Peringatan Keamanan

Oral LD50 in rat is 3579 mg/kg. Symptoms of overexposure include irritation, rash, labored breathing, hives, itching, wheezing, nausea, chills, and fever.

Dicloxacillin

DB00485

small molecule approved investigational vet_approved

Deskripsi

One of the penicillins which is resistant to penicillinase.

Struktur Molekul 2D

Berat 470.326
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life for dicloxacillin is about 0.7 hour.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorption of the isoxazolyl penicillins after oral administration is rapid but incomplete: peak blood levels are achieved in 1-1.5 hours. Oral absorption of cloxacillin, dicloxacillin, oxacillin and nafcillin is delayed when the drugs are administered after meals.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Dicloxacillin sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Food decreases bioavailability.

Interaksi Obat

353 Data
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Dicloxacillin.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Dicloxacillin.
Methotrexate The excretion of Methotrexate can be decreased when combined with Dicloxacillin.
Probenecid The excretion of Dicloxacillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Penimepicycline.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Dicloxacillin.
Perampanel The metabolism of Perampanel can be increased when combined with Dicloxacillin.
Warfarin The metabolism of Warfarin can be increased when combined with Dicloxacillin.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Dicloxacillin.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Dicloxacillin.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Dicloxacillin.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Dicloxacillin.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Dicloxacillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Dicloxacillin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Dicloxacillin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dicloxacillin.
Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Dicloxacillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Dicloxacillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Dicloxacillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Dicloxacillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Dicloxacillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Dicloxacillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Dicloxacillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Dicloxacillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Dicloxacillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Dicloxacillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Dicloxacillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Dicloxacillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Dicloxacillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Dicloxacillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Dicloxacillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Dicloxacillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Dicloxacillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Dicloxacillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Dicloxacillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Dicloxacillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Dicloxacillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Dicloxacillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Dicloxacillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Dicloxacillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Dicloxacillin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Dicloxacillin.
Acemetacin Acemetacin may decrease the excretion rate of Dicloxacillin which could result in a higher serum level.
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Dicloxacillin.
Diethylstilbestrol The metabolism of Diethylstilbestrol can be increased when combined with Dicloxacillin.
Etonogestrel The metabolism of Etonogestrel can be increased when combined with Dicloxacillin.
Desogestrel The metabolism of Desogestrel can be increased when combined with Dicloxacillin.
Megestrol acetate The metabolism of Megestrol acetate can be increased when combined with Dicloxacillin.
Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Dicloxacillin.
Progesterone The metabolism of Progesterone can be increased when combined with Dicloxacillin.
Medroxyprogesterone acetate The metabolism of Medroxyprogesterone acetate can be increased when combined with Dicloxacillin.
Norethisterone The metabolism of Norethisterone can be increased when combined with Dicloxacillin.
Estradiol The metabolism of Estradiol can be increased when combined with Dicloxacillin.
Ethynodiol diacetate The metabolism of Ethynodiol diacetate can be increased when combined with Dicloxacillin.
Mifepristone The metabolism of Mifepristone can be increased when combined with Dicloxacillin.
Norgestimate The metabolism of Norgestimate can be increased when combined with Dicloxacillin.
Ethinylestradiol The metabolism of Ethinylestradiol can be increased when combined with Dicloxacillin.
Mestranol The metabolism of Mestranol can be increased when combined with Dicloxacillin.
Drospirenone The metabolism of Drospirenone can be increased when combined with Dicloxacillin.
Estrone sulfate The metabolism of Estrone sulfate can be increased when combined with Dicloxacillin.
Octylphenoxy polyethoxyethanol The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Dicloxacillin.
Cyproterone acetate The metabolism of Cyproterone acetate can be increased when combined with Dicloxacillin.
Trestolone The metabolism of Trestolone can be increased when combined with Dicloxacillin.
Norelgestromin The metabolism of Norelgestromin can be increased when combined with Dicloxacillin.
Gestodene The metabolism of Gestodene can be increased when combined with Dicloxacillin.
Hydroxyprogesterone caproate The metabolism of Hydroxyprogesterone caproate can be increased when combined with Dicloxacillin.
Dienogest The metabolism of Dienogest can be increased when combined with Dicloxacillin.
Norethynodrel The metabolism of Norethynodrel can be increased when combined with Dicloxacillin.
Norgestrel The metabolism of Norgestrel can be increased when combined with Dicloxacillin.
Cloprostenol The metabolism of Cloprostenol can be increased when combined with Dicloxacillin.
Gestrinone The metabolism of Gestrinone can be increased when combined with Dicloxacillin.
Nomegestrol The metabolism of Nomegestrol can be increased when combined with Dicloxacillin.
Lynestrenol The metabolism of Lynestrenol can be increased when combined with Dicloxacillin.
Gossypol The metabolism of Gossypol can be increased when combined with Dicloxacillin.
Ormeloxifene The metabolism of Ormeloxifene can be increased when combined with Dicloxacillin.
Chlormadinone The metabolism of Chlormadinone can be increased when combined with Dicloxacillin.
Norgestrienone The metabolism of Norgestrienone can be increased when combined with Dicloxacillin.
Quingestanol The metabolism of Quingestanol can be increased when combined with Dicloxacillin.
Demegestone The metabolism of Demegestone can be increased when combined with Dicloxacillin.
Etynodiol The metabolism of Etynodiol can be increased when combined with Dicloxacillin.
Testosterone enanthate The metabolism of Testosterone enanthate can be increased when combined with Dicloxacillin.
Estradiol benzoate The metabolism of Estradiol benzoate can be increased when combined with Dicloxacillin.
Estradiol cypionate The metabolism of Estradiol cypionate can be increased when combined with Dicloxacillin.
Estradiol valerate The metabolism of Estradiol valerate can be increased when combined with Dicloxacillin.
Nomegestrol acetate The metabolism of Nomegestrol acetate can be increased when combined with Dicloxacillin.
Norethindrone enanthate The metabolism of Norethindrone enanthate can be increased when combined with Dicloxacillin.
Ulipristal The metabolism of Ulipristal can be increased when combined with Dicloxacillin.

Target Protein

Penicillin-binding protein 3 pbpC
Penicillin-binding protein 1b pbp1b
Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 3 pbp3
Penicillin-binding protein 1A pbpA
Penicillin-binding protein 2B penA

Referensi & Sumber

Synthesis reference: Sallmann, A. and Pfister, R.; U.S.Patent 3,558,690; January 26,1971; assigned to Geigy Chemical Corporation. Sallmann, A. and Pfister, R.; US. Patent 3,652,762; March 28,1972; assigned to Ciba Geigy Corporation.

Contoh Produk & Brand

Produk: 40 • International brands: 20
Produk
  • Dicloxacillin Sodium
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Dicloxacillin Sodium
    Capsule • 500 mg/1 • Oral • US • Generic • Approved
  • Dicloxacillin Sodium
    Capsule • 500 mg/1 • Oral • US • Generic • Approved
  • Dicloxacillin Sodium
    Capsule • 500 mg/1 • Oral • US • Generic • Approved
  • Dicloxacillin Sodium
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Dicloxacillin Sodium
    Capsule • 500 mg/1 • Oral • US • Generic • Approved
  • Dicloxacillin Sodium
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Dicloxacillin Sodium
    Capsule • 500 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 40 produk.
International Brands
  • Amcidil — MacroPhar
  • Betaclox — Eskayef
  • Cloxagen — Genamerica
  • Dacocilin — CCPC
  • Damacir — Damacir
  • Dicillin — Sandoz
  • Diclex — Meiji
  • Diclocil — Bristol-Myers Squibb
  • Dicloplus — Icofarma
  • Dicloson — Unison

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul