Peringatan Keamanan

LD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).

Chlordiazepoxide

DB00475

small molecule approved illicit investigational

Deskripsi

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.

Struktur Molekul 2D

Berat 299.755
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 24-48 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic.

Rute Eliminasi

Chlordiazepoxide is excreted in the urine, with 1% to 2% unchanged and 3% to 6% as conjugate.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

713 Data
Buprenorphine Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Hydrocodone Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Magnesium sulfate The therapeutic efficacy of Chlordiazepoxide can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Chlordiazepoxide may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Mirtazapine Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Orphenadrine Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Pramipexole Chlordiazepoxide may increase the sedative activities of Pramipexole.
Ropinirole Chlordiazepoxide may increase the sedative activities of Ropinirole.
Rotigotine Chlordiazepoxide may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Chlordiazepoxide.
Suvorexant Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Thalidomide Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clozapine.
Methadone Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Sodium oxybate Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Chlordiazepoxide can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Chlordiazepoxide can be increased when used in combination with Yohimbine.
Ethanol Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Zimelidine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Chlordiazepoxide.
Propiomazine The risk or severity of CNS depression can be increased when Chlordiazepoxide is combined with Propiomazine.
Zopiclone The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zopiclone.
Caffeine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Caffeine.
Dyphylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Mercaptopurine.
Oxtriphylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 7,9-Dimethylguanine.
Xanthine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Xanthine.
7-Deazaguanine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 7-Deazaguanine.
Guanine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Guanine.
9-Methylguanine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 9-Methylguanine.
Peldesine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Peldesine.
Hypoxanthine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Hypoxanthine.
9-Deazaguanine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 9-Deazaguanine.
Propentofylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Propentofylline.
Valomaciclovir The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Valomaciclovir.
3-isobutyl-1-methyl-7H-xanthine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
Uric acid The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Uric acid.
Doxofylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Doxofylline.
6-O-benzylguanine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 6-O-benzylguanine.
Lisofylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Lisofylline.
Lobucavir The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Lobucavir.
Cafedrine The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Cafedrine.
Theodrenaline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Theodrenaline.
Bamifylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Bamifylline.
Proxyphylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Proxyphylline.
Acefylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Acefylline.
Etamiphylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Etamiphylline.
Pentifylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Pentifylline.
Bufylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Bufylline.
Bromotheophylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Bromotheophylline.
Furafylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Furafylline.
8-chlorotheophylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with 8-chlorotheophylline.
PCS-499 The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with PCS-499.
Theophylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Theophylline.
Aminophylline The therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Aminophylline.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Chlordiazepoxide.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Chlordiazepoxide.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Chlordiazepoxide.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Chlordiazepoxide.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Chlordiazepoxide.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Chlordiazepoxide.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Chlordiazepoxide.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Chlordiazepoxide.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Chlordiazepoxide.

Target Protein

Translocator protein TSPO
GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Synthesis reference: Sternbach, L.H.; US. Patent 2,893,992; July 7,1959; assigned to Hoffmann-LaRoche, Inc.
Artikel (PubMed)

Contoh Produk & Brand

Produk: 164 • International brands: 12
Produk
  • Chlorax
    Capsule • - • Oral • Canada • Approved
  • Chlordiazepoxide
    Capsule, gelatin coated • 25 mg/1 • Oral • US • Generic • Approved
  • Chlordiazepoxide
    Capsule • 25 mg/1 • Oral • US • Generic • Approved
  • Chlordiazepoxide
    Capsule • 5 mg • Oral • Canada • Approved
  • Chlordiazepoxide
    Capsule • 10 mg • Oral • Canada • Approved
  • Chlordiazepoxide
    Capsule • 25 mg • Oral • Canada • Approved
  • Chlordiazepoxide and Amitriptyline HCl
    Tablet • - • Oral • US • Generic • Approved
  • Chlordiazepoxide and Amitriptyline HCl
    Tablet • - • Oral • US • Generic • Approved
Menampilkan 8 dari 164 produk.
International Brands
  • Angirex
  • Elenium — Polfa Tarchomin
  • Helogaphen
  • Klopoxid — Nycomed
  • Libritabs
  • Multum
  • Napoton
  • Radepur — AWD
  • Risolid — Actavis
  • Silibrin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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