenib.
Gemfibrozil The excretion of Cefdinir can be decreased when combined with Gemfibrozil.
Dronedarone The excretion of Cefdinir can be decreased when combined with Dronedarone.
Favipiravir The excretion of Cefdinir can be decreased when combined with Favipiravir.
Tafamidis The excretion of Cefdinir can be decreased when combined with Tafamidis.
Linezolid The excretion of Cefdinir can be decreased when combined with Linezolid.
Iron Dextran Iron Dextran can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Iron can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prussian blue Prussian blue can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose Iron sucrose can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric pyrophosphate Ferric pyrophosphate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric ammonium citrate Ferric ammonium citrate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferumoxsil Ferumoxsil can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferumoxides Ferumoxides can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate Ferric sulfate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous bisglycinate Ferrous bisglycinate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gleptoferron Gleptoferron can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxide Ferric oxide can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Perflubutane Perflubutane can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous sulfate anhydrous Ferrous sulfate anhydrous can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium feredetate Sodium feredetate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric hydroxide Ferric hydroxide can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation Ferric cation can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous gluconate Ferrous gluconate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous succinate Ferrous succinate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous fumarate Ferrous fumarate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetraferric tricitrate decahydrate Tetraferric tricitrate decahydrate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxyhydroxide Ferric oxyhydroxide can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric maltol Ferric maltol can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Target Protein

Penicillin-binding protein 2 penA
PBP3 pbp3
Myeloperoxidase MPO
Peptidoglycan transpeptidase

Referensi & Sumber

Synthesis reference: Gwan Sun Lee, Young Kil Chang, Jong Pil Chun, Joon Hyung Koh, "Process for preparation of cefdinir." U.S. Patent US6093814, issued December, 1995.
Artikel (PubMed)
  • PMID: 11300142
    Kimura Y, Kawamura M, Owada M, Fujiwara T, Maesawa C, Hiramori K: Successful steroid therapy for cefdinir-induced acute tubulointerstitial nephritis with progressive renal failure. Intern Med. 2001 Feb;40(2):114-7. doi: 10.2169/internalmedicine.40.114.
  • PMID: 15212560
    Perry CM, Scott LJ: Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections. Drugs. 2004;64(13):1433-64. doi: 10.2165/00003495-200464130-00004.
  • PMID: 11144395
    Guay DR: Pharmacodynamics and pharmacokinetics of cefdinir, an oral extended spectrum cephalosporin. Pediatr Infect Dis J. 2000 Dec;19(12 Suppl):S141-6.
  • PMID: 15182160
    Paris MM, Devcich KJ: Overview of cefdinir: pharmacokinetics, safety, and efficacy in the treatment of uncomplicated skin and skin structure infections. Cutis. 2004 May;73(5 Suppl):14-8.
  • PMID: 18752027
    Chen J, Ahmad J: Cefdinir-induced hepatotoxicity: potential hazards of inappropriate antibiotic use. J Gen Intern Med. 2008 Nov;23(11):1914-6. doi: 10.1007/s11606-008-0758-y. Epub 2008 Aug 28.
  • PMID: 15620832
    Sader HS, Biedenbach DJ, Streit JM, Jones RN: Cefdinir activity against contemporary North American isolates from community-acquired urinary tract infections. Int J Antimicrob Agents. 2005 Jan;25(1):89-92. doi: 10.1016/j.ijantimicag.2004.07.006.
  • PMID: 17540669
    Ochiai S, Sekiguchi S, Hayashi A, Shimadzu M, Ishiko H, Matsushima-Nishiwaki R, Kozawa O, Yasuda M, Deguchi T: Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae. J Antimicrob Chemother. 2007 Jul;60(1):54-60. Epub 2007 May 31.
  • PMID: 28630190
    Ferrer-Gonzalez E, Kaul M, Parhi AK, LaVoie EJ, Pilch DS: beta-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: AAC.00863-17. doi: 10.1128/AAC.00863-17. Print 2017 Sep.
Menampilkan 8 dari 13 artikel.

Contoh Produk & Brand

Produk: 188 • International brands: 18
Produk
  • Cefdinir
    Powder, for suspension • 125 mg/5mL • Oral • US • Generic • Approved
  • Cefdinir
    Powder, for suspension • 250 mg/5mL • Oral • US • Generic • Approved
  • Cefdinir
    Capsule • 300 mg/1 • Oral • US • Generic • Approved
  • Cefdinir
    Powder, for suspension • 250 mg/5mL • Oral • US • Generic • Approved
  • Cefdinir
    Capsule • 300 mg/1 • Oral • US • Generic • Approved
  • Cefdinir
    Capsule • 300 mg/1 • Oral • US • Generic • Approved
  • Cefdinir
    Capsule • 300 mg/1 • Oral • US • Generic • Approved
  • Cefdinir
    Capsule • 300 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 188 produk.
International Brands
  • Cednir — Abbott
  • Cefdiel — Ranbaxy
  • Cefzon — Astellas
  • Duocef — Ranbaxy
  • Efdinir — Incepta
  • Idinir — Invision
  • Kefnir — Glenmark
  • Nirocef — Sel-J
  • Oceph — Zuventus
  • Omicef — Sel-J

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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