Peringatan Keamanan

Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.

Tolmetin

DB00500

small molecule approved

Deskripsi

A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.

Struktur Molekul 2D

Berat 257.2845
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Biphasic elimination from the plasma consisting of a rapid phase with a half-life of one to 2 hours followed by a slower phase with a half-life of about 5 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.

Metabolisme

Essentially all of the administered dose is recovered in the urine in 24 hours either as an inactive oxidative metabolite or as conjugates of tolmetin.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Ingesting alcohol may increase the risk of developing an ulcer, or gastrointestinal bleed.
  • 2. Take with or without food. Food (or milk) can decrease oral bioavailability by 16%. Tolmetin may be taken with food to reduce gastrointestinal upset, but it may reduce tolmetin serum levels by 50%.

Interaksi Obat

1407 Data
Amlodipine Tolmetin may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Tolmetin.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Tolmetin.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Tolmetin.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Tolmetin.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Tolmetin.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Tolmetin.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Tolmetin.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Tolmetin.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Tolmetin.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Tolmetin.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Tolmetin.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Tolmetin.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Tolmetin.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Tolmetin.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Tolmetin.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Tolmetin.
Doxapram The risk or severity of hypertension can be increased when Tolmetin is combined with Doxapram.
Atropine The risk or severity of hypertension can be increased when Tolmetin is combined with Atropine.
Lisuride The risk or severity of hypertension can be increased when Tolmetin is combined with Lisuride.
Linezolid The risk or severity of hypertension can be increased when Tolmetin is combined with Linezolid.
Metaraminol The risk or severity of hypertension can be increased when Tolmetin is combined with Metaraminol.
Furazolidone The risk or severity of hypertension can be increased when Tolmetin is combined with Furazolidone.
Epinephrine The risk or severity of hypertension can be increased when Tolmetin is combined with Epinephrine.
Thioridazine The risk or severity of hypertension can be increased when Tolmetin is combined with Thioridazine.
Ergotamine The risk or severity of hypertension can be increased when Tolmetin is combined with Ergotamine.
Nicergoline The risk or severity of hypertension can be increased when Tolmetin is combined with Nicergoline.
Sufentanil The risk or severity of hypertension can be increased when Tolmetin is combined with Sufentanil.
Methoxamine The risk or severity of hypertension can be increased when Tolmetin is combined with Methoxamine.
Risperidone The risk or severity of hypertension can be increased when Tolmetin is combined with Risperidone.
Tranylcypromine The risk or severity of hypertension can be increased when Tolmetin is combined with Tranylcypromine.
Isoflurane The risk or severity of hypertension can be increased when Tolmetin is combined with Isoflurane.
Propiomazine The risk or severity of hypertension can be increased when Tolmetin is combined with Propiomazine.
Alfentanil The risk or severity of hypertension can be increased when Tolmetin is combined with Alfentanil.
Minaprine The risk or severity of hypertension can be increased when Tolmetin is combined with Minaprine.
Orciprenaline The risk or severity of hypertension can be increased when Tolmetin is combined with Orciprenaline.
Propofol The risk or severity of hypertension can be increased when Tolmetin is combined with Propofol.
Phenmetrazine The risk or severity of hypertension can be increased when Tolmetin is combined with Phenmetrazine.
Trifluoperazine The risk or severity of hypertension can be increased when Tolmetin is combined with Trifluoperazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Tolmetin is combined with Pseudoephedrine.
Benzphetamine The risk or severity of hypertension can be increased when Tolmetin is combined with Benzphetamine.
Ritodrine The risk or severity of hypertension can be increased when Tolmetin is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Tolmetin is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Tolmetin is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Tolmetin is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Tolmetin is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Tolmetin is combined with Diethylpropion.
Salmeterol The risk or severity of hypertension can be increased when Tolmetin is combined with Salmeterol.
Naratriptan The risk or severity of hypertension can be increased when Tolmetin is combined with Naratriptan.
Formoterol The risk or severity of hypertension can be increased when Tolmetin is combined with Formoterol.
Frovatriptan The risk or severity of hypertension can be increased when Tolmetin is combined with Frovatriptan.
Methoxyflurane The risk or severity of hypertension can be increased when Tolmetin is combined with Methoxyflurane.
Selegiline The risk or severity of hypertension can be increased when Tolmetin is combined with Selegiline.
Ergoloid mesylate The risk or severity of hypertension can be increased when Tolmetin is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Tolmetin is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Tolmetin is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Tolmetin is combined with Dutasteride.
Halothane The risk or severity of hypertension can be increased when Tolmetin is combined with Halothane.
Moclobemide The risk or severity of hypertension can be increased when Tolmetin is combined with Moclobemide.
Pergolide The risk or severity of hypertension can be increased when Tolmetin is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Tolmetin is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Tolmetin is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Tolmetin is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Tolmetin is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Tolmetin is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Tolmetin is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Tolmetin is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Tolmetin is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Tolmetin is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Tolmetin is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Tolmetin is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Tolmetin is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Tolmetin is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Tolmetin is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Tolmetin is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Tolmetin is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Tolmetin is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Tolmetin is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Tolmetin is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Tolmetin is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Tolmetin is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Tolmetin is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Tolmetin is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Tolmetin is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Tolmetin is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Tolmetin is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Tolmetin is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Tolmetin is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Tolmetin is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Tolmetin is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Tolmetin is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Tolmetin is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Tolmetin is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Tolmetin is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Tolmetin is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Tolmetin is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Tolmetin is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Tolmetin is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Tolmetin is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Tolmetin is combined with Iloperidone.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1

Referensi & Sumber

Contoh Produk & Brand

Produk: 17 • International brands: 2
Produk
  • Novo-tolmetin Capsules 400mg
    Capsule • 400 mg • Oral • Canada • Generic • Approved
  • Tolectin
    Tablet, film coated • 600 mg/1 • Oral • US • Generic • Approved
  • Tolectin 200 Tab 200mg
    Tablet • 245 mg • Oral • Canada • Approved
  • Tolectin 400 Cap 400mg
    Capsule • 400 mg / cap • Oral • Canada • Approved
  • Tolectin Tab 600mg
    Tablet • 600 mg • Oral • Canada • Approved
  • Tolmetin Sodium
    Tablet, film coated • 600 mg/1 • Oral • US • Generic • Approved
  • Tolmetin Sodium
    Capsule • 400 mg/1 • Oral • US • Generic • Approved
  • Tolmetin Sodium
    Tablet, film coated • 600 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 17 produk.
International Brands
  • Tolectin — Teva
  • Tolectin DS — Teva

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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