Peringatan Keamanan

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Foscarnet

DB00529

small molecule approved

Deskripsi

An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.

Struktur Molekul 2D

Berat 126.0053
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3.3-6.8 hours
Volume Distribusi -
Klirens (Clearance) * 2.13 +/- 0.71 mL/min/kg [patients had normal renal function (CrCl > 80 mL/min] * 68 +/- 8 mL/min/kg [CrCl was 50-80 mL/min] * 34 +/- 9 mL/min/kg [CrCl was 25-49 mL/min] * 20 +/- 4 mL/min/kg [CrCl was 10 - 24 mL/min]

Absorpsi

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Metabolisme

Not metabolized.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1022 Data
Cyclosporine Foscarnet may increase the nephrotoxic activities of Cyclosporine.
Torasemide Torasemide may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Piretanide Piretanide may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Azosemide Azosemide may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Tripamide Tripamide may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Foscarnet.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Foscarnet.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Foscarnet.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Foscarnet.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Foscarnet.
Pamidronic acid The risk or severity of nephrotoxicity can be increased when Pamidronic acid is combined with Foscarnet.
Tenofovir disoproxil The risk or severity of nephrotoxicity can be increased when Tenofovir disoproxil is combined with Foscarnet.
Capreomycin The risk or severity of nephrotoxicity can be increased when Capreomycin is combined with Foscarnet.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Foscarnet.
Cidofovir The risk or severity of nephrotoxicity can be increased when Cidofovir is combined with Foscarnet.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Foscarnet.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Foscarnet.
Ceftazidime The risk or severity of nephrotoxicity can be increased when Ceftazidime is combined with Foscarnet.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Foscarnet.
Framycetin The risk or severity of nephrotoxicity can be increased when Framycetin is combined with Foscarnet.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Foscarnet.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Foscarnet.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Foscarnet.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Foscarnet.
Amikacin The risk or severity of nephrotoxicity can be increased when Amikacin is combined with Foscarnet.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Foscarnet.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Foscarnet.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Foscarnet.
Vancomycin The risk or severity of nephrotoxicity can be increased when Vancomycin is combined with Foscarnet.
Cisplatin The risk or severity of nephrotoxicity can be increased when Cisplatin is combined with Foscarnet.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Foscarnet.
Piroxicam The risk or severity of nephrotoxicity can be increased when Piroxicam is combined with Foscarnet.
Methotrexate The risk or severity of nephrotoxicity can be increased when Methotrexate is combined with Foscarnet.
Cephalexin The risk or severity of nephrotoxicity can be increased when Cephalexin is combined with Foscarnet.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Foscarnet.
Valaciclovir The risk or severity of nephrotoxicity can be increased when Valaciclovir is combined with Foscarnet.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Foscarnet.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Foscarnet.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Foscarnet.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Foscarnet.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Foscarnet.
Tobramycin The risk or severity of nephrotoxicity can be increased when Tobramycin is combined with Foscarnet.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Foscarnet.
Furosemide Furosemide may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Flurbiprofen The risk or severity of nephrotoxicity can be increased when Flurbiprofen is combined with Foscarnet.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Foscarnet.
Etodolac The risk or severity of nephrotoxicity can be increased when Etodolac is combined with Foscarnet.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Foscarnet.
Acyclovir The risk or severity of nephrotoxicity can be increased when Acyclovir is combined with Foscarnet.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Foscarnet.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Foscarnet.
Gentamicin The risk or severity of nephrotoxicity can be increased when Gentamicin is combined with Foscarnet.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Foscarnet.
Meloxicam The risk or severity of nephrotoxicity can be increased when Meloxicam is combined with Foscarnet.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Foscarnet.
Cefaclor The risk or severity of nephrotoxicity can be increased when Cefaclor is combined with Foscarnet.
