Peringatan Keamanan

In animal studies with flutamide alone, signs of overdose included hypoactivity, piloerection, slow respiration, ataxia, and/or lacrimation, anorexia, tranquilization, emesis, and methemoglobinemia.

Flutamide

DB00499

small molecule approved investigational

Deskripsi

An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Struktur Molekul 2D

Berat 276.2118
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The plasma half-life for the alpha-hydroxylated metabolite of flutamide (an active metabolite) is approximately 6 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and completely absorbed.

Metabolisme

Flutamide is rapidly and extensively metabolized, with flutamide comprising only 2.5% of plasma radioactivity 1 hour after administration.

Rute Eliminasi

Flutamide and its metabolites are excreted mainly in the urine with only 4.2% of a single dose excreted in the feces over 72 hours.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1203 Data
Deferasirox The serum concentration of Flutamide can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Flutamide can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Flutamide can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Flutamide can be decreased when it is combined with Teriflunomide.
Prilocaine The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Prilocaine.
Abiraterone The serum concentration of Flutamide can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Flutamide can be increased when combined with Cyproterone acetate.
Dapsone The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Flutamide.
Choline C 11 Flutamide may decrease effectiveness of Choline C 11 as a diagnostic agent.
Capromab pendetide Flutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Albendazole The metabolism of Flutamide can be increased when combined with Albendazole.
Rifampin The metabolism of Flutamide can be increased when combined with Rifampicin.
Primidone The metabolism of Flutamide can be increased when combined with Primidone.
Caffeine The metabolism of Flutamide can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Flutamide can be decreased when combined with Moxifloxacin.
Mexiletine The metabolism of Flutamide can be decreased when combined with Mexiletine.
Alosetron The metabolism of Flutamide can be decreased when combined with Alosetron.
Gatifloxacin The metabolism of Flutamide can be decreased when combined with Gatifloxacin.
Simeprevir The metabolism of Flutamide can be decreased when combined with Simeprevir.
Lobeglitazone The metabolism of Flutamide can be decreased when combined with Lobeglitazone.
Pazufloxacin The metabolism of Flutamide can be decreased when combined with Pazufloxacin.
Imipramine The metabolism of Flutamide can be decreased when combined with Imipramine.
Osilodrostat The metabolism of Flutamide can be decreased when combined with Osilodrostat.
Osimertinib The serum concentration of Flutamide can be decreased when it is combined with Osimertinib.
Vemurafenib The serum concentration of Flutamide can be increased when it is combined with Vemurafenib.
Pitolisant The serum concentration of Flutamide can be decreased when it is combined with Pitolisant.
Icosapent Icosapent may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Flutamide which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Flutamide which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Flutamide which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Flutamide which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Flutamide which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Meloxicam The risk or severity of methemoglobinemia can be increased when Flutamide is combined with Meloxicam.
Carprofen Carprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Flutamide which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Flutamide which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Flutamide which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Flutamide which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Flutamide which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Flutamide which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Flutamide which could result in a higher serum level.

Target Protein

Androgen receptor AR
Aryl hydrocarbon receptor AHR
Nuclear receptor subfamily 1 group I member 2 NR1I2

Referensi & Sumber

Synthesis reference: Jack Lawrence James, Louis Frank Molnar, Jr., Tania E. Toney-Parker, "Processes for preparing flutamide compounds and compounds prepared by such processes." U.S. Patent US 6,228,401, issued November, 1976.

Contoh Produk & Brand

Produk: 23 • International brands: 15
Produk
  • Dom-flutamide
    Tablet • 250 mg / tab • Oral • Canada • Generic • Approved
  • Euflex
    Tablet • 250 mg • Oral • Canada • Approved
  • Eulexin
    Capsule • 125 mg/1 • Oral • US • Approved
  • Eulexin
    Capsule • 125 mg/1 • Oral • US • Generic • Approved
  • Eulexin
    Capsule • 125 mg/1 • Oral • US • Generic • Approved
  • Flutamide
    Capsule • 125 mg/1 • Oral • US • Generic • Approved
  • Flutamide
    Capsule • 125 mg/1 • Oral • US • Generic • Approved
  • Flutamide
    Capsule • 125 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 23 produk.
International Brands
  • Andraxan — CSC
  • Antipros — Medicamerc
  • Curestat — Advanced Pharmaceutical
  • Cytomid — Cipla
  • Dedile — Ivax
  • Drogenil — Bayer
  • Elbat — Genepharm
  • Etaconil — Nolver
  • Farostat — Orion
  • Flimutal — Cryopharma

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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