Peringatan Keamanan

Adverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure.

Pefloxacin

DB00487

small molecule approved

Deskripsi

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

Struktur Molekul 2D

Berat 333.3574
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8.6 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed by the oral route.

Metabolisme

Hepatic. Primary metabolites are pefloxacin N-oxide and norfloxacin.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

935 Data
Didanosine Didanosine can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Probenecid Probenecid may decrease the excretion rate of Pefloxacin which could result in a higher serum level.
Quinapril Quinapril can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate Calcium acetate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran Iron Dextran can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Calcium can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate Lanthanum carbonate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric carboxymaltose Ferric carboxymaltose can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose Iron sucrose can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric pyrophosphate Ferric pyrophosphate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium citrate Calcium citrate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium gluconate Calcium gluconate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate Ferric sulfate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation Ferric cation can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetraferric tricitrate decahydrate Tetraferric tricitrate decahydrate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum III cation Lanthanum III cation can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium polycarbophil Calcium polycarbophil can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxyhydroxide Ferric oxyhydroxide can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Pefloxacin.
Nitrofurantoin The therapeutic efficacy of Pefloxacin can be decreased when used in combination with Nitrofurantoin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Pefloxacin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Pefloxacin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pefloxacin.
Insulin human The therapeutic efficacy of Insulin human can be increased when used in combination with Pefloxacin.
Insulin lispro The therapeutic efficacy of Insulin lispro can be increased when used in combination with Pefloxacin.
Insulin pork The therapeutic efficacy of Insulin pork can be increased when used in combination with Pefloxacin.
Troglitazone The therapeutic efficacy of Troglitazone can be increased when used in combination with Pefloxacin.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Pefloxacin.
Sulfisoxazole The therapeutic efficacy of Sulfisoxazole can be increased when used in combination with Pefloxacin.
Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Pefloxacin.
Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Pefloxacin.
Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Pefloxacin.
Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Pefloxacin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Pefloxacin.
Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Pefloxacin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Pefloxacin.
Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Pefloxacin.
Pentamidine The therapeutic efficacy of Pentamidine can be increased when used in combination with Pefloxacin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Pefloxacin.
Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Pefloxacin.
Phenformin The therapeutic efficacy of Phenformin can be increased when used in combination with Pefloxacin.
Sulfamethoxazole The therapeutic efficacy of Sulfamethoxazole can be increased when used in combination with Pefloxacin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Pefloxacin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Pefloxacin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Pefloxacin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Pefloxacin.
Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Pefloxacin.
Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Pefloxacin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Pefloxacin.
Mitiglinide The therapeutic efficacy of Mitiglinide can be increased when used in combination with Pefloxacin.
Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Pefloxacin.
Sunitinib The therapeutic efficacy of Sunitinib can be increased when used in combination with Pefloxacin.
Exenatide The therapeutic efficacy of Exenatide can be increased when used in combination with Pefloxacin.
Mecasermin The therapeutic efficacy of Mecasermin can be increased when used in combination with Pefloxacin.
Pramlintide The therapeutic efficacy of Pramlintide can be increased when used in combination with Pefloxacin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Pefloxacin.
Insulin aspart The therapeutic efficacy of Insulin aspart can be increased when used in combination with Pefloxacin.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Pefloxacin.
Glymidine The therapeutic efficacy of Glymidine can be increased when used in combination with Pefloxacin.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Pefloxacin.
Buformin The therapeutic efficacy of Buformin can be increased when used in combination with Pefloxacin.
Vildagliptin The therapeutic efficacy of Vildagliptin can be increased when used in combination with Pefloxacin.
Voglibose The therapeutic efficacy of Voglibose can be increased when used in combination with Pefloxacin.
NN344 The therapeutic efficacy of NN344 can be increased when used in combination with Pefloxacin.
AMG-222 The therapeutic efficacy of AMG-222 can be increased when used in combination with Pefloxacin.
Bisegliptin The therapeutic efficacy of Bisegliptin can be increased when used in combination with Pefloxacin.
Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Pefloxacin.
Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Pefloxacin.
Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Pefloxacin.
Liraglutide The therapeutic efficacy of Liraglutide can be increased when used in combination with Pefloxacin.
Gosogliptin The therapeutic efficacy of Gosogliptin can be increased when used in combination with Pefloxacin.
Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Pefloxacin.
Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Pefloxacin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Pefloxacin.
Benfluorex The therapeutic efficacy of Benfluorex can be increased when used in combination with Pefloxacin.
Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Pefloxacin.
Albiglutide The therapeutic efficacy of Albiglutide can be increased when used in combination with Pefloxacin.
Dulaglutide The therapeutic efficacy of Dulaglutide can be increased when used in combination with Pefloxacin.
Lobeglitazone The therapeutic efficacy of Lobeglitazone can be increased when used in combination with Pefloxacin.
Netoglitazone The therapeutic efficacy of Netoglitazone can be increased when used in combination with Pefloxacin.
Rivoglitazone The therapeutic efficacy of Rivoglitazone can be increased when used in combination with Pefloxacin.
Ciglitazone The therapeutic efficacy of Ciglitazone can be increased when used in combination with Pefloxacin.
Lixisenatide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Pefloxacin.
Insulin beef The therapeutic efficacy of Insulin beef can be increased when used in combination with Pefloxacin.
Insulin degludec The therapeutic efficacy of Insulin degludec can be increased when used in combination with Pefloxacin.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be increased when used in combination with Pefloxacin.
Insulin tregopil The therapeutic efficacy of Insulin tregopil can be increased when used in combination with Pefloxacin.
Ipragliflozin The therapeutic efficacy of Ipragliflozin can be increased when used in combination with Pefloxacin.
Dutogliptin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Pefloxacin.
Allicin The therapeutic efficacy of Allicin can be increased when used in combination with Pefloxacin.
Tofogliflozin The therapeutic efficacy of Tofogliflozin can be increased when used in combination with Pefloxacin.
Ertugliflozin The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Pefloxacin.
2,4-thiazolidinedione The therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Pefloxacin.
Teneligliptin The therapeutic efficacy of Teneligliptin can be increased when used in combination with Pefloxacin.
Omarigliptin The therapeutic efficacy of Omarigliptin can be increased when used in combination with Pefloxacin.
Carmegliptin The therapeutic efficacy of Carmegliptin can be increased when used in combination with Pefloxacin.
Gemigliptin The therapeutic efficacy of Gemigliptin can be increased when used in combination with Pefloxacin.

Target Protein

DNA topoisomerase 2-beta TOP2B
DNA topoisomerase 4 subunit A parC
DNA gyrase subunit A gyrA
DNA topoisomerase 2-alpha TOP2A
DNA topoisomerase 1 topA

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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