Peringatan Keamanan

Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.

Albendazole

DB00518

small molecule approved vet_approved

Deskripsi

A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)

Struktur Molekul 2D

Berat 265.331
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Terminal elimination half-life ranges from 8 to 12 hours (single dose, 400mg).
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Oral bioavailability appears to be enhanced when coadministered with a fatty meal (estimated fat content 40 g)

Metabolisme

Hepatic. Rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine.

Rute Eliminasi

Albendazole is rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine. Urinary excretion of albendazole sulfoxide is a minor elimination pathway with less than 1% of the dose recovered in the urine. Biliary elimination presumably accounts for a portion of the elimination as evidenced by biliary concentrations of albendazole sulfoxide similar to those achieved in plasma.

Interaksi Makanan

1 Data
  • 1. Take with a high fat meal. A high fat meal increases solubility and absorption. Take with food when treating systemic infections.

Interaksi Obat

739 Data
Deferasirox The serum concentration of Albendazole can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Albendazole can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Albendazole can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Albendazole can be decreased when it is combined with Teriflunomide.
Dabrafenib The serum concentration of Albendazole can be decreased when it is combined with Dabrafenib.
Luliconazole The serum concentration of Albendazole can be increased when it is combined with Luliconazole.
Phenytoin The serum concentration of the active metabolites of Albendazole can be reduced when Albendazole is used in combination with Phenytoin resulting in a loss in efficacy.
Fosphenytoin The serum concentration of the active metabolites of Albendazole can be reduced when Albendazole is used in combination with Fosphenytoin resulting in a loss in efficacy.
Bendamustine The serum concentration of Bendamustine can be increased when it is combined with Albendazole.
Pirfenidone The metabolism of Pirfenidone can be increased when combined with Albendazole.
Abiraterone The serum concentration of Albendazole can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Albendazole can be increased when combined with Cyproterone acetate.
Lumacaftor The serum concentration of Albendazole can be decreased when it is combined with Lumacaftor.
Bexarotene The metabolism of Albendazole can be increased when combined with Bexarotene.
Bosentan The metabolism of Albendazole can be increased when combined with Bosentan.
Nafcillin The metabolism of Albendazole can be increased when combined with Nafcillin.
Avasimibe The metabolism of Albendazole can be increased when combined with Avasimibe.
Echinacea The metabolism of Albendazole can be increased when combined with Echinacea.
Dexamethasone acetate The metabolism of Albendazole can be increased when combined with Dexamethasone acetate.
Ramelteon The metabolism of Ramelteon can be increased when combined with Albendazole.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Albendazole.
Ethanol The metabolism of Ethanol can be increased when combined with Albendazole.
Etoricoxib The metabolism of Etoricoxib can be increased when combined with Albendazole.
Enasidenib The metabolism of Enasidenib can be increased when combined with Albendazole.
Bortezomib The metabolism of Bortezomib can be increased when combined with Albendazole.
Caffeine The metabolism of Caffeine can be increased when combined with Albendazole.
Lidocaine The metabolism of Lidocaine can be increased when combined with Albendazole.
Mexiletine The metabolism of Mexiletine can be increased when combined with Albendazole.
Alosetron The metabolism of Alosetron can be increased when combined with Albendazole.
Theophylline The metabolism of Theophylline can be increased when combined with Albendazole.
Warfarin The metabolism of Warfarin can be increased when combined with Albendazole.
Pimozide The metabolism of Pimozide can be increased when combined with Albendazole.
Aminophylline The metabolism of Aminophylline can be increased when combined with Albendazole.
Dasatinib The metabolism of Dasatinib can be increased when combined with Albendazole.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Albendazole.
Promazine The metabolism of Promazine can be increased when combined with Albendazole.
Paroxetine The metabolism of Paroxetine can be increased when combined with Albendazole.
Thiabendazole The metabolism of Thiabendazole can be increased when combined with Albendazole.
Lomefloxacin The metabolism of Lomefloxacin can be increased when combined with Albendazole.
Selegiline The metabolism of Selegiline can be increased when combined with Albendazole.
Primaquine The metabolism of Primaquine can be increased when combined with Albendazole.
Propafenone The metabolism of Propafenone can be increased when combined with Albendazole.
Temafloxacin The metabolism of Temafloxacin can be increased when combined with Albendazole.
Estrone sulfate The metabolism of Estrone sulfate can be increased when combined with Albendazole.
Dihydralazine The metabolism of Dihydralazine can be increased when combined with Albendazole.
Betaxolol The metabolism of Betaxolol can be increased when combined with Albendazole.
Anagrelide The metabolism of Anagrelide can be increased when combined with Albendazole.
Carmustine The metabolism of Carmustine can be increased when combined with Albendazole.
Disopyramide The metabolism of Disopyramide can be increased when combined with Albendazole.
Ropivacaine The metabolism of Ropivacaine can be increased when combined with Albendazole.
Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Albendazole.
Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Albendazole.
Mirtazapine The metabolism of Mirtazapine can be increased when combined with Albendazole.
Triamterene The metabolism of Triamterene can be increased when combined with Albendazole.
Entecavir The metabolism of Entecavir can be increased when combined with Albendazole.
Nabumetone The metabolism of Nabumetone can be increased when combined with Albendazole.
Flutamide The metabolism of Flutamide can be increased when combined with Albendazole.
Fluorouracil The metabolism of Fluorouracil can be increased when combined with Albendazole.
Cinnarizine The metabolism of Cinnarizine can be increased when combined with Albendazole.
Diclofenac The metabolism of Diclofenac can be increased when combined with Albendazole.
Guanabenz The metabolism of Guanabenz can be increased when combined with Albendazole.
Pemetrexed The metabolism of Pemetrexed can be increased when combined with Albendazole.
Riluzole The metabolism of Riluzole can be increased when combined with Albendazole.
Zileuton The metabolism of Zileuton can be increased when combined with Albendazole.
Acyclovir The metabolism of Acyclovir can be increased when combined with Albendazole.
Naproxen The metabolism of Naproxen can be increased when combined with Albendazole.
Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Albendazole.
Perphenazine The metabolism of Perphenazine can be increased when combined with Albendazole.
Dacarbazine The metabolism of Dacarbazine can be increased when combined with Albendazole.
Terbinafine The metabolism of Terbinafine can be increased when combined with Albendazole.
Maprotiline The metabolism of Maprotiline can be increased when combined with Albendazole.
Azathioprine The metabolism of Azathioprine can be increased when combined with Albendazole.
Frovatriptan The metabolism of Frovatriptan can be increased when combined with Albendazole.
Levobupivacaine The metabolism of Levobupivacaine can be increased when combined with Albendazole.
Cinacalcet The metabolism of Cinacalcet can be increased when combined with Albendazole.
Tocainide The metabolism of Tocainide can be increased when combined with Albendazole.
Praziquantel The metabolism of Praziquantel can be increased when combined with Albendazole.
Melatonin The metabolism of Melatonin can be increased when combined with Albendazole.
Hesperetin The metabolism of Hesperetin can be increased when combined with Albendazole.
Carvedilol The metabolism of Carvedilol can be increased when combined with Albendazole.
Cilostazol The metabolism of Cilostazol can be increased when combined with Albendazole.
Dexfenfluramine The metabolism of Dexfenfluramine can be increased when combined with Albendazole.
Oxtriphylline The metabolism of Oxtriphylline can be increased when combined with Albendazole.
Rasagiline The metabolism of Rasagiline can be increased when combined with Albendazole.
Theobromine The metabolism of Theobromine can be increased when combined with Albendazole.
Fenethylline The metabolism of Fenethylline can be increased when combined with Albendazole.
Bromazepam The metabolism of Bromazepam can be increased when combined with Albendazole.
Thiothixene The metabolism of Thiothixene can be increased when combined with Albendazole.
Genistein The metabolism of Genistein can be increased when combined with Albendazole.
8-azaguanine The metabolism of 8-azaguanine can be increased when combined with Albendazole.
Xanthine The metabolism of Xanthine can be increased when combined with Albendazole.
9-Methylguanine The metabolism of 9-Methylguanine can be increased when combined with Albendazole.
Peldesine The metabolism of Peldesine can be increased when combined with Albendazole.
Phenacetin The metabolism of Phenacetin can be increased when combined with Albendazole.
Hypoxanthine The metabolism of Hypoxanthine can be increased when combined with Albendazole.
9-Deazaguanine The metabolism of 9-Deazaguanine can be increased when combined with Albendazole.
Flunarizine The metabolism of Flunarizine can be increased when combined with Albendazole.
Lorcaserin The metabolism of Lorcaserin can be increased when combined with Albendazole.
Lofexidine The metabolism of Lofexidine can be increased when combined with Albendazole.
Mianserin The metabolism of Mianserin can be increased when combined with Albendazole.

Target Protein

Tubulin beta-2 chain
Tubulin alpha-1A chain TUBA1A
Tubulin beta-4B chain TUBB4B
Fumarate reductase flavoprotein subunit

Referensi & Sumber

Synthesis reference: Gyurik, R.J. and Theodorides, VJ.; US. Patent 3,915,986; October 28,1975; assigned to Smith Kline Corp.
Artikel (PubMed)
  • PMID: 17350811
    Molina AJ, Merino G, Prieto JG, Real R, Mendoza G, Alvarez AI: Absorption and metabolism of albendazole after intestinal ischemia/reperfusion. Eur J Pharm Sci. 2007 May;31(1):16-24. Epub 2007 Feb 6.
  • PMID: 11110097
    Oxberry ME, Reynoldson JA, Thompson RC: The binding and distribution of albendazole and its principal metabolites in Giardia duodenalis. J Vet Pharmacol Ther. 2000 Jun;23(3):113-20.
  • PMID: 11343808
    Ramirez T, Benitez-Bribiesca L, Ostrosky-Wegman P, Herrera LA: In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes. Arch Med Res. 2001 Mar-Apr;32(2):119-22.
  • PMID: 8228321
    Haque A, Hollister WS, Willcox A, Canning EU: The antimicrosporidial activity of albendazole. J Invertebr Pathol. 1993 Sep;62(2):171-7.

Contoh Produk & Brand

Produk: 32 • International brands: 27
Produk
  • Albendazole
    Tablet, film coated • 200 mg/1 • Oral • US • Approved
  • Albendazole
    Tablet, film coated • 200 mg/1 • Oral • US • Approved
  • Albendazole
    Tablet • 200 mg/1 • Oral • US • Generic • Approved
  • Albendazole
    Tablet • 200 mg/1 • Oral • US • Generic • Approved
  • Albendazole
    Tablet, film coated • 200 mg/1 • Oral • US • Generic • Approved
  • Albendazole
    Tablet, film coated • 200 mg/1 • Oral • US • Generic • Approved
  • Albendazole
    Tablet • 200 mg/1 • Oral • US • Generic • Approved
  • Albendazole
    Tablet, film coated • 200 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 32 produk.
International Brands
  • Abentel — Aristopharma
  • ABZ — Indoco
  • Acure — Pharmix
  • Adazol — Roemmers
  • AL — Radicura
  • Band — Vensat
  • Bandy — Mankind
  • Bazole — Neutro Pharma
  • Ben-A — Acme
  • Benrod — Invision

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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