Peringatan Keamanan

Human overdoses of fosinopril have not been reported, but the most common manifestation of human fosinopril overdosage is likely to be hypotension. Oral doses of fosinopril at 2600 mg/kg in rats were associated with significant lethality. The most common adverse effects include dizzines, cough, fatigue, and headache.

Fosinopril

DB00492

small molecule approved

Deskripsi

Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.

Struktur Molekul 2D

Berat 563.672
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 12 hours
Volume Distribusi -
Klirens (Clearance) * 26 - 39 mL/min [healthy]

Absorpsi

Average absolute absorption is 36%. The primary site of absorption is the proximal small intestine (duodenum/jejunum). Food slows the rate of absorption with no effect on the extent of absorption.

Metabolisme

Since fosinoprilat is not biotransformed after intravenous administration, fosinopril, not fosinoprilat, appears to be the precursor for the glucuronide and p-hydroxy metabolites.

Rute Eliminasi

After oral administration of radiolabeled fosinopril, approximately half of the absorbed dose is excreted in the urine and the remainder is excreted in the feces.

Interaksi Makanan

5 Data
  • 1. Avoid hypertensive herbs (e.g. bayberry, blue cohosh, cayenne, ephedra, and licorice).
  • 2. Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
  • 3. Limit salt intake. Salt may attenuate the antihypertensive effect.
  • 4. Take separate from antacids. Take at least 2 hours before or after antacids. Taking this medication with antacids can reduce absorption.Taking this medication with antacids can reduce absorption.
  • 5. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1304 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Fosinopril is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Fosinopril is combined with Levodopa.
Risperidone Fosinopril may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Fosinopril.
Amifostine Fosinopril may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Fosinopril.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Fosinopril.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Fosinopril.
Obinutuzumab Fosinopril may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Fosinopril.
Rituximab Fosinopril may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Fosinopril.
Midodrine Midodrine may decrease the antihypertensive activities of Fosinopril.
Eletriptan Eletriptan may decrease the antihypertensive activities of Fosinopril.
Isoetharine Isoetharine may decrease the antihypertensive activities of Fosinopril.
Methysergide Methysergide may decrease the antihypertensive activities of Fosinopril.
Cabergoline Cabergoline may decrease the antihypertensive activities of Fosinopril.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Fosinopril.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Fosinopril.
Protriptyline Protriptyline may decrease the antihypertensive activities of Fosinopril.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Fosinopril.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Fosinopril.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Fosinopril.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Fosinopril.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Fosinopril.
Promazine Promazine may decrease the antihypertensive activities of Fosinopril.
Droperidol Droperidol may decrease the antihypertensive activities of Fosinopril.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Fosinopril.
Amoxapine Amoxapine may decrease the antihypertensive activities of Fosinopril.
Doxapram Doxapram may decrease the antihypertensive activities of Fosinopril.
Atropine Atropine may decrease the antihypertensive activities of Fosinopril.
Lisuride Lisuride may decrease the antihypertensive activities of Fosinopril.
Metaraminol Metaraminol may decrease the antihypertensive activities of Fosinopril.
Trazodone Trazodone may decrease the antihypertensive activities of Fosinopril.
Epinephrine Epinephrine may decrease the antihypertensive activities of Fosinopril.
Ergotamine Ergotamine may decrease the antihypertensive activities of Fosinopril.
Nicergoline Nicergoline may decrease the antihypertensive activities of Fosinopril.
Methoxamine Methoxamine may decrease the antihypertensive activities of Fosinopril.
Trimipramine Trimipramine may decrease the antihypertensive activities of Fosinopril.
Propiomazine Propiomazine may decrease the antihypertensive activities of Fosinopril.
Alfentanil Alfentanil may decrease the antihypertensive activities of Fosinopril.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Fosinopril.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Fosinopril.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Fosinopril.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Fosinopril.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Fosinopril.
Ritodrine Ritodrine may decrease the antihypertensive activities of Fosinopril.
Flupentixol Flupentixol may decrease the antihypertensive activities of Fosinopril.
Bitolterol Bitolterol may decrease the antihypertensive activities of Fosinopril.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Fosinopril.
Salmeterol Salmeterol may decrease the antihypertensive activities of Fosinopril.
Naratriptan Naratriptan may decrease the antihypertensive activities of Fosinopril.
Formoterol Formoterol may decrease the antihypertensive activities of Fosinopril.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Fosinopril.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Fosinopril.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Fosinopril.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Fosinopril.
Arbutamine Arbutamine may decrease the antihypertensive activities of Fosinopril.
Dutasteride Dutasteride may decrease the antihypertensive activities of Fosinopril.
Pergolide Pergolide may decrease the antihypertensive activities of Fosinopril.
Finasteride Finasteride may decrease the antihypertensive activities of Fosinopril.
Ergometrine Ergometrine may decrease the antihypertensive activities of Fosinopril.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Fosinopril.
Fenoterol Fenoterol may decrease the antihypertensive activities of Fosinopril.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Fosinopril.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Fosinopril.
Ephedrine Ephedrine may decrease the antihypertensive activities of Fosinopril.
Mephentermine Mephentermine may decrease the antihypertensive activities of Fosinopril.
Procaterol Procaterol may decrease the antihypertensive activities of Fosinopril.
Yohimbine Yohimbine may decrease the antihypertensive activities of Fosinopril.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Fosinopril.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Fosinopril.
Bambuterol Bambuterol may decrease the antihypertensive activities of Fosinopril.
MMDA MMDA may decrease the antihypertensive activities of Fosinopril.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Fosinopril.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Fosinopril.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Fosinopril.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Fosinopril.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Fosinopril.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Fosinopril.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Fosinopril.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Fosinopril.
Solifenacin Solifenacin may decrease the antihypertensive activities of Fosinopril.
Periciazine Periciazine may decrease the antihypertensive activities of Fosinopril.
Acepromazine Acepromazine may decrease the antihypertensive activities of Fosinopril.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Fosinopril.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Fosinopril.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Fosinopril.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Fosinopril.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Fosinopril.
Amineptine Amineptine may decrease the antihypertensive activities of Fosinopril.
Dronedarone Dronedarone may decrease the antihypertensive activities of Fosinopril.
Flibanserin Flibanserin may decrease the antihypertensive activities of Fosinopril.
Iloperidone Iloperidone may decrease the antihypertensive activities of Fosinopril.
Indacaterol Indacaterol may decrease the antihypertensive activities of Fosinopril.
Amibegron Amibegron may decrease the antihypertensive activities of Fosinopril.
Naluzotan Naluzotan may decrease the antihypertensive activities of Fosinopril.
Cariprazine Cariprazine may decrease the antihypertensive activities of Fosinopril.
Mianserin Mianserin may decrease the antihypertensive activities of Fosinopril.
Pizotifen Pizotifen may decrease the antihypertensive activities of Fosinopril.

