Peringatan Keamanan

Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness

Chlorpromazine

DB00477

small molecule approved investigational vet_approved

Deskripsi

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

Struktur Molekul 2D

Berat 318.864
Wujud liquid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) ~ 30 hours
Volume Distribusi * 20 L/kg
Klirens (Clearance) -

Absorpsi

Readily absorbed from the GI tract. Bioavailability varies due to first-pass metabolism by the liver.

Metabolisme

Extensively metabolized in the liver and kidneys. It is extensively metabolized by cytochrome P450 isozymes CYP2D6 (major pathway), CYP1A2 and CYP3A4. Approximately 10 to 12 major metabolite have been identified. Hydroxylation at positions 3 and 7 of the phenothiazine nucleus and the N-dimethylaminopropyl side chain undergoes demethylation and is also metabolized to an N-oxide. In urine, 20% of chlopromazine and its metabolites are excreted unconjugated in the urine as unchanged drug, demonomethylchlorpromazine, dedimethylchlorpromazine, their sulfoxide metabolites, and chlorpromazine-N-oxide. The remaining 80% consists of conjugated metabolites, principally O-glucuronides and small amounts of ethereal sulfates of the mono- and dihydroxy-derivatives of chlorpromazine and their sulfoxide metabolites. The major metabolites are the monoglucuronide of N-dedimethylchlorpromazine and 7-hydroxychlorpromazine. Approximately 37% of the administered dose of chlorpromazine is excreted in urine.

Rute Eliminasi

Kidneys, ~ 37% excreted in urine

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

2510 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Chlorpromazine.
Desmopressin The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Desmopressin.
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Chlorpromazine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Chlorpromazine is combined with Levodopa.
Risperidone Chlorpromazine may increase the hypotensive activities of Risperidone.
Atropine Chlorpromazine may decrease the excretion rate of Atropine which could result in a higher serum level.
Glycochenodeoxycholic Acid Chlorpromazine may decrease the excretion rate of Glycochenodeoxycholic Acid which could result in a higher serum level.
Pravastatin Chlorpromazine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Diethylstilbestrol Chlorpromazine may decrease the excretion rate of Diethylstilbestrol which could result in a higher serum level.
Isradipine Chlorpromazine may decrease the excretion rate of Isradipine which could result in a higher serum level.
Flucloxacillin Chlorpromazine may decrease the excretion rate of Flucloxacillin which could result in a higher serum level.
Indomethacin Chlorpromazine may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Rosiglitazone Chlorpromazine may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Spironolactone Chlorpromazine may decrease the antihypertensive activities of Spironolactone.
Cerivastatin Chlorpromazine may decrease the excretion rate of Cerivastatin which could result in a higher serum level.
Diclofenac Chlorpromazine may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Losartan Chlorpromazine may decrease the antihypertensive activities of Losartan.
Fluorescein Chlorpromazine may decrease the excretion rate of Fluorescein which could result in a higher serum level.
Nitrofurantoin Chlorpromazine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Naproxen Chlorpromazine may decrease the excretion rate of Naproxen which could result in a higher serum level.
Disulfiram Chlorpromazine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Cefaclor Chlorpromazine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Tinidazole Chlorpromazine may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Repaglinide Chlorpromazine may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Telmisartan Chlorpromazine may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Ezetimibe Chlorpromazine may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Sulfamethoxazole Chlorpromazine may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
Fenofibrate Chlorpromazine may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Nitrendipine Chlorpromazine may decrease the excretion rate of Nitrendipine which could result in a higher serum level.
Rosuvastatin Chlorpromazine may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Sulfinpyrazone Chlorpromazine may decrease the excretion rate of Sulfinpyrazone which could result in a higher serum level.
Ofloxacin Chlorpromazine may decrease the excretion rate of Ofloxacin which could result in a higher serum level.
Taurocholic acid Chlorpromazine may decrease the excretion rate of Taurocholic acid which could result in a higher serum level.
Prasterone sulfate Chlorpromazine may decrease the excretion rate of Prasterone sulfate which could result in a higher serum level.
Indocyanine green acid form Chlorpromazine may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.
Benzbromarone Chlorpromazine may decrease the excretion rate of Benzbromarone which could result in a higher serum level.
Pilsicainide Chlorpromazine may decrease the excretion rate of Pilsicainide which could result in a higher serum level.
Dihydroergocristine Chlorpromazine may decrease the excretion rate of Dihydroergocristine which could result in a higher serum level.
Glycyrrhizic acid Chlorpromazine may decrease the excretion rate of Glycyrrhizic acid which could result in a higher serum level.
Loratadine Chlorpromazine may decrease the excretion rate of Loratadine which could result in a higher serum level.
Atorvastatin Chlorpromazine may decrease the excretion rate of Atorvastatin which could result in a higher serum level.
Belantamab mafodotin Chlorpromazine may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Phenytoin The metabolism of Chlorpromazine can be increased when combined with Phenytoin.
Fosphenytoin The metabolism of Chlorpromazine can be increased when combined with Fosphenytoin.
Deferasirox The serum concentration of Chlorpromazine can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Chlorpromazine can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Chlorpromazine can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Chlorpromazine can be decreased when it is combined with Teriflunomide.
Valsartan Chlorpromazine may decrease the antihypertensive activities of Valsartan.
Remikiren Chlorpromazine may decrease the antihypertensive activities of Remikiren.
Guanadrel Chlorpromazine may decrease the antihypertensive activities of Guanadrel.
Minoxidil Chlorpromazine may decrease the antihypertensive activities of Minoxidil.
Trandolapril Chlorpromazine may decrease the antihypertensive activities of Trandolapril.
Benazepril Chlorpromazine may decrease the antihypertensive activities of Benazepril.
Candoxatril Chlorpromazine may decrease the antihypertensive activities of Candoxatril.
Nitroglycerin Chlorpromazine may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Chlorpromazine may decrease the antihypertensive activities of Cryptenamine.
Eprosartan Chlorpromazine may decrease the antihypertensive activities of Eprosartan.
Quinapril Chlorpromazine may decrease the antihypertensive activities of Quinapril.
Omapatrilat Chlorpromazine may decrease the antihypertensive activities of Omapatrilat.
Deserpidine Chlorpromazine may decrease the antihypertensive activities of Deserpidine.
Rescinnamine Chlorpromazine may decrease the antihypertensive activities of Rescinnamine.
Saprisartan Chlorpromazine may decrease the antihypertensive activities of Saprisartan.
Spirapril Chlorpromazine may decrease the antihypertensive activities of Spirapril.
Diethylnorspermine Chlorpromazine may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Chlorpromazine may decrease the antihypertensive activities of Temocapril.
Rauwolfia serpentina root Chlorpromazine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Angiotensin 1-7 Chlorpromazine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Chlorpromazine may decrease the antihypertensive activities of Imidapril.
BQ-123 Chlorpromazine may decrease the antihypertensive activities of BQ-123.
Zofenopril Chlorpromazine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Chlorpromazine may decrease the antihypertensive activities of Guanoxan.
Delapril Chlorpromazine may decrease the antihypertensive activities of Delapril.
Vincamine Chlorpromazine may decrease the antihypertensive activities of Vincamine.
Linsidomine Chlorpromazine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Chlorpromazine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Chlorpromazine may decrease the antihypertensive activities of Tolonidine.
Endralazine Chlorpromazine may decrease the antihypertensive activities of Endralazine.
Cadralazine Chlorpromazine may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Chlorpromazine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Chlorpromazine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Chlorpromazine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Chlorpromazine may decrease the antihypertensive activities of Guanoclor.
Tocopherylquinone Chlorpromazine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Chlorpromazine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Chlorpromazine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Chlorpromazine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Chlorpromazine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Chlorpromazine may decrease the antihypertensive activities of Quinaprilat.
Pinacidil Chlorpromazine may decrease the antihypertensive activities of Pinacidil.
Riociguat Chlorpromazine may decrease the antihypertensive activities of Riociguat.
Aliskiren Chlorpromazine may decrease the antihypertensive activities of Aliskiren.
Enalapril Chlorpromazine may decrease the antihypertensive activities of Enalapril.
Candesartan cilexetil Chlorpromazine may decrease the antihypertensive activities of Candesartan cilexetil.
Captopril Chlorpromazine may decrease the antihypertensive activities of Captopril.
Cilazapril Chlorpromazine may decrease the antihypertensive activities of Cilazapril.
Ambrisentan Chlorpromazine may decrease the antihypertensive activities of Ambrisentan.
Selexipag Chlorpromazine may decrease the antihypertensive activities of Selexipag.
Candesartan Chlorpromazine may decrease the antihypertensive activities of Candesartan.
Ramipril Chlorpromazine may decrease the antihypertensive activities of Ramipril.

Target Protein

D(2) dopamine receptor DRD2
D(1A) dopamine receptor DRD1
5-hydroxytryptamine receptor 1A HTR1A
5-hydroxytryptamine receptor 2A HTR2A
Alpha-1A adrenergic receptor ADRA1A
Alpha-1B adrenergic receptor ADRA1B
Histamine H1 receptor HRH1
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2
D(1) dopamine receptor DRD1
D(3) dopamine receptor DRD3
D(4) dopamine receptor DRD4
D(1B) dopamine receptor DRD5
5-hydroxytryptamine receptor 2C HTR2C
5-hydroxytryptamine 2 receptor HTR2A
Alpha-1 adrenergic receptors ADRA1A
Alpha-2 adrenergic receptors ADRA2A
Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M3 CHRM3
Sphingomyelin phosphodiesterase SMPD1
alpha1-acid glycoprotein ORM1
5-hydroxytryptamine receptor 6 HTR6
5-hydroxytryptamine receptor 7 HTR7
Histamine H4 receptor HRH4
Calmodulin CALM1

Referensi & Sumber

Synthesis reference: Charpentier, P.; U S . Patent 2,645,640; July 14, 1953; assigned to Societe des Usines Chimiques Rhone-Poulenc, France.
Artikel (PubMed)
  • PMID: 12747876
    Leucht S, Wahlbeck K, Hamann J, Kissling W: New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis. Lancet. 2003 May 10;361(9369):1581-9.

Contoh Produk & Brand

Produk: 260 • International brands: 7
Produk
  • Apo Chlorpromazine
    Tablet • 55.7 mg • Oral • Canada • Generic • Approved
  • Apo Chlorpromazine
    Tablet • 111.4 mg • Oral • Canada • Generic • Approved
  • Apo Chlorpromazine
    Tablet • 27.9 mg • Oral • Canada • Generic • Approved
  • Chlorprom Tab 100mg
    Tablet • 111.6 mg / tab • Oral • Canada • Approved
  • Chlorprom Tab 25mg
    Tablet • 27.9 mg / tab • Oral • Canada • Approved
  • Chlorprom Tab 50mg
    Tablet • 55.8 mg / tab • Oral • Canada • Approved
  • Chlorpromanyl 20 Syr
    Solution / drops • 22.2 mg / mL • Oral • Canada • Approved
  • Chlorpromanyl 40 Drops Syr 44.5mg/ml
    Syrup • 44.5 mg / mL • Oral • Canada • Approved
Menampilkan 8 dari 260 produk.
International Brands
  • Aminazine
  • Chlorderazin
  • Chloropromazine
  • Chlorpromados
  • Chlorpromanyl — Technilab (Canada)
  • Contomin
  • Largactil — Specia

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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