Teniposide

DB00444

small molecule approved

Deskripsi

Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.

Struktur Molekul 2D

Berat 656.654
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 5 hours
Volume Distribusi -
Klirens (Clearance) * 10.3 mL/min/m2

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

From 4% to 12% of a dose is excreted in urine as parent drug. Fecal excretion of radioactivity within 72 hours after dosing accounted for 0% to 10% of the dose.

Interaksi Makanan

2 Data
  • 1. Exercise caution with grapefruit products. Teniposide is a CYP3A4 substrate, and grapefruit inhibits CYP3A4 metabolism, coadministration may increase the serum concentrations of teniposide.
  • 2. Exercise caution with St. John's Wort. Teniposide is a CYP3A4 substrate, and St. John's Wort induces CYP3A4 metabolism, coadministration may reduce the serum concentrations of teniposide.

Interaksi Obat

1297 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Teniposide.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Teniposide.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Teniposide.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Teniposide.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Teniposide.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Teniposide.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Teniposide.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Teniposide.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Teniposide.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Teniposide.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Teniposide.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Teniposide.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Teniposide.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Teniposide.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Teniposide.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Teniposide.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Teniposide.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Teniposide.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Teniposide.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Teniposide.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Teniposide.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Teniposide.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Teniposide.
Cladribine Teniposide may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Teniposide.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Teniposide.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Teniposide.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Teniposide.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Teniposide.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Teniposide.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Teniposide.
Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Teniposide.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Teniposide.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Teniposide.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Teniposide.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Teniposide.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Teniposide is combined with Epirubicin.
Lenalidomide The risk or severity of adverse effects can be increased when Teniposide is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Teniposide is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Teniposide is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Teniposide is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Teniposide is combined with Oxaliplatin.
Fluorouracil The risk or severity of adverse effects can be increased when Teniposide is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Teniposide is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Teniposide is combined with Pentostatin.
Linezolid The risk or severity of adverse effects can be increased when Teniposide is combined with Linezolid.
Clofarabine The risk or severity of adverse effects can be increased when Teniposide is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Teniposide is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Teniposide is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Teniposide is combined with Fludrocortisone.
Sulfasalazine The risk or severity of adverse effects can be increased when Teniposide is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Teniposide is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Teniposide is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Teniposide is combined with Penicillamine.
Mechlorethamine The risk or severity of adverse effects can be increased when Teniposide is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Teniposide is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Teniposide is combined with Carboplatin.
Dactinomycin The risk or severity of adverse effects can be increased when Teniposide is combined with Dactinomycin.
Azathioprine The risk or severity of adverse effects can be increased when Teniposide is combined with Azathioprine.
Hydroxyurea The risk or severity of adverse effects can be increased when Teniposide is combined with Hydroxyurea.
Mycophenolic acid The risk or severity of adverse effects can be increased when Teniposide is combined with Mycophenolic acid.
Mercaptopurine The risk or severity of adverse effects can be increased when Teniposide is combined with Mercaptopurine.
Thalidomide The metabolism of Teniposide can be increased when combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Teniposide is combined with Melphalan.
Fludarabine The risk or severity of adverse effects can be increased when Teniposide is combined with Fludarabine.
Flucytosine The risk or severity of adverse effects can be increased when Teniposide is combined with Flucytosine.
Procarbazine The risk or severity of adverse effects can be increased when Teniposide is combined with Procarbazine.
Arsenic trioxide The risk or severity of adverse effects can be increased when Teniposide is combined with Arsenic trioxide.
Idarubicin The risk or severity of adverse effects can be increased when Teniposide is combined with Idarubicin.
Estramustine The risk or severity of adverse effects can be increased when Teniposide is combined with Estramustine.
Lomustine The risk or severity of adverse effects can be increased when Teniposide is combined with Lomustine.
Eculizumab The risk or severity of adverse effects can be increased when Teniposide is combined with Eculizumab.
Decitabine The risk or severity of adverse effects can be increased when Teniposide is combined with Decitabine.
Nelarabine The risk or severity of adverse effects can be increased when Teniposide is combined with Nelarabine.
Ciclesonide The risk or severity of adverse effects can be increased when Teniposide is combined with Ciclesonide.
Stepronin The risk or severity of adverse effects can be increased when Teniposide is combined with Stepronin.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Teniposide is combined with Hydroxychloroquine.
Castanospermine The risk or severity of adverse effects can be increased when Teniposide is combined with Castanospermine.
Vorinostat The risk or severity of adverse effects can be increased when Teniposide is combined with Vorinostat.
2-Methoxyethanol The risk or severity of adverse effects can be increased when Teniposide is combined with 2-Methoxyethanol.
Brequinar The risk or severity of adverse effects can be increased when Teniposide is combined with Brequinar.
Aldosterone The risk or severity of adverse effects can be increased when Teniposide is combined with Aldosterone.
Pirfenidone The risk or severity of adverse effects can be increased when Teniposide is combined with Pirfenidone.
Interferon alfa The risk or severity of adverse effects can be increased when Teniposide is combined with Interferon alfa.
Glatiramer The risk or severity of adverse effects can be increased when Teniposide is combined with Glatiramer.
Briakinumab The risk or severity of adverse effects can be increased when Teniposide is combined with Briakinumab.
Human interferon omega-1 The risk or severity of adverse effects can be increased when Teniposide is combined with Human interferon omega-1.
Mepolizumab The risk or severity of adverse effects can be increased when Teniposide is combined with Mepolizumab.
Abetimus The risk or severity of adverse effects can be increased when Teniposide is combined with Abetimus.
Belatacept The risk or severity of adverse effects can be increased when Teniposide is combined with Belatacept.
Bendamustine The risk or severity of adverse effects can be increased when Teniposide is combined with Bendamustine.
Pralatrexate The risk or severity of adverse effects can be increased when Teniposide is combined with Pralatrexate.
Wortmannin The risk or severity of adverse effects can be increased when Teniposide is combined with Wortmannin.
Eribulin The risk or severity of adverse effects can be increased when Teniposide is combined with Eribulin.
Belimumab The risk or severity of adverse effects can be increased when Teniposide is combined with Belimumab.
Teriflunomide The risk or severity of adverse effects can be increased when Teniposide is combined with Teriflunomide.
Carfilzomib The risk or severity of adverse effects can be increased when Teniposide is combined with Carfilzomib.
Dimethyl fumarate The risk or severity of adverse effects can be increased when Teniposide is combined with Dimethyl fumarate.
Obinutuzumab The risk or severity of adverse effects can be increased when Teniposide is combined with Obinutuzumab.

Target Protein

DNA topoisomerase 2-alpha TOP2A
DNA topoisomerase 2-beta TOP2B

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 3 • International brands: 1
Produk
  • Teniposide
    Injection, solution • 10 mg/1mL • Intravenous • US • Approved
  • Vumon
    Injection, solution • 10 mg/1mL • Intravenous • US • Approved
  • Vumon
    Liquid • 10 mg / mL • Intravenous • Canada • Approved
International Brands
  • Bang Lai — Double-Crane

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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