Target Protein

Angiotensin-converting enzyme ACE

Referensi & Sumber

Synthesis reference: Sandra Gallego Pato, Antonio Palomo Coll, Francisco Palomo Nicolau, "Preparation of crystalline polymorphs of fosinopril sodium." U.S. Patent US20050010054, issued January 13, 2005.
Artikel (PubMed)
  • PMID: 11854791
    David D, Jallad N, Germino FW, Willett MS, de Silva J, Weidner SM, Mills DJ: A Comparison of the Cough Profile of Fosinopril and Enalapril in Hypertensive Patients with a History of ACE Inhibitor-Associated Cough. Am J Ther. 1995 Oct;2(10):806-813.
  • PMID: 11329095
    Sharma S, Deitchman D, Eni JS, Gelperin K, Ilgenfritz JP, Blumenthal M: The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther. 1999 Jul;6(4):181-9.

Contoh Produk & Brand

Produk: 162 • International brands: 3
Produk
  • Apo-fosinopril
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Apo-fosinopril
    Tablet • 20 mg • Oral • Canada • Generic • Approved
  • Ava-fosinopril
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Ava-fosinopril
    Tablet • 20 mg • Oral • Canada • Generic • Approved
  • Fosinopril
    Tablet • 10 mg • Oral • Canada • Approved
  • Fosinopril
    Tablet • 20 mg • Oral • Canada • Approved
  • FOSINOPRIL Na
    Tablet • 10 mg/1 • Oral • US • Generic • Approved
  • FOSINOPRIL Na
    Tablet • 20 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 162 produk.
International Brands
  • Acecor — SPA (Czech Republic)
  • Monopril
  • Staril — BMS (United Kingdom)

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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