Peringatan Keamanan

Unlike sulfonylureas or insulin, an overdose will not result in hypoglycemia. An overdose may result in transient increases in flatulence, diarrhea, and abdomi-nal discomfort. Because of the lack of extra-intestinal effects seen with miglitol, no serious systemic reactions are expected in the event of an overdose.

Miglitol

DB00491

small molecule approved

Deskripsi

Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body.

Miglitol should be taken at the start of a meal for maximal effect and the effect will depend on the amount of poly and oligosaccharides in the diet. Miglitol inhibits alpha-glucosidase, making less sugars available for digestion and reducing postprandial hyperglycemia.

Unlike other drugs of the same class, miglitol is not metabolized and the unmetabolized drug is excreted by the kidneys.

Struktur Molekul 2D

Berat 207.2243
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life of miglitol from plasma is approximately 2 hours.
Volume Distribusi * 0.18 L/kg
Klirens (Clearance) -

Absorpsi

Absorption of miglitol is saturable at high doses with 25 mg being completely absorbed while a 100-mg dose is only 50-70% absorbed. No evidence exists to show that systemic absorption of miglitol adds to its therapeutic effect.

Metabolisme

Miglitol is not metabolized in man or in any animal species studied.

Rute Eliminasi

Miglitol is not metabolized in man or in any animal species studied. It is eliminated by renal excretion as an unchanged drug.

Interaksi Makanan

1 Data
  • 1. Take with food. Take at the beginning of a meal.

Interaksi Obat

606 Data
Pegvisomant The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Miglitol.
Lipoic acid The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Miglitol.
Moxifloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Moxifloxacin.
Grepafloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Grepafloxacin.
Enoxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Enoxacin.
Pefloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Pefloxacin.
Ciprofloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Ciprofloxacin.
Trovafloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Trovafloxacin.
Nalidixic acid The therapeutic efficacy of Miglitol can be increased when used in combination with Nalidixic acid.
Rosoxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Rosoxacin.
Cinoxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Cinoxacin.
Lomefloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Lomefloxacin.
Gatifloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Gatifloxacin.
Norfloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Norfloxacin.
Levofloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Levofloxacin.
Gemifloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Gemifloxacin.
Ofloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Ofloxacin.
Sparfloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Sparfloxacin.
Temafloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Temafloxacin.
Fleroxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Fleroxacin.
Technetium Tc-99m ciprofloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Technetium Tc-99m ciprofloxacin.
Garenoxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Garenoxacin.
Nemonoxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Nemonoxacin.
Flumequine The therapeutic efficacy of Miglitol can be increased when used in combination with Flumequine.
Enrofloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Enrofloxacin.
Orbifloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Orbifloxacin.
Sarafloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Sarafloxacin.
Difloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Difloxacin.
Pazufloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Pazufloxacin.
Prulifloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Prulifloxacin.
Delafloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Delafloxacin.
Sitafloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Sitafloxacin.
Oxolinic acid The therapeutic efficacy of Miglitol can be increased when used in combination with Oxolinic acid.
Rufloxacin The therapeutic efficacy of Miglitol can be increased when used in combination with Rufloxacin.
Pipemidic acid The therapeutic efficacy of Miglitol can be increased when used in combination with Pipemidic acid.
Methyclothiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Methyclothiazide.
Chlorthalidone The therapeutic efficacy of Miglitol can be decreased when used in combination with Chlorthalidone.
Bendroflumethiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Bendroflumethiazide.
Metolazone The therapeutic efficacy of Miglitol can be decreased when used in combination with Metolazone.
Benzthiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Benzthiazide.
Hydroflumethiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Hydroflumethiazide.
Indapamide The therapeutic efficacy of Miglitol can be decreased when used in combination with Indapamide.
Chlorothiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Chlorothiazide.
Hydrochlorothiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Hydrochlorothiazide.
Trichlormethiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Trichlormethiazide.
Polythiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Polythiazide.
Quinethazone The therapeutic efficacy of Miglitol can be decreased when used in combination with Quinethazone.
Cyclopenthiazide The therapeutic efficacy of Miglitol can be decreased when used in combination with Cyclopenthiazide.
Epitizide The therapeutic efficacy of Miglitol can be decreased when used in combination with Epitizide.
Amitriptyline Amitriptyline may decrease the hypoglycemic activities of Miglitol.
Protriptyline Protriptyline may decrease the hypoglycemic activities of Miglitol.
Imipramine Imipramine may decrease the hypoglycemic activities of Miglitol.
Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Miglitol.
Amoxapine Amoxapine may decrease the hypoglycemic activities of Miglitol.
Trimipramine Trimipramine may decrease the hypoglycemic activities of Miglitol.
Doxepin Doxepin may decrease the hypoglycemic activities of Miglitol.
Desipramine Desipramine may decrease the hypoglycemic activities of Miglitol.
Clomipramine Clomipramine may decrease the hypoglycemic activities of Miglitol.
Amineptine Amineptine may decrease the hypoglycemic activities of Miglitol.
Dimetacrine Dimetacrine may decrease the hypoglycemic activities of Miglitol.
Butriptyline Butriptyline may decrease the hypoglycemic activities of Miglitol.
Dosulepin Dosulepin may decrease the hypoglycemic activities of Miglitol.
Tianeptine Tianeptine may decrease the hypoglycemic activities of Miglitol.
Oxaprotiline Oxaprotiline may decrease the hypoglycemic activities of Miglitol.
Opipramol Opipramol may decrease the hypoglycemic activities of Miglitol.
Amitriptylinoxide Amitriptylinoxide may decrease the hypoglycemic activities of Miglitol.
Dibenzepin Dibenzepin may decrease the hypoglycemic activities of Miglitol.
Quinupramine Quinupramine may decrease the hypoglycemic activities of Miglitol.
Melitracen Melitracen may decrease the hypoglycemic activities of Miglitol.
Lofepramine Lofepramine may decrease the hypoglycemic activities of Miglitol.
Iprindole Iprindole may decrease the hypoglycemic activities of Miglitol.
Imipramine oxide Imipramine oxide may decrease the hypoglycemic activities of Miglitol.
Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Miglitol.
Canagliflozin Canagliflozin may increase the hypoglycemic activities of Miglitol.
Leuprolide The therapeutic efficacy of Miglitol can be decreased when used in combination with Leuprolide.
Goserelin The therapeutic efficacy of Miglitol can be decreased when used in combination with Goserelin.
Nelfinavir The therapeutic efficacy of Miglitol can be decreased when used in combination with Nelfinavir.
Indinavir The therapeutic efficacy of Miglitol can be decreased when used in combination with Indinavir.
Ziprasidone The therapeutic efficacy of Miglitol can be decreased when used in combination with Ziprasidone.
Etonogestrel The therapeutic efficacy of Miglitol can be decreased when used in combination with Etonogestrel.
Desogestrel The therapeutic efficacy of Miglitol can be decreased when used in combination with Desogestrel.
Olanzapine The therapeutic efficacy of Miglitol can be decreased when used in combination with Olanzapine.
Megestrol acetate The therapeutic efficacy of Miglitol can be decreased when used in combination with Megestrol acetate.
Clozapine The therapeutic efficacy of Miglitol can be decreased when used in combination with Clozapine.
Levonorgestrel The therapeutic efficacy of Miglitol can be decreased when used in combination with Levonorgestrel.
Progesterone The therapeutic efficacy of Miglitol can be decreased when used in combination with Progesterone.
Chlorpromazine The therapeutic efficacy of Miglitol can be decreased when used in combination with Chlorpromazine.
Haloperidol The therapeutic efficacy of Miglitol can be decreased when used in combination with Haloperidol.
Ritonavir The therapeutic efficacy of Miglitol can be decreased when used in combination with Ritonavir.
Piperazine The therapeutic efficacy of Miglitol can be decreased when used in combination with Piperazine.
Medroxyprogesterone acetate The therapeutic efficacy of Miglitol can be decreased when used in combination with Medroxyprogesterone acetate.
Niacin The therapeutic efficacy of Miglitol can be decreased when used in combination with Niacin.
Epinephrine The therapeutic efficacy of Miglitol can be decreased when used in combination with Epinephrine.
Norethisterone The therapeutic efficacy of Miglitol can be decreased when used in combination with Norethisterone.
Risperidone The therapeutic efficacy of Miglitol can be decreased when used in combination with Risperidone.
Pentamidine The therapeutic efficacy of Miglitol can be decreased when used in combination with Pentamidine.
Ethynodiol diacetate The therapeutic efficacy of Miglitol can be decreased when used in combination with Ethynodiol diacetate.
Pseudoephedrine The therapeutic efficacy of Miglitol can be decreased when used in combination with Pseudoephedrine.
Tacrolimus The therapeutic efficacy of Miglitol can be decreased when used in combination with Tacrolimus.
Sirolimus The therapeutic efficacy of Miglitol can be decreased when used in combination with Sirolimus.

Target Protein

Lysosomal alpha-glucosidase GAA
Neutral alpha-glucosidase AB GANAB
Neutral alpha-glucosidase C GANC
Maltase-glucoamylase MGAM

Contoh Produk & Brand

Produk: 16 • International brands: 15
Produk
  • Glyset
    Tablet, film coated • 50 mg/1 • Oral • US • Approved
  • Glyset
    Tablet, film coated • 25 mg/1 • Oral • US • Approved
  • Glyset
    Tablet, film coated • 50 mg/1 • Oral • US • Approved
  • Glyset
    Tablet, film coated • 100 mg/1 • Oral • US • Approved
  • Miglitol
    Tablet, coated • 25 mg/1 • Oral • US • Generic • Approved
  • Miglitol
    Tablet, coated • 50 mg/1 • Oral • US • Generic • Approved
  • Miglitol
    Tablet, coated • 100 mg/1 • Oral • US • Generic • Approved
  • Miglitol
    Tablet, coated • 25 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 16 produk.
International Brands
  • Diaban — Chen Ho
  • Diamig — Micro DTF
  • Diaset — ACI
  • Diastabol — Sanofi-Aventis
  • Elitox — Ranbaxy
  • Euglitol — Abbott
  • Glycet — Pfizer
  • Laiping — Xinchang Pharmaceutical
  • Migbose — Standard
  • Miglit — Biocon

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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