Famciclovir

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10 hours

Volume Distribusi * 1.08±0.17 L/kg [healthy male subjects following a single intravenous dose of penciclovir at 400 mg administered as a 1-hour intravenous infusion]

Klirens (Clearance) * 36.6 +/- 6.3 L/hr [healthy male] * 0.48 +/- 0.09 L/hr/kg [healthy male]

Absorpsi

77 %

Metabolisme

Hepatic

Rute Eliminasi

Active tubular secretion contributes to the renal elimination of penciclovir.

Interaksi Makanan

1 Data

1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

14 Data

Varicella zoster vaccine (live/attenuated)	The therapeutic efficacy of Varicella zoster vaccine (live/attenuated) can be decreased when used in combination with Famciclovir.
Rubella virus vaccine	The therapeutic efficacy of Rubella virus vaccine can be decreased when used in combination with Famciclovir.
Bacillus calmette-guerin substrain tice live antigen	The therapeutic efficacy of Bacillus calmette-guerin substrain tice live antigen can be decreased when used in combination with Famciclovir.
Bacillus calmette-guerin substrain connaught live antigen	The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Famciclovir.
Yellow fever vaccine	The therapeutic efficacy of Yellow fever vaccine can be decreased when used in combination with Famciclovir.
Anthrax vaccine	The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Famciclovir.
Typhoid Vaccine Live	The therapeutic efficacy of Typhoid Vaccine Live can be decreased when used in combination with Famciclovir.
BCG vaccine	The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Famciclovir.
Human adenovirus e serotype 4 strain cl-68578 antigen	The therapeutic efficacy of Human adenovirus e serotype 4 strain cl-68578 antigen can be decreased when used in combination with Famciclovir.
Vibrio cholerae CVD 103-HgR strain live antigen	The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Famciclovir.
Adenovirus type 7 vaccine live	The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Famciclovir.
Bacillus calmette-guerin substrain russian BCG-I live antigen	The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Famciclovir.
Chikungunya vaccine (live, attenuated)	The therapeutic efficacy of Chikungunya vaccine (live, attenuated) can be decreased when used in combination with Famciclovir.
Smallpox (Vaccinia) Vaccine, Live	The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Famciclovir.

Target Protein

DNA polymerase catalytic subunit

Referensi & Sumber

Link

FDA Approved Drug Products: Famvir (famciclovir) tablets for oral use

Contoh Produk & Brand

Produk: 114 • International brands: 15

Produk

Act Famciclovir

Tablet • 125 mg • Oral • Canada • Approved
Act Famciclovir

Tablet • 250 mg • Oral • Canada • Approved
Act Famciclovir

Tablet • 500 mg • Oral • Canada • Approved
Apo-famciclovir

Tablet • 125 mg • Oral • Canada • Generic • Approved
Apo-famciclovir

Tablet • 250 mg • Oral • Canada • Generic • Approved
Apo-famciclovir

Tablet • 500 mg • Oral • Canada • Generic • Approved
Auro-famciclovir

Tablet • 125 mg • Oral • Canada • Generic • Approved
Auro-famciclovir

Tablet • 250 mg • Oral • Canada • Generic • Approved

Menampilkan 8 dari 114 produk.

International Brands

Ezovir — Alphapharm
Fambir — Il Hwa
Famcino — Daewoong
Famcir — Kwang Dong
Famvir Once — Novartis
Fanclomax — Blausiegel
Fanle — Jialin
Microvir — Micro Gratia
Oravir — Novartis
Pentavir — Fortbenton

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan

Deskripsi

Struktur Molekul 2D

Deskripsi metode visualisasi