Peringatan Keamanan

Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.

Promazine

DB00420

small molecule approved vet_approved

Deskripsi

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.

Struktur Molekul 2D

Berat 284.419
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorption may be erratic and peak plasma concentrations show large interindividual differences.

Metabolisme

Hepatic, primarily to N-desmethylpromazine and promazine sulfoxide.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Additive CNS depression may occur if alcohol is consumed.
  • 2. Avoid antacids. The absorption of promazine may be reduced by antacid use.

Interaksi Obat

1929 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Promazine.
Deferasirox The serum concentration of Promazine can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Promazine can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Promazine can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Promazine can be decreased when it is combined with Teriflunomide.
Remikiren Promazine may decrease the antihypertensive activities of Remikiren.
Guanadrel Promazine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Promazine may decrease the antihypertensive activities of Olmesartan.
Nitroprusside Promazine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Promazine may decrease the antihypertensive activities of Minoxidil.
Fosinopril Promazine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Promazine may decrease the antihypertensive activities of Trandolapril.
Benazepril Promazine may decrease the antihypertensive activities of Benazepril.
Cyclothiazide Promazine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Promazine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Promazine may decrease the antihypertensive activities of Mecamylamine.
Lisinopril Promazine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Promazine may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Promazine may decrease the antihypertensive activities of Cryptenamine.
Eprosartan Promazine may decrease the antihypertensive activities of Eprosartan.
Quinapril Promazine may decrease the antihypertensive activities of Quinapril.
Telmisartan Promazine may decrease the antihypertensive activities of Telmisartan.
Deserpidine Promazine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Promazine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Promazine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Promazine may decrease the antihypertensive activities of Diazoxide.
Epoprostenol Promazine may decrease the antihypertensive activities of Epoprostenol.
Cilazapril Promazine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Promazine may decrease the antihypertensive activities of Saprisartan.
Spirapril Promazine may decrease the antihypertensive activities of Spirapril.
Diethylnorspermine Promazine may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Promazine may decrease the antihypertensive activities of Temocapril.
Nicorandil Promazine may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Promazine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Promazine may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Promazine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Promazine may decrease the antihypertensive activities of Imidapril.
BQ-123 Promazine may decrease the antihypertensive activities of BQ-123.
Zofenopril Promazine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Promazine may decrease the antihypertensive activities of Guanoxan.
Delapril Promazine may decrease the antihypertensive activities of Delapril.
Vincamine Promazine may decrease the antihypertensive activities of Vincamine.
Linsidomine Promazine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Promazine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Promazine may decrease the antihypertensive activities of Tolonidine.
Endralazine Promazine may decrease the antihypertensive activities of Endralazine.
Cadralazine Promazine may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Promazine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Promazine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Promazine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Promazine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Promazine may decrease the antihypertensive activities of Muzolimine.
Xipamide Promazine may decrease the antihypertensive activities of Xipamide.
Tocopherylquinone Promazine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Promazine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Promazine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Promazine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Promazine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Promazine may decrease the antihypertensive activities of Quinaprilat.
Furosemide Promazine may decrease the antihypertensive activities of Furosemide.
Enalapril Promazine may decrease the antihypertensive activities of Enalapril.
Captopril Promazine may decrease the antihypertensive activities of Captopril.
Eplerenone Promazine may decrease the antihypertensive activities of Eplerenone.
Irbesartan Promazine may decrease the antihypertensive activities of Irbesartan.
Guanethidine Promazine may decrease the antihypertensive activities of Guanethidine.
Hydralazine Promazine may decrease the antihypertensive activities of Hydralazine.
Ambrisentan Promazine may decrease the antihypertensive activities of Ambrisentan.
Pinacidil Promazine may decrease the antihypertensive activities of Pinacidil.
Riociguat Promazine may decrease the antihypertensive activities of Riociguat.
Macitentan Promazine may decrease the antihypertensive activities of Macitentan.
Aliskiren Promazine may decrease the antihypertensive activities of Aliskiren.
Selexipag Promazine may decrease the antihypertensive activities of Selexipag.
Ramipril Promazine may decrease the antihypertensive activities of Ramipril.
Perindopril Promazine may decrease the antihypertensive activities of Perindopril.
Levamlodipine Promazine may decrease the antihypertensive activities of Levamlodipine.
Buthiazide Promazine may decrease the antihypertensive activities of Buthiazide.
Azilsartan medoxomil Promazine may decrease the antihypertensive activities of Azilsartan medoxomil.
Buprenorphine Promazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Hydrocodone Promazine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Promazine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Promazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Orphenadrine Promazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Promazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Rotigotine Promazine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Promazine.
Sodium oxybate Promazine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Promazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Thalidomide Promazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Promazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Aclidinium The risk or severity of adverse effects can be increased when Promazine is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Promazine.
Mirabegron The risk or severity of urinary retention can be increased when Promazine is combined with Mirabegron.
Potassium chloride The risk or severity of gastrointestinal ulceration can be increased when Promazine is combined with Potassium chloride.

Target Protein

D(2) dopamine receptor DRD2
Muscarinic acetylcholine receptor M5 CHRM5
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2C HTR2C
Alpha-1A adrenergic receptor ADRA1A
Muscarinic acetylcholine receptor M1 CHRM1
Histamine H1 receptor HRH1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 21685861
    Cubala WJ, Jakuszkowiak-Wojten K, Burkiewicz A, Wronska A: Promazine in the treatment of delusional parasitosis. Psychiatr Danub. 2011 Jun;23(2):198-9.

Contoh Produk & Brand

Produk: 1 • International brands: 4
Produk
  • Promazine HCl Inj 50mg/ml
    Liquid • 50 mg / mL • Intramuscular; Intravenous • Canada • Approved
International Brands
  • Combelen
  • Prazine — Pliva
  • Sparine
  • Talofen — Abbott

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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