Peringatan Keamanan

In the rare event of cimetidine overdose, it is vital to maintain the airway and cardiovascular status.A226848 The patient should be closely monitored and provided with symptomatic and supportive treatment as needed.A226848 Interventions such as gastric lavage and administration of activated charcoal may be initiated if deemed appropriate and necessary.A226848

Cimetidine

DB00501

small molecule approved investigational

Deskripsi

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.

Struktur Molekul 2D

Berat 252.339
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Cimetidine's half-life is estimated to be around 2 hours.[L30280]
Volume Distribusi The volume of distribution of cimetidine is reported to be 1 L/kg.[A226958]
Klirens (Clearance) Cimetidine's reported systemic clearance value is approximately 500-600 ml/min.[A226958]

Absorpsi

Two peak plasma concentrations are often observed after oral administration of cimetidine, likely as a result of discontinuous absorption in the gastrointestinal tract.A226958 In healthy patients, the absolute bioavailability of cimetidine is approximately 60%; however, the bioavailability can be as high as 70% in patients with peptic ulcer disease.A226958 Overall, rates of bioavailability are much more variable in patients with peptic ulcer disease.A226958

Metabolisme

After intravenous administration of cimetidine, the majority of the parent drug (58-77%) is eliminated unchanged in the urine.A226918,L30280 Cimetidine’s primary metabolite is cimetidine sulfoxide and represents an estimated 10-15% of total elimination.A226918,A226958 Researchers have also identified a minor cimetidine metabolite with a hydroxylated methyl group on the imidazole ring which represents only 4% of total elimination.A226918,A226958 Both cytochrome P450 enzymes and flavin-containing monooxygenases are implicated in the metabolism of cimetidine, although it is unclear which specific enzymes are involved.A226933 Cimetidine is a well known enzyme inhibitor and may impair the metabolism of certain co-administered medications.A226943

Rute Eliminasi

Cimetidine is excreted primarily in the urine.L30280

Interaksi Makanan

1 Data
  • 1. Take with food. Food increases bioavailability. For prophylaxis of gastric symptoms, take cimetidine 30-60 minutes prior to food administration.

Interaksi Obat

1555 Data
Tizanidine The serum concentration of Tizanidine can be increased when it is combined with Cimetidine.
Sulfamethoxazole Cimetidine may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
Glycochenodeoxycholic Acid Cimetidine may decrease the excretion rate of Glycochenodeoxycholic Acid which could result in a higher serum level.
Pravastatin Cimetidine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Diethylstilbestrol Cimetidine may decrease the excretion rate of Diethylstilbestrol which could result in a higher serum level.
Flucloxacillin Cimetidine may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Rosiglitazone Cimetidine may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Spironolactone Spironolactone may increase the excretion rate of Cimetidine which could result in a lower serum level and potentially a reduction in efficacy.
Cerivastatin Cimetidine may decrease the excretion rate of Cerivastatin which could result in a higher serum level.
Atropine Cimetidine may decrease the excretion rate of Atropine which could result in a higher serum level.
Diclofenac Cimetidine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Efavirenz Cimetidine may decrease the excretion rate of Efavirenz which could result in a higher serum level.
Losartan The metabolism of Losartan can be decreased when combined with Cimetidine.
Fluorescein Cimetidine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Nitrofurantoin Cimetidine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Naproxen Cimetidine may decrease the excretion rate of Naproxen which could result in a higher serum level.
Disulfiram Cimetidine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Cefaclor Cimetidine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Mifepristone Cimetidine may decrease the excretion rate of Mifepristone which could result in a higher serum level.
Tinidazole Cimetidine may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Repaglinide Cimetidine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Telmisartan Cimetidine may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Ezetimibe Cimetidine may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Dipyridamole Cimetidine may decrease the excretion rate of Dipyridamole which could result in a higher serum level.
Fenofibrate Cimetidine may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Rosuvastatin Cimetidine may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Sulfinpyrazone Cimetidine may decrease the excretion rate of Sulfinpyrazone which could result in a higher serum level.
Ofloxacin Cimetidine may decrease the excretion rate of Ofloxacin which could result in a higher serum level.
Clarithromycin Cimetidine may decrease the excretion rate of Clarithromycin which could result in a higher serum level.
Taurocholic acid Cimetidine may decrease the excretion rate of Taurocholic acid which could result in a higher serum level.
Prasterone sulfate Cimetidine may decrease the excretion rate of Prasterone sulfate which could result in a higher serum level.
Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cimetidine is combined with Pitavastatin.
Indocyanine green acid form Cimetidine may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.
Benzbromarone Cimetidine may decrease the excretion rate of Benzbromarone which could result in a higher serum level.
Pilsicainide Cimetidine may decrease the excretion rate of Pilsicainide which could result in a higher serum level.
Dihydroergocristine Cimetidine may decrease the excretion rate of Dihydroergocristine which could result in a higher serum level.
Glycyrrhizic acid Cimetidine may decrease the excretion rate of Glycyrrhizic acid which could result in a higher serum level.
Indomethacin Cimetidine may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Loratadine Cimetidine may decrease the excretion rate of Loratadine which could result in a higher serum level.
Belantamab mafodotin Cimetidine may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Lomitapide The metabolism of Lomitapide can be decreased when combined with Cimetidine.
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Cimetidine.
Nicotine Cimetidine may decrease the excretion rate of Nicotine which could result in a higher serum level.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Cimetidine.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Cimetidine.
Dofetilide Cimetidine may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Cimetidine.
Atazanavir Cimetidine can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefditoren The serum concentration of Cefditoren can be decreased when it is combined with Cimetidine.
Dabigatran etexilate Cimetidine can cause a decrease in the absorption of Dabigatran etexilate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dabrafenib Cimetidine can cause a decrease in the absorption of Dabrafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erlotinib Cimetidine can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ledipasvir Cimetidine can cause a decrease in the absorption of Ledipasvir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pazopanib Cimetidine can cause a decrease in the absorption of Pazopanib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Riociguat Cimetidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colchicine The metabolism of Colchicine can be decreased when combined with Cimetidine.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Cimetidine.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Cimetidine.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Cimetidine.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Cimetidine.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Cimetidine.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Cimetidine.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Cimetidine.
Glimepiride The serum concentration of Glimepiride can be increased when it is combined with Cimetidine.
Acetohexamide The serum concentration of Acetohexamide can be increased when it is combined with Cimetidine.
Chlorpropamide The serum concentration of Chlorpropamide can be increased when it is combined with Cimetidine.
Tolazamide The serum concentration of Tolazamide can be increased when it is combined with Cimetidine.
Glyburide The serum concentration of Glyburide can be increased when it is combined with Cimetidine.
Glipizide The serum concentration of Glipizide can be increased when it is combined with Cimetidine.
Gliclazide The serum concentration of Gliclazide can be increased when it is combined with Cimetidine.
Tolbutamide The serum concentration of Tolbutamide can be increased when it is combined with Cimetidine.
Gliquidone The serum concentration of Gliquidone can be increased when it is combined with Cimetidine.
Glisoxepide The serum concentration of Glisoxepide can be increased when it is combined with Cimetidine.
Glibornuride The serum concentration of Glibornuride can be increased when it is combined with Cimetidine.
Carbutamide The serum concentration of Carbutamide can be increased when it is combined with Cimetidine.
Metahexamide The serum concentration of Metahexamide can be increased when it is combined with Cimetidine.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Cimetidine.
Phenytoin The serum concentration of Phenytoin can be increased when it is combined with Cimetidine.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with Cimetidine.
Carmustine Cimetidine may increase the myelosuppressive activities of Carmustine.
Isradipine The serum concentration of Isradipine can be increased when it is combined with Cimetidine.
Diltiazem The serum concentration of Diltiazem can be increased when it is combined with Cimetidine.
Trimethadione The serum concentration of Trimethadione can be increased when it is combined with Cimetidine.
Amlodipine The serum concentration of Amlodipine can be increased when it is combined with Cimetidine.
Nimodipine The serum concentration of Nimodipine can be increased when it is combined with Cimetidine.
Nisoldipine The serum concentration of Nisoldipine can be increased when it is combined with Cimetidine.
Lercanidipine The serum concentration of Lercanidipine can be increased when it is combined with Cimetidine.
Cinnarizine The serum concentration of Cinnarizine can be increased when it is combined with Cimetidine.
Ethosuximide The serum concentration of Ethosuximide can be increased when it is combined with Cimetidine.
Nicardipine The serum concentration of Nicardipine can be increased when it is combined with Cimetidine.
Magnesium sulfate The serum concentration of Magnesium sulfate can be increased when it is combined with Cimetidine.
Verapamil The serum concentration of Verapamil can be increased when it is combined with Cimetidine.
Loperamide The metabolism of Loperamide can be decreased when combined with Cimetidine.
Zonisamide The serum concentration of Zonisamide can be increased when it is combined with Cimetidine.
Felodipine The serum concentration of Felodipine can be increased when it is combined with Cimetidine.
Nitrendipine The serum concentration of Nitrendipine can be increased when it is combined with Cimetidine.
Perhexiline The serum concentration of Perhexiline can be increased when it is combined with Cimetidine.
Nifedipine The serum concentration of Nifedipine can be increased when it is combined with Cimetidine.
Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Cimetidine.
Bepridil The serum concentration of Bepridil can be increased when it is combined with Cimetidine.

Target Protein

Histamine H2 receptor HRH2

Referensi & Sumber

Synthesis reference: Saburo Uchikuga, Tomoyasu Tashiro, Yasuko Osawa, "Process for preparing the H.sub.2 -receptor antagonist cimetidine." U.S. Patent US4413129, issued March, 1972.
Artikel (PubMed)
  • PMID: 1988774
    Michnovicz JJ, Galbraith RA: Cimetidine inhibits catechol estrogen metabolism in women. Metabolism. 1991 Feb;40(2):170-4.
  • PMID: 7059413
    Larsson R, Erlanson P, Bodemar G, Walan A, Bertler A, Fransson L, Norlander B: The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. Br J Clin Pharmacol. 1982 Feb;13(2):163-70. doi: 10.1111/j.1365-2125.1982.tb01351.x.
  • PMID: 9733675
    Lu X, Li C, Fleisher D: Cimetidine sulfoxidation in small intestinal microsomes. Drug Metab Dispos. 1998 Sep;26(9):940-2.
  • PMID: 3935464
    Hoensch HP, Hutzel H, Kirch W, Ohnhaus EE: Isolation of human hepatic microsomes and their inhibition by cimetidine and ranitidine. Eur J Clin Pharmacol. 1985;29(2):199-206. doi: 10.1007/BF00547422.
  • PMID: 31334975
    Pino MA, Azer SA: Cimetidine .
  • PMID: 6418428
    Somogyi A, Gugler R: Clinical pharmacokinetics of cimetidine. Clin Pharmacokinet. 1983 Nov-Dec;8(6):463-95. doi: 10.2165/00003088-198308060-00001.

Contoh Produk & Brand

Produk: 153 • International brands: 6
Produk
  • Acid Reducer
    Tablet • 200 mg/1 • Oral • US • Generic • OTC • Approved
  • Acid Reducer
    Tablet, film coated • 200 mg/1 • Oral • US • Generic • OTC • Approved
  • Apo-cimetidine Oral Solution
    Liquid • 300 mg / 5 mL • Oral • Canada • Generic • Approved
  • Basic Care Acid Reducer
    Tablet, film coated • 200 mg/1 • Oral • US • Generic • OTC • Approved
  • Cimetidine
    Tablet, film coated • 400 mg/1 • Oral • US • Generic • Approved
  • Cimetidine
    Tablet, film coated • 800 mg/1 • Oral • US • Generic • Approved
  • Cimetidine
    Tablet • 400 mg/1 • Oral • US • Generic • Approved
  • Cimetidine
    Tablet • 300 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 153 produk.
International Brands
  • Cimetag — Julphar
  • Tagamet HB 200 — GlaxoSmithKline
  • Tagamet HB200 — GlaxoSmithKline
  • Ulcedine
  • Ulcerfen — Finadiet
  • Ulcimet — Farmasa

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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