Peringatan Keamanan

Rat intravenous LD50 is 4000 mg/kg.

Cefalotin

DB00456

small molecule approved investigational vet_approved

Deskripsi

Cefalotin is a cephalosporin antibiotic.

Struktur Molekul 2D

Berat 396.438
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 30 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

906 Data
Probenecid The serum concentration of Cefalotin can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefalotin.
Tenofovir disoproxil Cefalotin may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefalotin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefalotin may increase the nephrotoxic activities of Tenofovir.
Succinic acid The excretion of Succinic acid can be decreased when combined with Cefalotin.
Citrulline The excretion of Citrulline can be decreased when combined with Cefalotin.
Pravastatin The excretion of Pravastatin can be decreased when combined with Cefalotin.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Cefalotin.
Zidovudine The excretion of Zidovudine can be decreased when combined with Cefalotin.
Cefdinir The excretion of Cefdinir can be decreased when combined with Cefalotin.
Leucovorin The excretion of Leucovorin can be decreased when combined with Cefalotin.
Fluorescein The excretion of Fluorescein can be decreased when combined with Cefalotin.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Cefalotin.
Quinapril The excretion of Quinapril can be decreased when combined with Cefalotin.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Cefalotin.
Famotidine The excretion of Famotidine can be decreased when combined with Cefalotin.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Cefalotin.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Cefalotin.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Cefalotin.
Captopril The excretion of Captopril can be decreased when combined with Cefalotin.
Tazobactam The excretion of Tazobactam can be decreased when combined with Cefalotin.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cefalotin.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Cefalotin.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Cefalotin.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Cefalotin.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Cefalotin.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Cefalotin.
Avibactam The excretion of Avibactam can be decreased when combined with Cefalotin.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Cefalotin.
Silibinin The excretion of Silibinin can be decreased when combined with Cefalotin.
Relebactam The excretion of Relebactam can be decreased when combined with Cefalotin.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Cefalotin.
Conjugated estrogens The excretion of Conjugated estrogens can be decreased when combined with Cefalotin.
Piperacillin The excretion of Piperacillin can be decreased when combined with Cefalotin.
Trifluridine The excretion of Trifluridine can be decreased when combined with Cefalotin.
Allopurinol The excretion of Allopurinol can be decreased when combined with Cefalotin.
Cimetidine The excretion of Cimetidine can be decreased when combined with Cefalotin.
Methotrexate The excretion of Methotrexate can be decreased when combined with Cefalotin.
Cephalexin The excretion of Cephalexin can be decreased when combined with Cefalotin.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Cefalotin.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Cefalotin.
Tetracycline The excretion of Tetracycline can be decreased when combined with Cefalotin.
Estradiol The excretion of Estradiol can be decreased when combined with Cefalotin.
Acyclovir The excretion of Acyclovir can be decreased when combined with Cefalotin.
Cefaclor The excretion of Cefaclor can be decreased when combined with Cefalotin.
Ranitidine The excretion of Ranitidine can be decreased when combined with Cefalotin.
Bumetanide The excretion of Bumetanide can be decreased when combined with Cefalotin.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Cefalotin.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Cefalotin.
Doripenem The excretion of Doripenem can be decreased when combined with Cefalotin.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Cefalotin.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Cefalotin.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Cefalotin.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Cefalotin.
Polythiazide The excretion of Polythiazide can be decreased when combined with Cefalotin.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Cefalotin.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Cefalotin.
Acamprosate The excretion of Acamprosate can be decreased when combined with Cefalotin.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefalotin.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefalotin.
Cefotiam The excretion of Cefotiam can be decreased when combined with Cefalotin.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefalotin.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefalotin.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefalotin.
Indomethacin The excretion of Indomethacin can be decreased when combined with Cefalotin.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefalotin.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefalotin.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefalotin.
Nabumetone The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Nabumetone.
Ketorolac The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Ketorolac.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Tenoxicam.
Celecoxib The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Celecoxib.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefotaxime.
Tolmetin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Tolmetin.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Rofecoxib.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Fenoprofen.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Valdecoxib.
Diclofenac The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Diclofenac.
Sulindac The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Sulindac.
Bacitracin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Bacitracin.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Amphotericin B.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cephaloglycin.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Adefovir dipivoxil.
Pentamidine The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Pentamidine.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Mefenamic acid.
Naproxen The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Naproxen.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Sulfasalazine.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Phenylbutazone.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefalotin is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Carprofen.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Tacrolimus.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Etacrynic acid.
Ceforanide The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Ceforanide.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Salicylic acid.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Acetylsalicylic acid.
Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Cefalotin.
Balsalazide The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Balsalazide.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefditoren.

Target Protein

D-alanyl-D-alanine carboxypeptidase
Penicillin-binding protein 1A pbpA
Penicillin-binding protein 1b pbp1b
Penicillin-binding protein 3 pbp3
Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 2B penA
Penicillin-binding protein 1A pbpA
Beta-lactamase ampC

Referensi & Sumber

Synthesis reference: Michael D. Cise, Michael L. Roy, "Method of preparing a rapidly dissolving powder of crystalline cephalothin sodium for parenteral administration." U.S. Patent US4132848, issued December, 1977.

Contoh Produk & Brand

Produk: 4 • International brands: 3
Produk
  • Ceporacin
    Powder, for solution • 1 g / vial • Intramuscular; Intravenous • Canada • Approved
  • Keflin Add-vantage Inj 1gm/vial
    Liquid • 1 g / vial • Intravenous • Canada • Approved
  • Keflin Neutral Inj 1gm
    Powder, for solution • 1 g / vial • Intramuscular; Intravenous • Canada • Approved
  • Keflin Neutral Inj 2gm/vial
    Powder, for solution • 2 g / vial • Intramuscular; Intravenous • Canada • Approved
International Brands
  • Cefalotina fabra
  • Coaxin
  • Keflin — Lilly

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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