Peringatan Keamanan

Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.

Metolazone

DB00524

small molecule approved

Deskripsi

A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.

Struktur Molekul 2D

Berat 365.835
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 14 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Peak blood levels are obtained within 2 to 4 hours of oral administration. The rate and extent of absorption are formulation dependent.

Metabolisme

Not substantially metabolized. 70-95% is excreted unchanged in urine via glomerular filtration and active tubular secretion. Undergoes enterohepatic recycling.

Rute Eliminasi

Most of the drug is excreted in the unconverted form in the urine.

Interaksi Makanan

1 Data
  • 1. Take with food. Food reduces irritation.

Interaksi Obat

1551 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Metolazone is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Metolazone is combined with Levodopa.
Risperidone Metolazone may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Metolazone.
Amifostine Metolazone may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Metolazone.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Metolazone.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Metolazone.
Obinutuzumab Metolazone may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Metolazone.
Rituximab Metolazone may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Metolazone.
Midodrine Midodrine may decrease the antihypertensive activities of Metolazone.
Eletriptan Eletriptan may decrease the antihypertensive activities of Metolazone.
Methysergide Methysergide may decrease the antihypertensive activities of Metolazone.
Cabergoline Cabergoline may decrease the antihypertensive activities of Metolazone.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Metolazone.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Metolazone.
Protriptyline Protriptyline may decrease the antihypertensive activities of Metolazone.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Metolazone.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Metolazone.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Metolazone.
Droperidol Droperidol may decrease the antihypertensive activities of Metolazone.
Doxapram Doxapram may decrease the antihypertensive activities of Metolazone.
Lisuride Lisuride may decrease the antihypertensive activities of Metolazone.
Metaraminol Metaraminol may decrease the antihypertensive activities of Metolazone.
Ergotamine Ergotamine may decrease the antihypertensive activities of Metolazone.
Nicergoline Nicergoline may decrease the antihypertensive activities of Metolazone.
Methoxamine Methoxamine may decrease the antihypertensive activities of Metolazone.
Trimipramine Trimipramine may decrease the antihypertensive activities of Metolazone.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Metolazone.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Metolazone.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Metolazone.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Metolazone.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Metolazone.
Naratriptan Naratriptan may decrease the antihypertensive activities of Metolazone.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Metolazone.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Metolazone.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Metolazone.
Dutasteride Dutasteride may decrease the antihypertensive activities of Metolazone.
Propafenone Propafenone may decrease the antihypertensive activities of Metolazone.
Pergolide Pergolide may decrease the antihypertensive activities of Metolazone.
Finasteride Finasteride may decrease the antihypertensive activities of Metolazone.
Ergometrine Ergometrine may decrease the antihypertensive activities of Metolazone.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Metolazone.
Mephentermine Mephentermine may decrease the antihypertensive activities of Metolazone.
Yohimbine Yohimbine may decrease the antihypertensive activities of Metolazone.
MMDA MMDA may decrease the antihypertensive activities of Metolazone.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Metolazone.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Metolazone.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Metolazone.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Metolazone.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Metolazone.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Metolazone.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Metolazone.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Metolazone.
Periciazine Periciazine may decrease the antihypertensive activities of Metolazone.
Acepromazine Acepromazine may decrease the antihypertensive activities of Metolazone.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Metolazone.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Metolazone.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Metolazone.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Metolazone.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Metolazone.
Amineptine Amineptine may decrease the antihypertensive activities of Metolazone.
Dronedarone Dronedarone may decrease the antihypertensive activities of Metolazone.
Flibanserin Flibanserin may decrease the antihypertensive activities of Metolazone.
Iloperidone Iloperidone may decrease the antihypertensive activities of Metolazone.
Amibegron Amibegron may decrease the antihypertensive activities of Metolazone.
Naluzotan Naluzotan may decrease the antihypertensive activities of Metolazone.
Cariprazine Cariprazine may decrease the antihypertensive activities of Metolazone.
Mianserin Mianserin may decrease the antihypertensive activities of Metolazone.
Nylidrin Nylidrin may decrease the antihypertensive activities of Metolazone.
Solabegron Solabegron may decrease the antihypertensive activities of Metolazone.
Asenapine Asenapine may decrease the antihypertensive activities of Metolazone.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Metolazone.
Vilazodone Vilazodone may decrease the antihypertensive activities of Metolazone.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Metolazone.
Xylometazoline Xylometazoline may decrease the antihypertensive activities of Metolazone.
Isometheptene Isometheptene may decrease the antihypertensive activities of Metolazone.
Naphazoline Naphazoline may decrease the antihypertensive activities of Metolazone.
Saralasin Saralasin may decrease the antihypertensive activities of Metolazone.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Metolazone.
Cinitapride Cinitapride may decrease the antihypertensive activities of Metolazone.
Lurasidone Lurasidone may decrease the antihypertensive activities of Metolazone.
Tyramine Tyramine may decrease the antihypertensive activities of Metolazone.
Adrafinil Adrafinil may decrease the antihypertensive activities of Metolazone.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Metolazone.
Etilefrine Etilefrine may decrease the antihypertensive activities of Metolazone.
Butriptyline Butriptyline may decrease the antihypertensive activities of Metolazone.
Cannabidiol Cannabidiol may decrease the antihypertensive activities of Metolazone.
Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Metolazone.
Cirazoline Cirazoline may decrease the antihypertensive activities of Metolazone.
Synephrine Synephrine may decrease the antihypertensive activities of Metolazone.
Tianeptine Tianeptine may decrease the antihypertensive activities of Metolazone.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Metolazone.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Metolazone.
Dihydroergocornine Dihydroergocornine may decrease the antihypertensive activities of Metolazone.
Amitraz Amitraz may decrease the antihypertensive activities of Metolazone.
Medetomidine Medetomidine may decrease the antihypertensive activities of Metolazone.
Xylazine Xylazine may decrease the antihypertensive activities of Metolazone.

Target Protein

Solute carrier family 12 member 3 SLC12A3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16189620
    Rosenberg J, Gustafsson F, Galatius S, Hildebrandt PR: Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature. Cardiovasc Drugs Ther. 2005 Aug;19(4):301-6.

Contoh Produk & Brand

Produk: 98 • International brands: 12
Produk
  • Metolazone
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved
  • Metolazone
    Tablet • 5 mg/1 • Oral • US • Generic • Approved
  • Metolazone
    Tablet • 10 mg/1 • Oral • US • Generic • Approved
  • Metolazone
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved
  • Metolazone
    Tablet • 5 mg/1 • Oral • US • Generic • Approved
  • Metolazone
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved
  • Metolazone
    Tablet • 5 mg/1 • Oral • US • Generic • Approved
  • Metolazone
    Tablet • 2.5 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 98 produk.
International Brands
  • Diulo
  • Diurem — Cipla
  • Metadure — Micro Labs
  • Metenix — IFET
  • Metolaz — Navana
  • Metoral — Dr. Reddy's
  • Metoz — Centaur
  • Metozone — Ying Yuan
  • Mykrox — Celltech
  • Pavedal — Pharma Investi

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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