Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Apixaban | Apixaban may increase the anticoagulant activities of Phenindione. |
| Dabigatran etexilate | Dabigatran etexilate may increase the anticoagulant activities of Phenindione. |
| Dasatinib | The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Phenindione. |
| Deferasirox | The risk or severity of gastrointestinal bleeding can be increased when Phenindione is combined with Deferasirox. |
| Ursodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Ursodeoxycholic acid. |
| Glycochenodeoxycholic Acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Glycochenodeoxycholic Acid. |
| Cholic Acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Cholic Acid. |
| Glycocholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Glycocholic acid. |
| Deoxycholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Deoxycholic acid. |
| Taurocholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Taurocholic acid. |
| Obeticholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Obeticholic acid. |
| Chenodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Chenodeoxycholic acid. |
| Taurochenodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Taurochenodeoxycholic acid. |
| Tauroursodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Tauroursodeoxycholic acid. |
| Bamet-UD2 | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Bamet-UD2. |
| Dehydrocholic acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Dehydrocholic acid. |
| Hyodeoxycholic Acid | The risk or severity of bleeding and bruising can be increased when Phenindione is combined with Hyodeoxycholic Acid. |
| Edoxaban | The risk or severity of bleeding can be increased when Edoxaban is combined with Phenindione. |
| Ibrutinib | The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Phenindione. |
| Obinutuzumab | The risk or severity of bleeding and hemorrhage can be increased when Phenindione is combined with Obinutuzumab. |
| Rivaroxaban | Phenindione may increase the anticoagulant activities of Rivaroxaban. |
| Sugammadex | The risk or severity of bleeding and hemorrhage can be increased when Phenindione is combined with Sugammadex. |
| Tibolone | Tibolone may increase the anticoagulant activities of Phenindione. |
| Tipranavir | The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Phenindione. |
| Urokinase | Urokinase may increase the anticoagulant activities of Phenindione. |
| Vitamin E | Vitamin E may increase the anticoagulant activities of Phenindione. |
| Vorapaxar | The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Phenindione. |
| Gemcitabine | The therapeutic efficacy of Phenindione can be increased when used in combination with Gemcitabine. |
| Flunisolide | Flunisolide may increase the anticoagulant activities of Phenindione. |
| Beclomethasone dipropionate | Beclomethasone dipropionate may increase the anticoagulant activities of Phenindione. |
| Betamethasone | Betamethasone may increase the anticoagulant activities of Phenindione. |
| Fluticasone propionate | Fluticasone propionate may increase the anticoagulant activities of Phenindione. |
| Fluocinolone acetonide | Fluocinolone acetonide may increase the anticoagulant activities of Phenindione. |
| Prednisone | Prednisone may increase the anticoagulant activities of Phenindione. |
| Fludrocortisone | Fludrocortisone may increase the anticoagulant activities of Phenindione. |
| Hydrocortisone | Hydrocortisone may increase the anticoagulant activities of Phenindione. |
| Prednisolone | Prednisolone may increase the anticoagulant activities of Phenindione. |
| Methylprednisolone | Methylprednisolone may increase the anticoagulant activities of Phenindione. |
| Trilostane | Trilostane may increase the anticoagulant activities of Phenindione. |
| Budesonide | Budesonide may increase the anticoagulant activities of Phenindione. |
| Dexamethasone | Dexamethasone may increase the anticoagulant activities of Phenindione. |
| Corticotropin | Corticotropin may increase the anticoagulant activities of Phenindione. |
| Cortisone acetate | Cortisone acetate may increase the anticoagulant activities of Phenindione. |
| Paramethasone | Paramethasone may increase the anticoagulant activities of Phenindione. |
| Ciclesonide | Ciclesonide may increase the anticoagulant activities of Phenindione. |
| Aldosterone | Aldosterone may increase the anticoagulant activities of Phenindione. |
| Fluticasone furoate | Fluticasone furoate may increase the anticoagulant activities of Phenindione. |
| Fluprednidene | Fluprednidene may increase the anticoagulant activities of Phenindione. |
| Tixocortol | Tixocortol may increase the anticoagulant activities of Phenindione. |
| Fluprednisolone | Fluprednisolone may increase the anticoagulant activities of Phenindione. |
| Meprednisone | Meprednisone may increase the anticoagulant activities of Phenindione. |
| Dexamethasone isonicotinate | Dexamethasone isonicotinate may increase the anticoagulant activities of Phenindione. |
| Melengestrol | Melengestrol may increase the anticoagulant activities of Phenindione. |
| Deflazacort | Deflazacort may increase the anticoagulant activities of Phenindione. |
| Cortivazol | Cortivazol may increase the anticoagulant activities of Phenindione. |
| Prednylidene | Prednylidene may increase the anticoagulant activities of Phenindione. |
| Fluocortin | Fluocortin may increase the anticoagulant activities of Phenindione. |
| Fluperolone | Fluperolone may increase the anticoagulant activities of Phenindione. |
| Cloprednol | Cloprednol may increase the anticoagulant activities of Phenindione. |
| Fluclorolone | Fluclorolone may increase the anticoagulant activities of Phenindione. |
| Fluticasone | Fluticasone may increase the anticoagulant activities of Phenindione. |
| Mometasone furoate | Mometasone furoate may increase the anticoagulant activities of Phenindione. |
| Hydrocortisone acetate | Hydrocortisone acetate may increase the anticoagulant activities of Phenindione. |
| Hydrocortisone cypionate | Hydrocortisone cypionate may increase the anticoagulant activities of Phenindione. |
| Hydrocortisone succinate | Hydrocortisone succinate may increase the anticoagulant activities of Phenindione. |
| Prednisolone phosphate | Prednisolone phosphate may increase the anticoagulant activities of Phenindione. |
| Prednisolone hemisuccinate | Prednisolone hemisuccinate may increase the anticoagulant activities of Phenindione. |
| Methylprednisolone hemisuccinate | Methylprednisolone hemisuccinate may increase the anticoagulant activities of Phenindione. |
| Prednisone acetate | Prednisone acetate may increase the anticoagulant activities of Phenindione. |
| Clocortolone acetate | Clocortolone acetate may increase the anticoagulant activities of Phenindione. |
| Melengestrol acetate | Melengestrol acetate may increase the anticoagulant activities of Phenindione. |
| Betamethasone phosphate | Betamethasone phosphate may increase the anticoagulant activities of Phenindione. |
| Cortisone | Cortisone may increase the anticoagulant activities of Phenindione. |
| Clobetasol propionate | Clobetasol propionate may increase the anticoagulant activities of Phenindione. |
| Fluocinonide | Fluocinonide may increase the anticoagulant activities of Phenindione. |
| Hydrocortisone butyrate | Hydrocortisone butyrate may increase the anticoagulant activities of Phenindione. |
| Desoximetasone | Desoximetasone may increase the anticoagulant activities of Phenindione. |
| Mometasone | Mometasone may increase the anticoagulant activities of Phenindione. |
| Fluocortolone | Fluocortolone may increase the anticoagulant activities of Phenindione. |
| Prednisolone acetate | Prednisolone acetate may increase the anticoagulant activities of Phenindione. |
| Fluorometholone | Fluorometholone may increase the anticoagulant activities of Phenindione. |
| Difluocortolone | Difluocortolone may increase the anticoagulant activities of Phenindione. |
| Flumethasone | Flumethasone may increase the anticoagulant activities of Phenindione. |
| Methylprednisolone aceponate | Methylprednisolone aceponate may increase the anticoagulant activities of Phenindione. |
| Erlotinib | The serum concentration of Phenindione can be increased when it is combined with Erlotinib. |
| Acetaminophen | Acetaminophen may increase the anticoagulant activities of Phenindione. |
| Allopurinol | The risk or severity of bleeding can be increased when Allopurinol is combined with Phenindione. |
| Azathioprine | The therapeutic efficacy of Phenindione can be decreased when used in combination with Azathioprine. |
| Chloral hydrate | The protein binding of Phenindione can be decreased when combined with Chloral hydrate. |
| Methylphenidate | The metabolism of Phenindione can be decreased when combined with Methylphenidate. |
| Dexmethylphenidate | The metabolism of Phenindione can be decreased when combined with Dexmethylphenidate. |
| Disulfiram | Disulfiram may increase the anticoagulant activities of Phenindione. |
| Etacrynic acid | The protein binding of Phenindione can be decreased when combined with Etacrynic acid. |
| Ethotoin | The therapeutic efficacy of Phenindione can be increased when used in combination with Ethotoin. |
| Etoposide | The therapeutic efficacy of Phenindione can be increased when used in combination with Etoposide. |
| Exenatide | Exenatide can cause an increase in the absorption of Phenindione resulting in an increased serum concentration and potentially a worsening of adverse effects. |
| Gefitinib | Gefitinib may increase the anticoagulant activities of Phenindione. |
| Ginkgo biloba | Ginkgo biloba may increase the anticoagulant activities of Phenindione. |
| Glutethimide | The therapeutic efficacy of Phenindione can be decreased when used in combination with Glutethimide. |
| Ifosfamide | The risk or severity of bleeding can be increased when Ifosfamide is combined with Phenindione. |