Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and Cytochrome P450 2D6 are known to metabolize mephenytoin. Mephenytoin is a hydantoin-derivative anticonvulsant used to control various partial seizures. Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias compared to other anticonvulsants.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
Patients with this genotype have reduced metabolism of mephenytoin.
Patients with this genotype have reduced metabolism of mephenytoin.
Patients with this genotype have reduced metabolism of mephenytoin.
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Mephenytoin. |
| Deferasirox | The serum concentration of Mephenytoin can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Mephenytoin can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Mephenytoin can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Mephenytoin can be decreased when it is combined with Teriflunomide. |
| Buprenorphine | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Hydrocodone | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Magnesium sulfate | The therapeutic efficacy of Mephenytoin can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Mephenytoin may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Mirtazapine | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Orphenadrine | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Pramipexole | Mephenytoin may increase the sedative activities of Pramipexole. |
| Ropinirole | Mephenytoin may increase the sedative activities of Ropinirole. |
| Rotigotine | Mephenytoin may increase the sedative activities of Rotigotine. |
| Sodium oxybate | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Thalidomide | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Mefloquine | The therapeutic efficacy of Mephenytoin can be decreased when used in combination with Mefloquine. |
| Mianserin | The therapeutic efficacy of Mephenytoin can be decreased when used in combination with Mianserin. |
| Orlistat | Orlistat can cause a decrease in the absorption of Mephenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Metyrapone | The serum concentration of Metyrapone can be decreased when it is combined with Mephenytoin. |
| Rufinamide | The serum concentration of Mephenytoin can be increased when it is combined with Rufinamide. |
| Topotecan | Mephenytoin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Mephenytoin. |
| Mifepristone | The serum concentration of Mephenytoin can be increased when it is combined with Mifepristone. |
| Tetracosactide | The risk or severity of liver damage can be increased when Tetracosactide is combined with Mephenytoin. |
| Mirabegron | The serum concentration of Mephenytoin can be increased when it is combined with Mirabegron. |
| Eslicarbazepine acetate | The serum concentration of Eslicarbazepine acetate can be decreased when it is combined with Mephenytoin. |
| Eslicarbazepine | The serum concentration of Eslicarbazepine can be decreased when it is combined with Mephenytoin. |
| Abiraterone | The serum concentration of Mephenytoin can be increased when it is combined with Abiraterone. |
| Cyproterone acetate | The metabolism of Mephenytoin can be increased when combined with Cyproterone acetate. |
| Ethanol | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin. |
| Sibutramine | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Sibutramine. |
| Zimelidine | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Zimelidine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Milnacipran. |
| Seproxetine | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Indalpine. |
| Alaproclate | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Alaproclate. |
| Trazodone | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Trazodone. |
| Sertraline | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Sertraline. |
| Nefazodone | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Nefazodone. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Dapoxetine. |
| Desvenlafaxine | The serum concentration of Mephenytoin can be increased when it is combined with Desvenlafaxine. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Mephenytoin. |
| Propiomazine | The risk or severity of CNS depression can be increased when Mephenytoin is combined with Propiomazine. |
| Pizotifen | The risk or severity of CNS depression can be increased when Mephenytoin is combined with Pizotifen. |
| Trospium | The metabolism of Mephenytoin can be decreased when combined with Trospium. |
| Benzatropine | The metabolism of Mephenytoin can be decreased when combined with Benzatropine. |
| Olanzapine | The risk or severity of CNS depression can be increased when Olanzapine is combined with Mephenytoin. |
| Promazine | The risk or severity of CNS depression can be increased when Promazine is combined with Mephenytoin. |
| Biperiden | The metabolism of Mephenytoin can be decreased when combined with Biperiden. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Mephenytoin is combined with Cocaine. |
| Maprotiline | The risk or severity of CNS depression can be increased when Mephenytoin is combined with Maprotiline. |
| Tolterodine | The metabolism of Tolterodine can be decreased when combined with Mephenytoin. |
| Oxybutynin | The metabolism of Mephenytoin can be decreased when combined with Oxybutynin. |
| Promethazine | The risk or severity of CNS depression can be increased when Mephenytoin is combined with Promethazine. |
| Diphenhydramine | The risk or severity of methemoglobinemia can be increased when Mephenytoin is combined with Diphenhydramine. |
| Doxepin | The risk or severity of CNS depression can be increased when Mephenytoin is combined with Doxepin. |
| Quetiapine | The risk or severity of CNS depression can be increased when Mephenytoin is combined with Quetiapine. |
| Aripiprazole | The risk or severity of CNS depression can be increased when Mephenytoin is combined with Aripiprazole. |
| Tiotropium | The metabolism of Tiotropium can be decreased when combined with Mephenytoin. |
| Solifenacin | The metabolism of Solifenacin can be decreased when combined with Mephenytoin. |
| Fesoterodine | The metabolism of Fesoterodine can be decreased when combined with Mephenytoin. |
| Umeclidinium | The metabolism of Umeclidinium can be decreased when combined with Mephenytoin. |
| Revefenacin | The metabolism of Revefenacin can be decreased when combined with Mephenytoin. |
| Zopiclone | The risk or severity of adverse effects can be increased when Mephenytoin is combined with Zopiclone. |
| Rifampin | The metabolism of Mephenytoin can be increased when combined with Rifampicin. |
| Primidone | The metabolism of Mephenytoin can be increased when combined with Primidone. |
| Albendazole | The metabolism of Mephenytoin can be increased when combined with Albendazole. |
| Caffeine | The metabolism of Mephenytoin can be decreased when combined with Caffeine. |
| Moxifloxacin | The metabolism of Mephenytoin can be decreased when combined with Moxifloxacin. |
| Lidocaine | The risk or severity of methemoglobinemia can be increased when Mephenytoin is combined with Lidocaine. |
| Mexiletine | The metabolism of Mephenytoin can be decreased when combined with Mexiletine. |
| Gatifloxacin | The metabolism of Mephenytoin can be decreased when combined with Gatifloxacin. |
| Simeprevir | The metabolism of Mephenytoin can be decreased when combined with Simeprevir. |
| Lobeglitazone | The metabolism of Mephenytoin can be decreased when combined with Lobeglitazone. |
| Pazufloxacin | The metabolism of Mephenytoin can be decreased when combined with Pazufloxacin. |
| Osilodrostat | The metabolism of Mephenytoin can be decreased when combined with Osilodrostat. |
| Imipramine | The metabolism of Mephenytoin can be decreased when combined with Imipramine. |
| Desipramine | The metabolism of Mephenytoin can be decreased when combined with Desipramine. |
| Dosulepin | The metabolism of Mephenytoin can be decreased when combined with Dosulepin. |
| Cyclosporine | The metabolism of Mephenytoin can be decreased when combined with Cyclosporine. |
| Cimetidine | The metabolism of Mephenytoin can be decreased when combined with Cimetidine. |
| Ketoconazole | The metabolism of Mephenytoin can be decreased when combined with Ketoconazole. |
| Sulfaphenazole | The metabolism of Mephenytoin can be decreased when combined with Sulfaphenazole. |
| Manidipine | The metabolism of Mephenytoin can be decreased when combined with Manidipine. |
| Cholecalciferol | The metabolism of Mephenytoin can be decreased when combined with Cholecalciferol. |