Peringatan Keamanan

Oral LD50 in rat is 183 mg/kg.

Dipivefrin

DB00449

small molecule approved

Deskripsi

Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).

Struktur Molekul 2D

Berat 351.4373
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed following occular administration.

Metabolisme

Dipivefrin is converted to epinephrine inside the human eye by enzyme hydrolysis.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

56 Data
Mianserin The therapeutic efficacy of Dipivefrin can be decreased when used in combination with Mianserin.
Formoterol Dipivefrin may increase the sympathomimetic activities of Formoterol.
Oxymetazoline Dipivefrin may increase the hypertensive and vasoconstricting activities of Oxymetazoline.
Vasopressin Vasopressin may increase the hypertensive activities of Dipivefrin.
Methacholine Dipivefrin may decrease effectiveness of Methacholine as a diagnostic agent.
Methyclothiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Methyclothiazide.
Bendroflumethiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Bendroflumethiazide.
Benzthiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Benzthiazide.
Cyclothiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Cyclothiazide.
Hydroflumethiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Hydroflumethiazide.
Chlorothiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Chlorothiazide.
Hydrochlorothiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Hydrochlorothiazide.
Trichlormethiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Trichlormethiazide.
Polythiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Polythiazide.
Mebutizide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Mebutizide.
Cyclopenthiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Cyclopenthiazide.
Buthiazide The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Buthiazide.
Caffeine The risk or severity of hypokalemia can be increased when Caffeine is combined with Dipivefrin.
Theophylline The risk or severity of hypokalemia can be increased when Theophylline is combined with Dipivefrin.
Dyphylline The risk or severity of hypokalemia can be increased when Dyphylline is combined with Dipivefrin.
Pentoxifylline The risk or severity of hypokalemia can be increased when Pentoxifylline is combined with Dipivefrin.
Mercaptopurine The risk or severity of hypokalemia can be increased when Mercaptopurine is combined with Dipivefrin.
Aminophylline The risk or severity of hypokalemia can be increased when Aminophylline is combined with Dipivefrin.
Oxtriphylline The risk or severity of hypokalemia can be increased when Oxtriphylline is combined with Dipivefrin.
Theobromine The risk or severity of hypokalemia can be increased when Theobromine is combined with Dipivefrin.
Fenethylline The risk or severity of hypokalemia can be increased when Fenethylline is combined with Dipivefrin.
8-azaguanine The risk or severity of hypokalemia can be increased when 8-azaguanine is combined with Dipivefrin.
7,9-Dimethylguanine The risk or severity of hypokalemia can be increased when 7,9-Dimethylguanine is combined with Dipivefrin.
Xanthine The risk or severity of hypokalemia can be increased when Xanthine is combined with Dipivefrin.
7-Deazaguanine The risk or severity of hypokalemia can be increased when 7-Deazaguanine is combined with Dipivefrin.
Guanine The risk or severity of hypokalemia can be increased when Guanine is combined with Dipivefrin.
9-Methylguanine The risk or severity of hypokalemia can be increased when 9-Methylguanine is combined with Dipivefrin.
Peldesine The risk or severity of hypokalemia can be increased when Peldesine is combined with Dipivefrin.
Hypoxanthine The risk or severity of hypokalemia can be increased when Hypoxanthine is combined with Dipivefrin.
9-Deazaguanine The risk or severity of hypokalemia can be increased when 9-Deazaguanine is combined with Dipivefrin.
Propentofylline The risk or severity of hypokalemia can be increased when Propentofylline is combined with Dipivefrin.
Valomaciclovir The risk or severity of hypokalemia can be increased when Valomaciclovir is combined with Dipivefrin.
3-isobutyl-1-methyl-7H-xanthine The risk or severity of hypokalemia can be increased when 3-isobutyl-1-methyl-7H-xanthine is combined with Dipivefrin.
Uric acid The risk or severity of hypokalemia can be increased when Uric acid is combined with Dipivefrin.
Doxofylline The risk or severity of hypokalemia can be increased when Doxofylline is combined with Dipivefrin.
6-O-benzylguanine The risk or severity of hypokalemia can be increased when 6-O-benzylguanine is combined with Dipivefrin.
Lisofylline The risk or severity of hypokalemia can be increased when Lisofylline is combined with Dipivefrin.
Lobucavir The risk or severity of hypokalemia can be increased when Lobucavir is combined with Dipivefrin.
Cafedrine The risk or severity of hypokalemia can be increased when Cafedrine is combined with Dipivefrin.
Theodrenaline The risk or severity of hypokalemia can be increased when Theodrenaline is combined with Dipivefrin.
Bamifylline The risk or severity of hypokalemia can be increased when Bamifylline is combined with Dipivefrin.
Proxyphylline The risk or severity of hypokalemia can be increased when Proxyphylline is combined with Dipivefrin.
Acefylline The risk or severity of hypokalemia can be increased when Acefylline is combined with Dipivefrin.
Etamiphylline The risk or severity of hypokalemia can be increased when Etamiphylline is combined with Dipivefrin.
Pentifylline The risk or severity of hypokalemia can be increased when Pentifylline is combined with Dipivefrin.
Bufylline The risk or severity of hypokalemia can be increased when Bufylline is combined with Dipivefrin.
Bromotheophylline The risk or severity of hypokalemia can be increased when Bromotheophylline is combined with Dipivefrin.
Furafylline The risk or severity of hypokalemia can be increased when Furafylline is combined with Dipivefrin.
8-chlorotheophylline The risk or severity of hypokalemia can be increased when 8-chlorotheophylline is combined with Dipivefrin.
PCS-499 The risk or severity of hypokalemia can be increased when PCS-499 is combined with Dipivefrin.
Lomifylline The risk or severity of hypokalemia can be increased when Lomifylline is combined with Dipivefrin.

