Peringatan Keamanan

Symptoms of overdose may include excessive bleeding and bruising.

Ardeparin

DB00407

small molecule approved investigational withdrawn

Deskripsi

Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. Normiflo was withdrawn from the US market in March 2000.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Elimination half-life for anti-factor Xa activity averages 3.3 hours following a single intravenous dose, while elimination half-life for anti-factor IIa activity averages 1.2 hours following a single intravenous dose.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity).

Metabolisme

Liver and the reticulo-endothelial system are the sites of biotransformation.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include ginseng, ginkgo, ginger, and garlic.

Interaksi Obat

860 Data
Apixaban Apixaban may increase the anticoagulant activities of Ardeparin.
Dabigatran etexilate Dabigatran etexilate may increase the anticoagulant activities of Ardeparin.
Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Ardeparin.
Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Ardeparin is combined with Deferasirox.
Ursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Cholic Acid.
Glycocholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Taurocholic acid.
Obeticholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of bleeding and bruising can be increased when Ardeparin is combined with Hyodeoxycholic Acid.
Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Ardeparin.
Ibrutinib The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Ardeparin.
Obinutuzumab The risk or severity of bleeding and hemorrhage can be increased when Ardeparin is combined with Obinutuzumab.
Rivaroxaban Ardeparin may increase the anticoagulant activities of Rivaroxaban.
Sugammadex The risk or severity of bleeding and hemorrhage can be increased when Ardeparin is combined with Sugammadex.
Tibolone Tibolone may increase the anticoagulant activities of Ardeparin.
Tipranavir The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Ardeparin.
Urokinase Urokinase may increase the anticoagulant activities of Ardeparin.
Vitamin E Vitamin E may increase the anticoagulant activities of Ardeparin.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Ardeparin.
Trandolaprilat The risk or severity of hyperkalemia can be increased when Trandolaprilat is combined with Ardeparin.
Moexiprilat The risk or severity of hyperkalemia can be increased when Moexiprilat is combined with Ardeparin.
Cilazaprilat The risk or severity of hyperkalemia can be increased when Cilazaprilat is combined with Ardeparin.
Ginkgo biloba Ginkgo biloba may increase the anticoagulant activities of Ardeparin.
Ifosfamide The risk or severity of bleeding can be increased when Ifosfamide is combined with Ardeparin.
Quinine The therapeutic efficacy of Ardeparin can be increased when used in combination with Quinine.
Quinidine The therapeutic efficacy of Ardeparin can be increased when used in combination with Quinidine.
Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Ardeparin.
Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Ardeparin.
Corticorelin ovine triflutate The risk or severity of hypotension and sinus node depression can be increased when Ardeparin is combined with Corticorelin ovine triflutate.
Oritavancin The therapeutic efficacy of Ardeparin can be decreased when used in combination with Oritavancin.
Streptokinase Streptokinase may increase the anticoagulant activities of Ardeparin.
Telavancin The therapeutic efficacy of Ardeparin can be decreased when used in combination with Telavancin.
Palifermin The serum concentration of Palifermin can be increased when it is combined with Ardeparin.
Pentoxifylline The therapeutic efficacy of Ardeparin can be increased when used in combination with Pentoxifylline.
Pentosan polysulfate Pentosan polysulfate may increase the anticoagulant activities of Ardeparin.
Levocarnitine The therapeutic efficacy of Ardeparin can be increased when used in combination with Levocarnitine.
Diethylstilbestrol Diethylstilbestrol may decrease the anticoagulant activities of Ardeparin.
Chlorotrianisene Chlorotrianisene may decrease the anticoagulant activities of Ardeparin.
Conjugated estrogens Conjugated estrogens may decrease the anticoagulant activities of Ardeparin.
Mestranol The risk or severity of adverse effects can be increased when Mestranol is combined with Ardeparin.
Estrone sulfate Estrone sulfate may decrease the anticoagulant activities of Ardeparin.
Quinestrol Quinestrol may decrease the anticoagulant activities of Ardeparin.
Hexestrol Hexestrol may decrease the anticoagulant activities of Ardeparin.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Ardeparin.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Ardeparin.
Polyestradiol phosphate Polyestradiol phosphate may decrease the anticoagulant activities of Ardeparin.
Esterified estrogens Esterified estrogens may decrease the anticoagulant activities of Ardeparin.
Zeranol Zeranol may decrease the anticoagulant activities of Ardeparin.
Equol Equol may decrease the anticoagulant activities of Ardeparin.
Methallenestril Methallenestril may decrease the anticoagulant activities of Ardeparin.
Epimestrol Epimestrol may decrease the anticoagulant activities of Ardeparin.
Moxestrol Moxestrol may decrease the anticoagulant activities of Ardeparin.
Estradiol acetate Estradiol acetate may decrease the anticoagulant activities of Ardeparin.
Estradiol benzoate Estradiol benzoate may decrease the anticoagulant activities of Ardeparin.
Estradiol cypionate Estradiol cypionate may decrease the anticoagulant activities of Ardeparin.
Estradiol valerate Estradiol valerate may decrease the anticoagulant activities of Ardeparin.
Biochanin A Biochanin A may decrease the anticoagulant activities of Ardeparin.
Formononetin Formononetin may decrease the anticoagulant activities of Ardeparin.
Estriol Estriol may decrease the anticoagulant activities of Ardeparin.
Limaprost The risk or severity of adverse effects can be increased when Limaprost is combined with Ardeparin.
Icosapent The risk or severity of bleeding and hemorrhage can be increased when Icosapent is combined with Ardeparin.
Mesalazine The risk or severity of bleeding can be increased when Mesalazine is combined with Ardeparin.
Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Ardeparin.
Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Ardeparin.
Ketorolac The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Ardeparin.
Tenoxicam The risk or severity of bleeding and hemorrhage can be increased when Tenoxicam is combined with Ardeparin.
Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Ardeparin.
Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Ardeparin.
Rofecoxib The risk or severity of bleeding and hemorrhage can be increased when Rofecoxib is combined with Ardeparin.
Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Ardeparin.
Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Ardeparin.
Valdecoxib The risk or severity of bleeding and hemorrhage can be increased when Valdecoxib is combined with Ardeparin.
Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Ardeparin.
Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Ardeparin.
Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Ardeparin.
Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Ardeparin.
Mefenamic acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Ardeparin.
Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Ardeparin.
Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Ardeparin.
Phenylbutazone The risk or severity of bleeding and hemorrhage can be increased when Phenylbutazone is combined with Ardeparin.
Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Ardeparin.
Carprofen The risk or severity of bleeding and hemorrhage can be increased when Carprofen is combined with Ardeparin.
Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Ardeparin.
Salicylic acid The risk or severity of bleeding and hemorrhage can be increased when Salicylic acid is combined with Ardeparin.
Meclofenamic acid The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Ardeparin.
Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Ardeparin.
Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Ardeparin.
Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Ardeparin.
Olsalazine The risk or severity of bleeding can be increased when Ardeparin is combined with Olsalazine.
Lumiracoxib The risk or severity of bleeding and hemorrhage can be increased when Lumiracoxib is combined with Ardeparin.
Magnesium salicylate The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with Ardeparin.
Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Ardeparin.

Target Protein

Antithrombin-III SERPINC1
Heparin cofactor 2 SERPIND1

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Normiflo — Wyeth-Ayerst (United States)

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul