Peringatan Keamanan

Healthy subjects who received single entecavir doses up to 40 mg or multiple doses up to 20 mg/day for up to 14 days had no increase in or unexpected adverse events. If overdose occurs, the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.

Entecavir

DB00442

small molecule approved investigational

Deskripsi

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).

Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.

Struktur Molekul 2D

Berat 277.2792
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) After reaching peak concentration, entecavir plasma concentrations decreased in a bi-exponential manner with a terminal elimination half-life of approximately 128-149 hours. The phosphorylated metabolite has a half-life of 15 hours.
Volume Distribusi -
Klirens (Clearance) * renal cl=383.2 +/- 101.8 mL/min [Unimpaired renal function] * renal cl=197.9 +/- 78.1 mL/min [Mild impaired renal function] * renal cl=135.6 +/- 31.6 mL/min [Moderate impaired renal function] * renal cl=40.3 +/- 10.1 mL/min [severe impaired renal function] * apparent oral cl=588.1 +/- 153.7 mL/min [Unimpaired renal function] * apparent oral cl=309.2 +/- 62.6 mL/min [Mild impaired renal function] * apparent oral cl=226.3 +/- 60.1 mL/min [Moderate impaired renal function] * apparent oral cl=100.6 +/- 29.1 mL/min [severe impaired renal function] * apparent oral cl=50.6 +/- 16.5 mL/min [severe impaired renal function amnaged with Hemodialysis] * apparent oral cl=35.7 +/- 19.6 mL/min [severe impaired renal function amnaged with CAPD]

Absorpsi

Absorption Following oral administration in healthy subjects, entecavir peak plasma concentrations occurred between 0.5 and 1.5 hours. In healthy subjects, the bioavailability of the tablet is 100% relative to the oral solution.

Metabolisme

Entecavir is not a substrate, inhibitor, or inducer of the cytochrome P450 (CYP450) enzyme system. Entecavir is efficiently phosphorylated to the active triphosphate form.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Take 2 hours before or 2 hours after a meal.