Target Protein

Beta-1 adrenergic receptor ADRB1
Alpha-1A adrenergic receptor ADRA1A
Alpha-2A adrenergic receptor ADRA2A
Beta-2 adrenergic receptor ADRB2
Cholinesterase BCHE
Acetylcholinesterase ACHE

Referensi & Sumber

Synthesis reference: Hussain, A. and Truelove, J.E.; U.S. Patents 3,809.714; May 7,1974; and 3,839,584; October 1, 1974; both assigned to Inter Rx Research Corp. Henschler, D., Wagner, J. and Hampel, H.; US. Patent 4,085,270; April 18,1978; assigned to Chemisch-Pharmazeutische Fabrik Adolf Klinge & Co. (W. Germany).

Contoh Produk & Brand

Produk: 10 • International brands: 6
Produk
  • Apo-dipivefrin
    Liquid • 0.1 % • Ophthalmic • Canada • Generic • Approved
  • Dipivefrin Hydrochloride
    Solution / drops • 1 mg/1mL • Ophthalmic • US • Generic • Approved
  • Dipivefrin Hydrochloride
    Solution • 1 mg/1mL • Ophthalmic • US • Generic • Approved
  • Dipivefrin-liq Oph 0.1%
    Liquid • .1 % • Ophthalmic • Canada • Approved
  • Dpe Ophthalmic Solution - 0.1%
    Solution / drops • .1 % • Ophthalmic; Topical • Canada • Approved
  • PMS-dipivefrin
    Solution / drops • 0.1 % • Ophthalmic • Canada • Generic • Approved
  • Probeta - Liq Oph
    Liquid • - • Ophthalmic • Canada • Approved
  • Propine
    Solution / drops • 1 mg/1mL • Ophthalmic • US • Approved
Menampilkan 8 dari 10 produk.
International Brands
  • AKPro — Akorn
  • D Epifrin — Allergan
  • Diopine — Allergan
  • Pivalephrine — Santen Pharmaceutical
  • Pro-Epinephrine
  • Thilodrin — Alcon

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul