Peringatan Keamanan

TDLO, LD50: Oral TDLO (human): 285 ?g/kg; Oral TDLO (woman): 10 ?g/kg MSDS.

Oral LD50 (rat): 1950 mg/kg; Intraperitoneal LD50 (rat): 102 mg/kg MSDS.

Overdose information

Accidental ingestion of at least 50 mg of prazosin by a two-year-old child led to severe drowsiness with depressed reflexes. There was no fall in blood pressure, and the child recovered without complication FDA label.

Use in pregnancy

There are no adequate and well-controlled studies determining the safety of prazosin use during pregnancy. It is considered a pregnancy category C drug. Prazosin should be used during pregnancy only in cases where the benefit outweighs the possible risk to the mother and fetus FDA label. In specific cases where blood pressure control was emergent during pregnancy, prazosin has been used and no effects on the fetus or neonate were reported FDA label.

Use in nursing

This drug is found excreted in small concentrations in human milk. This drug should be used with caution when used during nursing FDA label.

Prazosin

DB00457

small molecule approved

Deskripsi

Prazosin is a drug used to treat hypertension. Prazosin is marketed by Pfizer and was initially approved by the FDA in 1988.L5828 It belongs to the class of drugs known as alpha-1 antagonists.

Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares.A176618, A176621, A176624

Struktur Molekul 2D

Berat 383.4011
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The plasma half-life is about 2-3 hours [FDA label].
Volume Distribusi About 0.6 L/kg [A176657].
Klirens (Clearance) In patients with congestive heart failure, the clearance of this drug is decreased. Impairment of renal function does not have relevant effects on elimination [A176630].

Absorpsi

After administration of an oral dose, peak plasma concentrations are attained at approximately 3 hours FDA label. There is a linear association between the prazosin dose given and plasma concentration at steady state A176657.

Metabolisme

In animals, prazosin hydrochloride is heavily metabolized. This occurs through liver demethylation and conjugation FDA label. Some studies in humans or human cells in vitro show similar prazosin metabolism A176627, A176663.

Rute Eliminasi

This drug is mainly excreted in the bile and the feces FDA label.

Interaksi Makanan

3 Data
  • 1. Avoid alcohol.
  • 2. Avoid natural licorice.
  • 3. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

866 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Prazosin is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Prazosin is combined with Levodopa.
Risperidone Prazosin may increase the hypotensive activities of Risperidone.
Amifostine Prazosin may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Prazosin.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Prazosin.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Prazosin.
Obinutuzumab Prazosin may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Prazosin.
Rituximab Prazosin may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Prazosin.
Methysergide Methysergide may decrease the antihypertensive activities of Prazosin.
Atomoxetine Atomoxetine may decrease the antihypertensive activities of Prazosin.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Prazosin.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Prazosin.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Prazosin.
Doxapram Doxapram may decrease the antihypertensive activities of Prazosin.
Atropine Atropine may decrease the antihypertensive activities of Prazosin.
Lisuride Lisuride may decrease the antihypertensive activities of Prazosin.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Prazosin.
Almotriptan Almotriptan may decrease the antihypertensive activities of Prazosin.
Naratriptan Naratriptan may decrease the antihypertensive activities of Prazosin.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Prazosin.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Prazosin.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Prazosin.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Prazosin.
Dutasteride Dutasteride may decrease the antihypertensive activities of Prazosin.
Finasteride Finasteride may decrease the antihypertensive activities of Prazosin.
Solifenacin Solifenacin may decrease the antihypertensive activities of Prazosin.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Prazosin.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Prazosin.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Prazosin.
Amineptine Amineptine may decrease the antihypertensive activities of Prazosin.
Naluzotan Naluzotan may decrease the antihypertensive activities of Prazosin.
Cariprazine Cariprazine may decrease the antihypertensive activities of Prazosin.
Mianserin Mianserin may decrease the antihypertensive activities of Prazosin.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Prazosin.
Vilazodone Vilazodone may decrease the antihypertensive activities of Prazosin.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Prazosin.
Saralasin Saralasin may decrease the antihypertensive activities of Prazosin.
Cinitapride Cinitapride may decrease the antihypertensive activities of Prazosin.
Tyramine Tyramine may decrease the antihypertensive activities of Prazosin.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Prazosin.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Prazosin.
Butriptyline Butriptyline may decrease the antihypertensive activities of Prazosin.
Vortioxetine Vortioxetine may decrease the antihypertensive activities of Prazosin.
Dosulepin Dosulepin may decrease the antihypertensive activities of Prazosin.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Prazosin.
Tianeptine Tianeptine may decrease the antihypertensive activities of Prazosin.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Prazosin.
Dihydroergocornine Dihydroergocornine may decrease the antihypertensive activities of Prazosin.
Atipamezole Atipamezole may decrease the antihypertensive activities of Prazosin.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Prazosin.
Piclozotan Piclozotan may decrease the antihypertensive activities of Prazosin.
Siponimod Siponimod may decrease the antihypertensive activities of Prazosin.
Idazoxan Idazoxan may decrease the antihypertensive activities of Prazosin.
Opipramol Opipramol may decrease the antihypertensive activities of Prazosin.
Tramazoline Tramazoline may decrease the antihypertensive activities of Prazosin.
Amitriptylinoxide Amitriptylinoxide may decrease the antihypertensive activities of Prazosin.
Dibenzepin Dibenzepin may decrease the antihypertensive activities of Prazosin.
Quinupramine Quinupramine may decrease the antihypertensive activities of Prazosin.
Trichloroethylene Trichloroethylene may decrease the antihypertensive activities of Prazosin.
Fenozolone Fenozolone may decrease the antihypertensive activities of Prazosin.
Dihydroergocristine Dihydroergocristine may decrease the antihypertensive activities of Prazosin.
Melitracen Melitracen may decrease the antihypertensive activities of Prazosin.
Dihydroergocryptine Dihydroergocryptine may decrease the antihypertensive activities of Prazosin.
Terguride Terguride may decrease the antihypertensive activities of Prazosin.
Lofepramine Lofepramine may decrease the antihypertensive activities of Prazosin.
Xenon Xenon may decrease the antihypertensive activities of Prazosin.
Iprindole Iprindole may decrease the antihypertensive activities of Prazosin.
Buflomedil Buflomedil may decrease the antihypertensive activities of Prazosin.
Metergoline Metergoline may decrease the antihypertensive activities of Prazosin.
Imipramine oxide Imipramine oxide may decrease the antihypertensive activities of Prazosin.
Mefenorex Mefenorex may decrease the antihypertensive activities of Prazosin.
5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Prazosin.
Quinoline Yellow WS Quinoline Yellow WS may decrease the antihypertensive activities of Prazosin.
Solriamfetol Solriamfetol may decrease the antihypertensive activities of Prazosin.
Sufentanil Sufentanil may decrease the antihypertensive activities of Prazosin.
Isoflurane Isoflurane may decrease the antihypertensive activities of Prazosin.
Remifentanil Remifentanil may decrease the antihypertensive activities of Prazosin.
Halothane Halothane may decrease the antihypertensive activities of Prazosin.
Desflurane Desflurane may decrease the antihypertensive activities of Prazosin.
Sevoflurane Sevoflurane may decrease the antihypertensive activities of Prazosin.
Rotigotine Rotigotine may decrease the antihypertensive activities of Prazosin.
Eletriptan Eletriptan may decrease the antihypertensive activities of Prazosin.
Cabergoline Cabergoline may decrease the antihypertensive activities of Prazosin.
Protriptyline Protriptyline may decrease the antihypertensive activities of Prazosin.
Buspirone Buspirone may decrease the antihypertensive activities of Prazosin.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Prazosin.
Alfentanil Alfentanil may decrease the antihypertensive activities of Prazosin.
Fentanyl Fentanyl may decrease the antihypertensive activities of Prazosin.
Propofol Propofol may decrease the antihypertensive activities of Prazosin.
Acetylsalicylic acid Acetylsalicylic acid may decrease the antihypertensive activities of Prazosin.
Clomipramine Clomipramine may decrease the antihypertensive activities of Prazosin.
Yohimbine Yohimbine may decrease the antihypertensive activities of Prazosin.
Flibanserin Flibanserin may decrease the antihypertensive activities of Prazosin.
Diethyl ether Diethyl ether may decrease the antihypertensive activities of Prazosin.
Selpercatinib Selpercatinib may decrease the antihypertensive activities of Prazosin.
Naxitamab Naxitamab may decrease the antihypertensive activities of Prazosin.
Bupropion The excretion of Prazosin can be decreased when combined with Bupropion.

Target Protein

Alpha-1A adrenergic receptor ADRA1A
Alpha-1B adrenergic receptor ADRA1B
Alpha-1D adrenergic receptor ADRA1D
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2
Alpha-2A adrenergic receptor ADRA2A
Alpha-2B adrenergic receptor ADRA2B
Alpha-1 adrenergic receptors ADRA1A

Referensi & Sumber

Synthesis reference: Stig O. E. Lindholm, "A process for the preparation of anhydrous, stable, crystalline delta-form of prazosin hydrochloride." U.S. Patent US4873330, issued 0000.
Artikel (PubMed)
  • PMID: 17444339
    Bawaskar HS, Bawaskar PH: Utility of scorpion antivenin vs prazosin in the management of severe Mesobuthus tamulus (Indian red scorpion) envenoming at rural setting. J Assoc Physicians India. 2007 Jan;55:14-21.
  • PMID: 12461301
    Cushman WC, Ford CE, Cutler JA, Margolis KL, Davis BR, Grimm RH, Black HR, Hamilton BP, Holland J, Nwachuku C, Papademetriou V, Probstfield J, Wright JT Jr, Alderman MH, Weiss RJ, Piller L, Bettencourt J, Walsh SM: Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich). 2002 Nov-Dec;4(6):393-404.
  • PMID: 12827214
    Hiraoka Y, Taniguchi T, Tanaka T, Okada K, Kanamaru H, Muramatsu I: Pharmacological characterization of unique prazosin-binding sites in human kidney. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):49-56. Epub 2003 Jun 25.
  • PMID: 22883741
    Kung S, Espinel Z, Lapid MI: Treatment of nightmares with prazosin: a systematic review. Mayo Clin Proc. 2012 Sep;87(9):890-900. doi: 10.1016/j.mayocp.2012.05.015. Epub 2012 Aug 9.
  • PMID: 22943034
    Hudson SM, Whiteside TE, Lorenz RA, Wargo KA: Prazosin for the treatment of nightmares related to posttraumatic stress disorder: a review of the literature. Prim Care Companion CNS Disord. 2012;14(2). pii: 11r01222. doi: 10.4088/PCC.11r01222. Epub 2012 Mar 22.
  • PMID: 24490030
    Koola MM, Varghese SP, Fawcett JA: High-dose prazosin for the treatment of post-traumatic stress disorder. Ther Adv Psychopharmacol. 2014 Feb;4(1):43-7. doi: 10.1177/2045125313500982.
  • PMID: 6994981
    Jaillon P: Clinical pharmacokinetics of prazosin. Clin Pharmacokinet. 1980 Jul-Aug;5(4):365-76. doi: 10.2165/00003088-198005040-00004.
  • PMID: 6303744
    Stanaszek WF, Kellerman D, Brogden RN, Romankiewicz JA: Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure. Drugs. 1983 Apr;25(4):339-84. doi: 10.2165/00003495-198325040-00002.
Menampilkan 8 dari 15 artikel.

Contoh Produk & Brand

Produk: 193 • International brands: 4
Produk
  • Alti-prazosin-tab 1mg
    Tablet • 1 mg • Oral • Canada • Generic • Approved
  • Alti-prazosin-tab 2mg
    Tablet • 2 mg • Oral • Canada • Generic • Approved
  • Alti-prazosin-tab 5mg
    Tablet • 5 mg • Oral • Canada • Generic • Approved
  • Apo-prazo Tab 1mg
    Tablet • 1 mg • Oral • Canada • Generic • Approved
  • Apo-prazo Tab 2mg
    Tablet • 2 mg • Oral • Canada • Generic • Approved
  • Apo-prazo Tab 5mg
    Tablet • 5 mg • Oral • Canada • Generic • Approved
  • Minipress
    Capsule • 1 mg/1 • Oral • US • Approved
  • Minipress
    Capsule • 2 mg/1 • Oral • US • Approved
Menampilkan 8 dari 193 produk.
International Brands
  • Hypovase
  • Minipress Xl — Pfizer
  • Pressin
  • Vasoflex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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