Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Oral rat LD50 is over 20,000 mg/kg while intravenous rat LD50 is over 7,000 mg/kg.
Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Probenecid | The serum concentration of Cefotaxime can be increased when it is combined with Probenecid. |
| Foscarnet | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Foscarnet. |
| Mannitol | The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefotaxime. |
| Tenofovir disoproxil | Cefotaxime may increase the nephrotoxic activities of Tenofovir disoproxil. |
| Tenofovir alafenamide | Cefotaxime may increase the nephrotoxic activities of Tenofovir alafenamide. |
| Tenofovir | Cefotaxime may increase the nephrotoxic activities of Tenofovir. |
| Succinic acid | The excretion of Succinic acid can be decreased when combined with Cefotaxime. |
| Citrulline | The excretion of Citrulline can be decreased when combined with Cefotaxime. |
| Pravastatin | The excretion of Pravastatin can be decreased when combined with Cefotaxime. |
| Aminohippuric acid | The excretion of Aminohippuric acid can be decreased when combined with Cefotaxime. |
| Zidovudine | The excretion of Zidovudine can be decreased when combined with Cefotaxime. |
| Cefdinir | The excretion of Cefdinir can be decreased when combined with Cefotaxime. |
| Leucovorin | The excretion of Leucovorin can be decreased when combined with Cefotaxime. |
| Fluorescein | The excretion of Fluorescein can be decreased when combined with Cefotaxime. |
| Hydrocortisone | The excretion of Hydrocortisone can be decreased when combined with Cefotaxime. |
| Quinapril | The excretion of Quinapril can be decreased when combined with Cefotaxime. |
| Dinoprostone | The excretion of Dinoprostone can be decreased when combined with Cefotaxime. |
| Famotidine | The excretion of Famotidine can be decreased when combined with Cefotaxime. |
| Fexofenadine | The excretion of Fexofenadine can be decreased when combined with Cefotaxime. |
| Benzylpenicillin | The excretion of Benzylpenicillin can be decreased when combined with Cefotaxime. |
| Rosuvastatin | The excretion of Rosuvastatin can be decreased when combined with Cefotaxime. |
| Captopril | The excretion of Captopril can be decreased when combined with Cefotaxime. |
| Tazobactam | The excretion of Tazobactam can be decreased when combined with Cefotaxime. |
| Cyclic adenosine monophosphate | The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cefotaxime. |
| Cholic Acid | The excretion of Cholic Acid can be decreased when combined with Cefotaxime. |
| Glutaric Acid | The excretion of Glutaric Acid can be decreased when combined with Cefotaxime. |
| Oxalic Acid | The excretion of Oxalic Acid can be decreased when combined with Cefotaxime. |
| Taurocholic acid | The excretion of Taurocholic acid can be decreased when combined with Cefotaxime. |
| Ellagic acid | The excretion of Ellagic acid can be decreased when combined with Cefotaxime. |
| Avibactam | The excretion of Avibactam can be decreased when combined with Cefotaxime. |
| Eluxadoline | The excretion of Eluxadoline can be decreased when combined with Cefotaxime. |
| Silibinin | The excretion of Silibinin can be decreased when combined with Cefotaxime. |
| Relebactam | The excretion of Relebactam can be decreased when combined with Cefotaxime. |
| Oseltamivir | The excretion of Oseltamivir can be decreased when combined with Cefotaxime. |
| Conjugated estrogens | The excretion of Conjugated estrogens can be decreased when combined with Cefotaxime. |
| Piperacillin | The excretion of Piperacillin can be decreased when combined with Cefotaxime. |
| Trifluridine | The excretion of Trifluridine can be decreased when combined with Cefotaxime. |
| Allopurinol | The excretion of Allopurinol can be decreased when combined with Cefotaxime. |
| Cimetidine | The excretion of Cimetidine can be decreased when combined with Cefotaxime. |
| Methotrexate | The excretion of Methotrexate can be decreased when combined with Cefotaxime. |
| Cephalexin | The excretion of Cephalexin can be decreased when combined with Cefotaxime. |
| Valaciclovir | The excretion of Valaciclovir can be decreased when combined with Cefotaxime. |
| Levocarnitine | The excretion of Levocarnitine can be decreased when combined with Cefotaxime. |
| Tetracycline | The excretion of Tetracycline can be decreased when combined with Cefotaxime. |
| Estradiol | The excretion of Estradiol can be decreased when combined with Cefotaxime. |
| Acyclovir | The excretion of Acyclovir can be decreased when combined with Cefotaxime. |
| Cefaclor | The excretion of Cefaclor can be decreased when combined with Cefotaxime. |
| Ranitidine | The excretion of Ranitidine can be decreased when combined with Cefotaxime. |
| Bumetanide | The excretion of Bumetanide can be decreased when combined with Cefotaxime. |
| Sitagliptin | The excretion of Sitagliptin can be decreased when combined with Cefotaxime. |
| Ceftibuten | The excretion of Ceftibuten can be decreased when combined with Cefotaxime. |
| Doripenem | The excretion of Doripenem can be decreased when combined with Cefotaxime. |
| Saxagliptin | The excretion of Saxagliptin can be decreased when combined with Cefotaxime. |
| Baricitinib | The serum concentration of Baricitinib can be increased when it is combined with Cefotaxime. |
| Dexamethasone | The excretion of Dexamethasone can be decreased when combined with Cefotaxime. |
| Oxytetracycline | The excretion of Oxytetracycline can be decreased when combined with Cefotaxime. |
| Polythiazide | The excretion of Polythiazide can be decreased when combined with Cefotaxime. |
| Prednisolone phosphate | The excretion of Prednisolone phosphate can be decreased when combined with Cefotaxime. |
| Dexamethasone acetate | The excretion of Dexamethasone acetate can be decreased when combined with Cefotaxime. |
| Acamprosate | The excretion of Acamprosate can be decreased when combined with Cefotaxime. |
| Cyclosporine | The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefotaxime. |
| Icosapent | The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefotaxime. |
| Cefotiam | The excretion of Cefotiam can be decreased when combined with Cefotaxime. |
| Mesalazine | The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefotaxime. |
| Cefmenoxime | The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefotaxime. |
| Cefmetazole | The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefotaxime. |
| Indomethacin | The excretion of Indomethacin can be decreased when combined with Cefotaxime. |
| Triamterene | The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefotaxime. |
| Cefpiramide | The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefotaxime. |
| Loracarbef | The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefotaxime. |
| Cefalotin | The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefotaxime. |
| Nabumetone | The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefotaxime. |
| Ketorolac | The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefotaxime. |
| Tenoxicam | The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefotaxime. |
| Celecoxib | The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefotaxime. |
| Tolmetin | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Tolmetin. |
| Rofecoxib | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Rofecoxib. |
| Fenoprofen | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Fenoprofen. |
| Valdecoxib | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Valdecoxib. |
| Diclofenac | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Diclofenac. |
| Sulindac | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Sulindac. |
| Bacitracin | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Bacitracin. |
| Amphotericin B | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Amphotericin B. |
| Cephaloglycin | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cephaloglycin. |
| Adefovir dipivoxil | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Adefovir dipivoxil. |
| Pentamidine | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Pentamidine. |
| Mefenamic acid | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Mefenamic acid. |
| Naproxen | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Naproxen. |
| Sulfasalazine | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Sulfasalazine. |
| Phenylbutazone | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Phenylbutazone. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Cefotaxime is combined with Meloxicam. |
| Carprofen | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Carprofen. |
| Tacrolimus | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Tacrolimus. |
| Etacrynic acid | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Etacrynic acid. |
| Ceforanide | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Ceforanide. |
| Salicylic acid | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Salicylic acid. |
| Acetylsalicylic acid | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Acetylsalicylic acid. |
| Hydrochlorothiazide | The excretion of Hydrochlorothiazide can be decreased when combined with Cefotaxime. |
| Balsalazide | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Balsalazide. |
| Cefditoren | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefditoren. |