Bendroflumethiazide

DB00436

small molecule approved

Deskripsi

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)

Struktur Molekul 2D

Berat 421.415
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8.5 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed relatively rapidly after oral administration

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with food. Food increases bioavailability.

Interaksi Obat

1706 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Bendroflumethiazide is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Bendroflumethiazide is combined with Levodopa.
Risperidone Bendroflumethiazide may increase the hypotensive activities of Risperidone.
Ceritinib Bendroflumethiazide may increase the bradycardic activities of Ceritinib.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Bendroflumethiazide.
Alfuzosin Alfuzosin may increase the hypotensive activities of Bendroflumethiazide.
Amifostine Bendroflumethiazide may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Bendroflumethiazide.
Forasartan Bendroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Forasartan.
Tasosartan Bendroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Tasosartan.
Saralasin Bendroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Saralasin.
Fimasartan Bendroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Fimasartan.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Bendroflumethiazide.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Bendroflumethiazide.
Obinutuzumab Bendroflumethiazide may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Bendroflumethiazide.
Rituximab Bendroflumethiazide may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Bendroflumethiazide.
Eletriptan Eletriptan may decrease the antihypertensive activities of Bendroflumethiazide.
Methysergide Methysergide may decrease the antihypertensive activities of Bendroflumethiazide.
Cabergoline Cabergoline may decrease the antihypertensive activities of Bendroflumethiazide.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Bendroflumethiazide.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Bendroflumethiazide.
Protriptyline Protriptyline may decrease the antihypertensive activities of Bendroflumethiazide.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Bendroflumethiazide.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Bendroflumethiazide.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Bendroflumethiazide.
Droperidol Droperidol may decrease the antihypertensive activities of Bendroflumethiazide.
Doxapram Doxapram may decrease the antihypertensive activities of Bendroflumethiazide.
Lisuride Lisuride may decrease the antihypertensive activities of Bendroflumethiazide.
Metaraminol Metaraminol may decrease the antihypertensive activities of Bendroflumethiazide.
Ergotamine Ergotamine may decrease the antihypertensive activities of Bendroflumethiazide.
Nicergoline Nicergoline may decrease the antihypertensive activities of Bendroflumethiazide.
Methoxamine Methoxamine may decrease the antihypertensive activities of Bendroflumethiazide.
Trimipramine Trimipramine may decrease the antihypertensive activities of Bendroflumethiazide.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Bendroflumethiazide.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Bendroflumethiazide.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Bendroflumethiazide.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Bendroflumethiazide.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Bendroflumethiazide.
Naratriptan Naratriptan may decrease the antihypertensive activities of Bendroflumethiazide.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Bendroflumethiazide.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Bendroflumethiazide.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Bendroflumethiazide.
Dutasteride Dutasteride may decrease the antihypertensive activities of Bendroflumethiazide.
Pergolide Pergolide may decrease the antihypertensive activities of Bendroflumethiazide.
Finasteride Finasteride may decrease the antihypertensive activities of Bendroflumethiazide.
Ergometrine Ergometrine may decrease the antihypertensive activities of Bendroflumethiazide.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Bendroflumethiazide.
Mephentermine Mephentermine may decrease the antihypertensive activities of Bendroflumethiazide.
Yohimbine Yohimbine may decrease the antihypertensive activities of Bendroflumethiazide.
MMDA MMDA may decrease the antihypertensive activities of Bendroflumethiazide.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Bendroflumethiazide.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Bendroflumethiazide.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Bendroflumethiazide.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Bendroflumethiazide.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Bendroflumethiazide.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Bendroflumethiazide.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Bendroflumethiazide.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Bendroflumethiazide.
Periciazine Periciazine may decrease the antihypertensive activities of Bendroflumethiazide.
Acepromazine Acepromazine may decrease the antihypertensive activities of Bendroflumethiazide.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Bendroflumethiazide.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Bendroflumethiazide.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Bendroflumethiazide.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Bendroflumethiazide.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Bendroflumethiazide.
Amineptine Amineptine may decrease the antihypertensive activities of Bendroflumethiazide.
Flibanserin Flibanserin may decrease the antihypertensive activities of Bendroflumethiazide.
Iloperidone Iloperidone may decrease the antihypertensive activities of Bendroflumethiazide.
Amibegron Amibegron may decrease the antihypertensive activities of Bendroflumethiazide.
Naluzotan Naluzotan may decrease the antihypertensive activities of Bendroflumethiazide.
Cariprazine Cariprazine may decrease the antihypertensive activities of Bendroflumethiazide.
Mianserin Mianserin may decrease the antihypertensive activities of Bendroflumethiazide.
Solabegron Solabegron may decrease the antihypertensive activities of Bendroflumethiazide.
Asenapine Asenapine may decrease the antihypertensive activities of Bendroflumethiazide.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Bendroflumethiazide.
Vilazodone Vilazodone may decrease the antihypertensive activities of Bendroflumethiazide.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Bendroflumethiazide.
Xylometazoline Xylometazoline may decrease the antihypertensive activities of Bendroflumethiazide.
Isometheptene Isometheptene may decrease the antihypertensive activities of Bendroflumethiazide.
Naphazoline Naphazoline may decrease the antihypertensive activities of Bendroflumethiazide.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Bendroflumethiazide.
Cinitapride Cinitapride may decrease the antihypertensive activities of Bendroflumethiazide.
Lurasidone Lurasidone may decrease the antihypertensive activities of Bendroflumethiazide.
Tyramine Tyramine may decrease the antihypertensive activities of Bendroflumethiazide.
Adrafinil Adrafinil may decrease the antihypertensive activities of Bendroflumethiazide.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Bendroflumethiazide.
Etilefrine Etilefrine may decrease the antihypertensive activities of Bendroflumethiazide.
Butriptyline Butriptyline may decrease the antihypertensive activities of Bendroflumethiazide.
Cannabidiol Cannabidiol may decrease the antihypertensive activities of Bendroflumethiazide.
Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Bendroflumethiazide.
Cirazoline Cirazoline may decrease the antihypertensive activities of Bendroflumethiazide.
Synephrine Synephrine may decrease the antihypertensive activities of Bendroflumethiazide.
Tianeptine Tianeptine may decrease the antihypertensive activities of Bendroflumethiazide.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Bendroflumethiazide.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Bendroflumethiazide.
Dihydroergocornine Dihydroergocornine may decrease the antihypertensive activities of Bendroflumethiazide.
Amitraz Amitraz may decrease the antihypertensive activities of Bendroflumethiazide.
Medetomidine Medetomidine may decrease the antihypertensive activities of Bendroflumethiazide.

Target Protein

Solute carrier family 12 member 3 SLC12A3
Solute carrier family 12 member 1 SLC12A1
Calcium-activated potassium channel subunit alpha-1 KCNMA1
Carbonic anhydrase 1 CA1
Carbonic anhydrase 2 CA2
Carbonic anhydrase 4 CA4

Referensi & Sumber

Synthesis reference: Goldberg, M.; U.S. Patent 3,265,573; August 9, 1966; assigned to E.R. Squibb & Sons, Inc. Lund, F., Lyngby, K. and Godtfredsen, W.O.; U.S. Patent 3,392,168; July 9, 1968; assigned to Lovens Kemiske Fabrik ved A. Kongsted, Denmark.

Contoh Produk & Brand

Produk: 13 • International brands: 4
Produk
  • Corzide
    Tablet • - • Oral • US • Approved
  • Corzide
    Tablet • - • Oral • US • Approved
  • Corzide
    Tablet • - • Oral • US • Approved
  • Corzide
    Tablet • - • Oral • US • Approved
  • Corzide
    Tablet • - • Oral • US • Approved
  • Corzide Tab W Nadolol 40mg
    Tablet • - • Oral • Canada • Approved
  • Corzide Tab W Nadolol 80mg
    Tablet • - • Oral • Canada • Approved
  • Nadolol and Bendroflumethiazide
    Tablet • - • Oral • US • Generic • Approved
Menampilkan 8 dari 13 produk.
International Brands
  • Aprinox — Sovereign Medical
  • Centyl — LEO Pharma
  • Neo-Naclex — GlaxoSmithKline
  • Salures — Pfizer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul