Lercanidipine

DB00528

small molecule approved investigational

Deskripsi

Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.

Struktur Molekul 2D

Berat 611.7272
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

4 Data
  • 1. Avoid alcohol. Alcohol may increase the vasodilatory effects of lercanidipine, which may lead to hypotension.
  • 2. Avoid grapefruit products. Grapefruit inhibits the metabolism of lercanidipine through CYP3A4, which causes increased serum levels of lercanidipine, and may increase the risk of hypotension.
  • 3. Exercise caution with St. John's Wort. Lercanidipine is metabolized by CYP3A4, and St. John's Wort is a CYP3A4 inducer.
  • 4. Take on an empty stomach. Taking lercanidipine after meals increases its bioavailability, therefore lercanidipine should be taken least 15 minutes before meals.

Interaksi Obat

1325 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Lercanidipine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Lercanidipine is combined with Levodopa.
Risperidone Lercanidipine may increase the hypotensive activities of Risperidone.
Ceritinib Lercanidipine may increase the bradycardic activities of Ceritinib.
Ivabradine Lercanidipine may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Lercanidipine.
Alfuzosin Alfuzosin may increase the hypotensive activities of Lercanidipine.
Amifostine Lercanidipine may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Lercanidipine.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Lercanidipine.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Lercanidipine.
Obinutuzumab Lercanidipine may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Lercanidipine.
Rituximab Lercanidipine may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Lercanidipine.
Isoetharine Isoetharine may decrease the antihypertensive activities of Lercanidipine.
Etomidate Etomidate may decrease the antihypertensive activities of Lercanidipine.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Lercanidipine.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Lercanidipine.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Lercanidipine.
Doxapram Doxapram may decrease the antihypertensive activities of Lercanidipine.
Metaraminol Metaraminol may decrease the antihypertensive activities of Lercanidipine.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Lercanidipine.
Methoxamine Methoxamine may decrease the antihypertensive activities of Lercanidipine.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Lercanidipine.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Lercanidipine.
Dobutamine Dobutamine may decrease the antihypertensive activities of Lercanidipine.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Lercanidipine.
Ritodrine Ritodrine may decrease the antihypertensive activities of Lercanidipine.
Terbutaline Terbutaline may decrease the antihypertensive activities of Lercanidipine.
Bitolterol Bitolterol may decrease the antihypertensive activities of Lercanidipine.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Lercanidipine.
Naratriptan Naratriptan may decrease the antihypertensive activities of Lercanidipine.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Lercanidipine.
Dopamine Dopamine may decrease the antihypertensive activities of Lercanidipine.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Lercanidipine.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Lercanidipine.
Arbutamine Arbutamine may decrease the antihypertensive activities of Lercanidipine.
Fenoterol Fenoterol may decrease the antihypertensive activities of Lercanidipine.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Lercanidipine.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Lercanidipine.
Ephedrine Ephedrine may decrease the antihypertensive activities of Lercanidipine.
Mephentermine Mephentermine may decrease the antihypertensive activities of Lercanidipine.
Procaterol Procaterol may decrease the antihypertensive activities of Lercanidipine.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Lercanidipine.
Bambuterol Bambuterol may decrease the antihypertensive activities of Lercanidipine.
MMDA MMDA may decrease the antihypertensive activities of Lercanidipine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Lercanidipine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Lercanidipine.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Lercanidipine.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Lercanidipine.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Lercanidipine.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Lercanidipine.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Lercanidipine.
Amineptine Amineptine may decrease the antihypertensive activities of Lercanidipine.
Amibegron Amibegron may decrease the antihypertensive activities of Lercanidipine.
Naluzotan Naluzotan may decrease the antihypertensive activities of Lercanidipine.
Solabegron Solabegron may decrease the antihypertensive activities of Lercanidipine.
Droxidopa Droxidopa may decrease the antihypertensive activities of Lercanidipine.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Lercanidipine.
Isometheptene Isometheptene may decrease the antihypertensive activities of Lercanidipine.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Lercanidipine.
Naphazoline Naphazoline may decrease the antihypertensive activities of Lercanidipine.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Lercanidipine.
Cinitapride Cinitapride may decrease the antihypertensive activities of Lercanidipine.
Tyramine Tyramine may decrease the antihypertensive activities of Lercanidipine.
Adrafinil Adrafinil may decrease the antihypertensive activities of Lercanidipine.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Lercanidipine.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Lercanidipine.
Etilefrine Etilefrine may decrease the antihypertensive activities of Lercanidipine.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Lercanidipine.
Butriptyline Butriptyline may decrease the antihypertensive activities of Lercanidipine.
Olodaterol Olodaterol may decrease the antihypertensive activities of Lercanidipine.
Cirazoline Cirazoline may decrease the antihypertensive activities of Lercanidipine.
Synephrine Synephrine may decrease the antihypertensive activities of Lercanidipine.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Lercanidipine.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Lercanidipine.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Lercanidipine.
Racepinephrine Racepinephrine may decrease the antihypertensive activities of Lercanidipine.
DL-Methylephedrine DL-Methylephedrine may decrease the antihypertensive activities of Lercanidipine.
Amitraz Amitraz may decrease the antihypertensive activities of Lercanidipine.
Medetomidine Medetomidine may decrease the antihypertensive activities of Lercanidipine.
Xylazine Xylazine may decrease the antihypertensive activities of Lercanidipine.
Atipamezole Atipamezole may decrease the antihypertensive activities of Lercanidipine.
Ractopamine Ractopamine may decrease the antihypertensive activities of Lercanidipine.
Romifidine Romifidine may decrease the antihypertensive activities of Lercanidipine.
Detomidine Detomidine may decrease the antihypertensive activities of Lercanidipine.
Etafedrine Etafedrine may decrease the antihypertensive activities of Lercanidipine.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Lercanidipine.
PF-00610355 PF-00610355 may decrease the antihypertensive activities of Lercanidipine.
Ritobegron Ritobegron may decrease the antihypertensive activities of Lercanidipine.
Abediterol Abediterol may decrease the antihypertensive activities of Lercanidipine.
Tulobuterol Tulobuterol may decrease the antihypertensive activities of Lercanidipine.
Dopexamine Dopexamine may decrease the antihypertensive activities of Lercanidipine.
Piclozotan Piclozotan may decrease the antihypertensive activities of Lercanidipine.
Idazoxan Idazoxan may decrease the antihypertensive activities of Lercanidipine.
Higenamine Higenamine may decrease the antihypertensive activities of Lercanidipine.
Reproterol Reproterol may decrease the antihypertensive activities of Lercanidipine.
Theodrenaline Theodrenaline may decrease the antihypertensive activities of Lercanidipine.
Tramazoline Tramazoline may decrease the antihypertensive activities of Lercanidipine.

Target Protein

Voltage-dependent calcium channel gamma-1 subunit CACNG1
Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1

Referensi & Sumber

Synthesis reference: Bandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Rapolu Raji Reddy, Dasari Muralidhara Reddy, Dandamudi Satish Kumar, " NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE." U.S. Patent US20090227800, issued September 10, 2009.
Artikel (PubMed)
  • PMID: 16679299
    Lin TH, Voon WC, Yen HW, Huang CH, Su HM, Lai WT, Sheu SH: Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters. Kaohsiung J Med Sci. 2006 Apr;22(4):177-83.
  • PMID: 16424795
    Martinez ML, Lopes LF, Coelho EB, Nobre F, Rocha JB, Gerlach RF, Tanus-Santos JE: Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension. J Cardiovasc Pharmacol. 2006 Jan;47(1):117-22.
  • PMID: 16331117
    Agrawal R, Marx A, Haller H: Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension. J Hypertens. 2006 Jan;24(1):185-92.

Contoh Produk & Brand

Produk: 0 • International brands: 11
International Brands
  • Cardiovasc
  • Carmen
  • Corifeo
  • Lercanil
  • Lercaton
  • Lerzam
  • Renovia
  • Vasodip
  • Zandip
  • Zanicor

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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