Interaksi Obat

328 Data
Deferasirox The serum concentration of Entecavir can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Entecavir can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Entecavir can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Entecavir can be decreased when it is combined with Teriflunomide.
Ribavirin Ribavirin may increase the hepatotoxic activities of Entecavir.
Abiraterone The serum concentration of Entecavir can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Entecavir can be increased when combined with Cyproterone acetate.
Ganciclovir The risk or severity of cytopenia can be increased when Ganciclovir is combined with Entecavir.
Valganciclovir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Entecavir.
Carbamazepine The metabolism of Entecavir can be increased when combined with Carbamazepine.
Primidone The metabolism of Entecavir can be increased when combined with Primidone.
Rifampin The metabolism of Entecavir can be increased when combined with Rifampicin.
Albendazole The metabolism of Entecavir can be increased when combined with Albendazole.
Caffeine The metabolism of Entecavir can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Entecavir can be decreased when combined with Moxifloxacin.
Lidocaine The metabolism of Entecavir can be decreased when combined with Lidocaine.
Mexiletine The metabolism of Entecavir can be decreased when combined with Mexiletine.
Imipramine The metabolism of Entecavir can be decreased when combined with Imipramine.
Alosetron The metabolism of Entecavir can be decreased when combined with Alosetron.
Ketoconazole The metabolism of Entecavir can be decreased when combined with Ketoconazole.
Gatifloxacin The metabolism of Entecavir can be decreased when combined with Gatifloxacin.
Simeprevir The metabolism of Entecavir can be decreased when combined with Simeprevir.
Lobeglitazone The metabolism of Entecavir can be decreased when combined with Lobeglitazone.
Pazufloxacin The metabolism of Entecavir can be decreased when combined with Pazufloxacin.
Osilodrostat The metabolism of Entecavir can be decreased when combined with Osilodrostat.
Osimertinib The serum concentration of Entecavir can be decreased when it is combined with Osimertinib.
Vemurafenib The serum concentration of Entecavir can be increased when it is combined with Vemurafenib.
Citalopram The metabolism of Entecavir can be decreased when combined with Citalopram.
Cimetidine The metabolism of Entecavir can be decreased when combined with Cimetidine.
Trovafloxacin The metabolism of Entecavir can be decreased when combined with Trovafloxacin.
Viloxazine The metabolism of Entecavir can be decreased when combined with Viloxazine.
Pipemidic acid The metabolism of Entecavir can be decreased when combined with Pipemidic acid.
Nevirapine The metabolism of Entecavir can be decreased when combined with Nevirapine.
Famotidine The metabolism of Entecavir can be decreased when combined with Famotidine.
Ethambutol The metabolism of Entecavir can be decreased when combined with Ethambutol.
Belinostat The metabolism of Entecavir can be increased when combined with Belinostat.
Insulin pork The metabolism of Entecavir can be increased when combined with Insulin pork.
Phenylephrine The metabolism of Entecavir can be increased when combined with Phenylephrine.
Nafcillin The metabolism of Entecavir can be increased when combined with Nafcillin.
Fosphenytoin The metabolism of Entecavir can be increased when combined with Fosphenytoin.
NN344 The metabolism of Entecavir can be increased when combined with NN344.
Dovitinib The metabolism of Entecavir can be increased when combined with Dovitinib.
Armodafinil The metabolism of Entecavir can be increased when combined with Armodafinil.
beta-Naphthoflavone The metabolism of Entecavir can be increased when combined with beta-Naphthoflavone.
Insulin peglispro The metabolism of Entecavir can be increased when combined with Insulin peglispro.
Insulin tregopil The metabolism of Entecavir can be increased when combined with Insulin tregopil.
Pitolisant The metabolism of Entecavir can be increased when combined with Pitolisant.
Insulin beef The metabolism of Entecavir can be increased when combined with Insulin beef.
Ritonavir The metabolism of Entecavir can be increased when combined with Ritonavir.
Somatotropin The metabolism of Entecavir can be increased when combined with Somatotropin.
Somapacitan The metabolism of Entecavir can be increased when combined with Somapacitan.
Peginterferon alfa-2a The metabolism of Entecavir can be decreased when combined with Peginterferon alfa-2a.
Interferon alfa-n1 The metabolism of Entecavir can be decreased when combined with Interferon alfa-n1.
Interferon alfa-n3 The metabolism of Entecavir can be decreased when combined with Interferon alfa-n3.
Interferon gamma-1b The metabolism of Entecavir can be decreased when combined with Interferon gamma-1b.
Interferon alfa-2a The metabolism of Entecavir can be decreased when combined with Interferon alfa-2a.
Interferon beta-1a The metabolism of Entecavir can be decreased when combined with Interferon beta-1a.
Interferon beta-1b The metabolism of Entecavir can be decreased when combined with Interferon beta-1b.
Interferon alfacon-1 The metabolism of Entecavir can be decreased when combined with Interferon alfacon-1.
Interferon alfa-2b The metabolism of Entecavir can be decreased when combined with Interferon alfa-2b.
Ticlopidine The metabolism of Entecavir can be decreased when combined with Ticlopidine.
Valproic acid The metabolism of Entecavir can be decreased when combined with Valproic acid.
Promazine The metabolism of Entecavir can be decreased when combined with Promazine.
Pefloxacin The metabolism of Entecavir can be decreased when combined with Pefloxacin.
Methoxsalen The metabolism of Entecavir can be decreased when combined with Methoxsalen.
Efavirenz The metabolism of Entecavir can be decreased when combined with Efavirenz.
Dexmedetomidine The metabolism of Entecavir can be decreased when combined with Dexmedetomidine.
Thiabendazole The metabolism of Entecavir can be decreased when combined with Thiabendazole.
Methimazole The metabolism of Entecavir can be decreased when combined with Methimazole.
Nalidixic acid The metabolism of Entecavir can be decreased when combined with Nalidixic acid.
Rosoxacin The metabolism of Entecavir can be decreased when combined with Rosoxacin.
Cinoxacin The metabolism of Entecavir can be decreased when combined with Cinoxacin.
Isoniazid The metabolism of Entecavir can be decreased when combined with Isoniazid.
Norfloxacin The metabolism of Entecavir can be decreased when combined with Norfloxacin.
Tegaserod The metabolism of Entecavir can be decreased when combined with Tegaserod.
Gemifloxacin The metabolism of Entecavir can be decreased when combined with Gemifloxacin.
Orphenadrine The metabolism of Entecavir can be decreased when combined with Orphenadrine.
Propafenone The metabolism of Entecavir can be decreased when combined with Propafenone.
Gemfibrozil The metabolism of Entecavir can be decreased when combined with Gemfibrozil.
Mibefradil The metabolism of Entecavir can be decreased when combined with Mibefradil.
Estrone sulfate The metabolism of Entecavir can be decreased when combined with Estrone sulfate.
Albinterferon Alfa-2B The metabolism of Entecavir can be decreased when combined with Albinterferon Alfa-2B.
Obeticholic acid The metabolism of Entecavir can be decreased when combined with Obeticholic acid.
Garenoxacin The metabolism of Entecavir can be decreased when combined with Garenoxacin.
Nemonoxacin The metabolism of Entecavir can be decreased when combined with Nemonoxacin.
Niclosamide The metabolism of Entecavir can be decreased when combined with Niclosamide.
Flumequine The metabolism of Entecavir can be decreased when combined with Flumequine.
Stiripentol The metabolism of Entecavir can be increased when combined with Stiripentol.
Enrofloxacin The metabolism of Entecavir can be decreased when combined with Enrofloxacin.
Orbifloxacin The metabolism of Entecavir can be decreased when combined with Orbifloxacin.
Sarafloxacin The metabolism of Entecavir can be decreased when combined with Sarafloxacin.
Difloxacin The metabolism of Entecavir can be decreased when combined with Difloxacin.
Diacerein The metabolism of Entecavir can be decreased when combined with Diacerein.
Triclabendazole The metabolism of Entecavir can be decreased when combined with Triclabendazole.
Dihydralazine The metabolism of Entecavir can be decreased when combined with Dihydralazine.
Rhein The metabolism of Entecavir can be decreased when combined with Rhein.
Sitafloxacin The metabolism of Entecavir can be decreased when combined with Sitafloxacin.
Enasidenib The metabolism of Entecavir can be decreased when combined with Enasidenib.
Estradiol acetate The metabolism of Entecavir can be decreased when combined with Estradiol acetate.
Ropeginterferon alfa-2b The metabolism of Entecavir can be decreased when combined with Ropeginterferon alfa-2b.

Target Protein

DNA

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 91 • International brands: 4
Produk
  • Accel-entecavir
    Tablet • 0.5 mg • Oral • Canada • Generic • Approved
  • Apo-entecavir
    Tablet • 0.5 mg • Oral • Canada • Generic • Approved
  • Auro-entecavir
    Tablet • 0.5 mg • Oral • Canada • Generic • Approved
  • Baraclude
    Tablet, film coated • 0.5 mg/1 • Oral • US • Approved
  • Baraclude
    Tablet, film coated • 1.0 mg/1 • Oral • US • Approved
  • Baraclude
    Solution • 0.05 mg/1mL • Oral • US • Approved
  • Baraclude
    Tablet • 0.5 mg • Oral • Canada • Approved
  • Baraclude
    Tablet, film coated • 0.5 mg • Oral • EU • Approved
Menampilkan 8 dari 91 produk.
International Brands
  • Barcavir — Incepta
  • Caavirel — PMP
  • Entaliv — Dr. Reddy's Laboratories
  • Teviral — ACI

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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