Overdose of drug and/or light in the treated eye may result in nonperfusion of normal retinal vessels with the possibility of severe decrease in vision that could be permanent. An overdose of drug will also result in the prolongation of the period during which the patient remains photosensitive to bright light.
Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: CL-315555 and CL-315585. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Porfimer sodium | Verteporfin may increase the photosensitizing activities of Porfimer sodium. |
| Riboflavin | Riboflavin may increase the photosensitizing activities of Verteporfin. |
| Methoxsalen | Methoxsalen may increase the photosensitizing activities of Verteporfin. |
| Carprofen | Carprofen may increase the photosensitizing activities of Verteporfin. |
| Aminolevulinic acid | Aminolevulinic acid may increase the photosensitizing activities of Verteporfin. |
| Tiaprofenic acid | Tiaprofenic acid may increase the photosensitizing activities of Verteporfin. |
| Protoporphyrin | Protoporphyrin may increase the photosensitizing activities of Verteporfin. |
| Trioxsalen | Trioxsalen may increase the photosensitizing activities of Verteporfin. |
| Acetophenone | Acetophenone may increase the photosensitizing activities of Verteporfin. |
| Motexafin lutetium | Motexafin lutetium may increase the photosensitizing activities of Verteporfin. |
| Motexafin gadolinium | Motexafin gadolinium may increase the photosensitizing activities of Verteporfin. |
| Hexaminolevulinate | Hexaminolevulinate may increase the photosensitizing activities of Verteporfin. |
| Rostaporfin | Rostaporfin may increase the photosensitizing activities of Verteporfin. |
| Cyamemazine | Cyamemazine may increase the photosensitizing activities of Verteporfin. |
| Temoporfin | Temoporfin may increase the photosensitizing activities of Verteporfin. |
| Talaporfin | Talaporfin may increase the photosensitizing activities of Verteporfin. |
| Bergapten | Bergapten may increase the photosensitizing activities of Verteporfin. |
| Dihematoporphyrin ether | Dihematoporphyrin ether may increase the photosensitizing activities of Verteporfin. |
| Titanium dioxide | Titanium dioxide may increase the photosensitizing activities of Verteporfin. |
| Clofazimine | Clofazimine may increase the photosensitizing activities of Verteporfin. |
| Vemurafenib | Vemurafenib may increase the photosensitizing activities of Verteporfin. |
| Metoprolol | Metoprolol may increase the photosensitizing activities of Verteporfin. |
| Methotrimeprazine | Methotrimeprazine may increase the photosensitizing activities of Verteporfin. |
| Nilotinib | Nilotinib may increase the photosensitizing activities of Verteporfin. |
| Methylene blue | Methylene blue may increase the photosensitizing activities of Verteporfin. |
| Dabrafenib | Dabrafenib may increase the photosensitizing activities of Verteporfin. |
| Febuxostat | Febuxostat may increase the photosensitizing activities of Verteporfin. |
| Fosdenopterin | Fosdenopterin may increase the photosensitizing activities of Verteporfin. |
| Cyproheptadine | Cyproheptadine may increase the photosensitizing activities of Verteporfin. |
| Hemoporfin | Hemoporfin may increase the photosensitizing activities of Verteporfin. |
| Tretinoin | The risk or severity of adverse effects can be increased when Tretinoin is combined with Verteporfin. |
| Levofloxacin | Levofloxacin may increase the photosensitizing activities of Verteporfin. |
| Padeliporfin | Verteporfin may increase the photosensitizing activities of Padeliporfin. |
| Lamotrigine | Lamotrigine may increase the photosensitizing activities of Verteporfin. |
| Oxcarbazepine | Oxcarbazepine may increase the photosensitizing activities of Verteporfin. |
| Dasatinib | Dasatinib may increase the photosensitizing activities of Verteporfin. |
| Celecoxib | Celecoxib may increase the photosensitizing activities of Verteporfin. |
| Itraconazole | Itraconazole may increase the photosensitizing activities of Verteporfin. |
| Losartan | Losartan may increase the photosensitizing activities of Verteporfin. |