Diflunisal The risk or severity of nephrotoxicity can be increased when Diflunisal is combined with Foscarnet.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Foscarnet.
Bumetanide Bumetanide may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Etacrynic acid Etacrynic acid may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Foscarnet.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Foscarnet.
Meclofenamic acid The risk or severity of nephrotoxicity can be increased when Meclofenamic acid is combined with Foscarnet.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Foscarnet.
Netilmicin The risk or severity of nephrotoxicity can be increased when Netilmicin is combined with Foscarnet.
Carboplatin The risk or severity of nephrotoxicity can be increased when Carboplatin is combined with Foscarnet.
Oxaprozin The risk or severity of nephrotoxicity can be increased when Oxaprozin is combined with Foscarnet.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Foscarnet.
Ketoprofen The risk or severity of nephrotoxicity can be increased when Ketoprofen is combined with Foscarnet.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Foscarnet.
Ibuprofen The risk or severity of nephrotoxicity can be increased when Ibuprofen is combined with Foscarnet.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Foscarnet.
Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Foscarnet.
Streptomycin The risk or severity of nephrotoxicity can be increased when Streptomycin is combined with Foscarnet.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Foscarnet.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Foscarnet.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Foscarnet.
Cefadroxil The risk or severity of nephrotoxicity can be increased when Cefadroxil is combined with Foscarnet.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Foscarnet.
Kanamycin The risk or severity of nephrotoxicity can be increased when Kanamycin is combined with Foscarnet.
Ceftriaxone The risk or severity of nephrotoxicity can be increased when Ceftriaxone is combined with Foscarnet.
Olsalazine The risk or severity of nephrotoxicity can be increased when Olsalazine is combined with Foscarnet.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Lumiracoxib is combined with Foscarnet.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefamandole is combined with Foscarnet.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Foscarnet.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefonicid is combined with Foscarnet.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefoperazone is combined with Foscarnet.
Cefotetan The risk or severity of nephrotoxicity can be increased when Cefotetan is combined with Foscarnet.
Cefoxitin The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Foscarnet.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Ceftizoxime is combined with Foscarnet.
Cefradine The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Foscarnet.
Lithium cation The risk or severity of nephrotoxicity can be increased when Lithium cation is combined with Foscarnet.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Magnesium salicylate is combined with Foscarnet.
Salsalate The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Foscarnet.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Choline magnesium trisalicylate is combined with Foscarnet.
Cefepime The risk or severity of nephrotoxicity can be increased when Cefepime is combined with Foscarnet.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Cefacetrile is combined with Foscarnet.
Ceftibuten The risk or severity of nephrotoxicity can be increased when Ceftibuten is combined with Foscarnet.
Cefpodoxime The risk or severity of nephrotoxicity can be increased when Cefpodoxime is combined with Foscarnet.
Antrafenine The risk or severity of nephrotoxicity can be increased when Antrafenine is combined with Foscarnet.

Target Protein

DNA polymerase catalytic subunit
DNA polymerase catalytic subunit UL54

Referensi & Sumber

Synthesis reference: Charles E. McKenna, "Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid." U.S. Patent US5072032, issued February, 1953.

Contoh Produk & Brand

Produk: 12 • International brands: 1
Produk
  • Foscarnet
    Injection, solution • 24 mg/1mL • Intravenous • US • Generic • Approved
  • Foscarnet Sodium
    Injection, solution • 24 mg/1mL • Intravenous • US • Generic • Approved
  • Foscarnet Sodium
    Injection, solution • 24 mg/1mL • Intravenous • US • Generic • Approved
  • Foscarnet Sodium
    Injection, solution • 24 mg/1mL • Intravenous • US • Generic • Approved
  • Foscarnet Sodium
    Injection, solution • 24 mg/1mL • Intravenous • US • Generic • Approved
  • Foscarnet Sodium
    Injection, solution • 6000 mg/250mL • Intravenous • US • Generic • Approved
  • Foscarnet Sodium
    Injection • 24 mg/1mL • Intravenous • US • Generic • Approved
  • Foscarnet Sodium
    Injection, solution • 24 mg/1mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 12 produk.
International Brands
  • Triapten

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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