Peringatan Keamanan

Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions.

Griseofulvin

DB00400

small molecule approved investigational vet_approved

Deskripsi

An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.

Struktur Molekul 2D

Berat 352.766
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 9-21 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.

Metabolisme

Primarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with a high fat meal.

Interaksi Obat

241 Data
Cyclosporine The serum concentration of Cyclosporine can be decreased when it is combined with Griseofulvin.
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Griseofulvin.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Griseofulvin.
Butalbital The serum concentration of Griseofulvin can be decreased when it is combined with Butalbital.
Pentobarbital The serum concentration of Griseofulvin can be decreased when it is combined with Pentobarbital.
Secobarbital The serum concentration of Griseofulvin can be decreased when it is combined with Secobarbital.
Methohexital The serum concentration of Griseofulvin can be decreased when it is combined with Methohexital.
Thiopental The serum concentration of Griseofulvin can be decreased when it is combined with Thiopental.
Primidone The serum concentration of Griseofulvin can be decreased when it is combined with Primidone.
Methylphenobarbital The serum concentration of Griseofulvin can be decreased when it is combined with Methylphenobarbital.
Thiamylal The serum concentration of Griseofulvin can be decreased when it is combined with Thiamylal.
Phenobarbital The serum concentration of Griseofulvin can be decreased when it is combined with Phenobarbital.
Amobarbital The serum concentration of Griseofulvin can be decreased when it is combined with Amobarbital.
Hexobarbital The serum concentration of Griseofulvin can be decreased when it is combined with Hexobarbital.
Barbital The serum concentration of Griseofulvin can be decreased when it is combined with Barbital.
Barbexaclone The serum concentration of Griseofulvin can be decreased when it is combined with Barbexaclone.
Butabarbital The serum concentration of Griseofulvin can be decreased when it is combined with Butabarbital.
Carbocisteine The risk or severity of adverse effects can be increased when Griseofulvin is combined with Carbocisteine.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Griseofulvin.
Perampanel The metabolism of Perampanel can be increased when combined with Griseofulvin.
Warfarin The metabolism of Warfarin can be increased when combined with Griseofulvin.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Griseofulvin.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Griseofulvin.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Griseofulvin.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Griseofulvin.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Griseofulvin.
Ethanol The risk or severity of adverse effects can be increased when Griseofulvin is combined with Ethanol.
Diethylstilbestrol The metabolism of Diethylstilbestrol can be increased when combined with Griseofulvin.
Etonogestrel The metabolism of Etonogestrel can be increased when combined with Griseofulvin.
Desogestrel The metabolism of Desogestrel can be increased when combined with Griseofulvin.
Megestrol acetate The metabolism of Megestrol acetate can be increased when combined with Griseofulvin.
Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Griseofulvin.
Progesterone The metabolism of Progesterone can be increased when combined with Griseofulvin.
Medroxyprogesterone acetate The metabolism of Medroxyprogesterone acetate can be increased when combined with Griseofulvin.
Norethisterone The metabolism of Norethisterone can be increased when combined with Griseofulvin.
Estradiol The metabolism of Estradiol can be increased when combined with Griseofulvin.
Ethynodiol diacetate The metabolism of Ethynodiol diacetate can be increased when combined with Griseofulvin.
Mifepristone The metabolism of Mifepristone can be increased when combined with Griseofulvin.
Norgestimate The metabolism of Norgestimate can be increased when combined with Griseofulvin.
Ethinylestradiol The metabolism of Ethinylestradiol can be increased when combined with Griseofulvin.
Mestranol The metabolism of Mestranol can be increased when combined with Griseofulvin.
Drospirenone The metabolism of Drospirenone can be increased when combined with Griseofulvin.
Estrone sulfate The metabolism of Estrone sulfate can be increased when combined with Griseofulvin.
Octylphenoxy polyethoxyethanol The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Griseofulvin.
Cyproterone acetate The metabolism of Cyproterone acetate can be increased when combined with Griseofulvin.
Trestolone The metabolism of Trestolone can be increased when combined with Griseofulvin.
Norelgestromin The metabolism of Norelgestromin can be increased when combined with Griseofulvin.
Gestodene The metabolism of Gestodene can be increased when combined with Griseofulvin.
Hydroxyprogesterone caproate The metabolism of Hydroxyprogesterone caproate can be increased when combined with Griseofulvin.
Dienogest The metabolism of Dienogest can be increased when combined with Griseofulvin.
Norethynodrel The metabolism of Norethynodrel can be increased when combined with Griseofulvin.
Norgestrel The metabolism of Norgestrel can be increased when combined with Griseofulvin.
Cloprostenol The metabolism of Cloprostenol can be increased when combined with Griseofulvin.
Gestrinone The metabolism of Gestrinone can be increased when combined with Griseofulvin.
Nomegestrol The metabolism of Nomegestrol can be increased when combined with Griseofulvin.
Lynestrenol The metabolism of Lynestrenol can be increased when combined with Griseofulvin.
Gossypol The metabolism of Gossypol can be increased when combined with Griseofulvin.
Ormeloxifene The metabolism of Ormeloxifene can be increased when combined with Griseofulvin.
Chlormadinone The metabolism of Chlormadinone can be increased when combined with Griseofulvin.
Norgestrienone The metabolism of Norgestrienone can be increased when combined with Griseofulvin.
Quingestanol The metabolism of Quingestanol can be increased when combined with Griseofulvin.
Demegestone The metabolism of Demegestone can be increased when combined with Griseofulvin.
Etynodiol The metabolism of Etynodiol can be increased when combined with Griseofulvin.
Testosterone enanthate The metabolism of Testosterone enanthate can be increased when combined with Griseofulvin.
Estradiol benzoate The metabolism of Estradiol benzoate can be increased when combined with Griseofulvin.
Estradiol cypionate The metabolism of Estradiol cypionate can be increased when combined with Griseofulvin.
Estradiol valerate The metabolism of Estradiol valerate can be increased when combined with Griseofulvin.
Nomegestrol acetate The metabolism of Nomegestrol acetate can be increased when combined with Griseofulvin.
Norethindrone enanthate The metabolism of Norethindrone enanthate can be increased when combined with Griseofulvin.
Ulipristal The metabolism of Ulipristal can be increased when combined with Griseofulvin.
Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Griseofulvin.
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Griseofulvin.
Azithromycin The metabolism of Azithromycin can be increased when combined with Griseofulvin.
Ziprasidone The metabolism of Ziprasidone can be increased when combined with Griseofulvin.
Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Griseofulvin.
Albendazole The metabolism of Albendazole can be increased when combined with Griseofulvin.
Cephalexin The metabolism of Cephalexin can be increased when combined with Griseofulvin.
Doxazosin The metabolism of Doxazosin can be increased when combined with Griseofulvin.
Fenofibrate The metabolism of Fenofibrate can be increased when combined with Griseofulvin.
Atazanavir The metabolism of Atazanavir can be increased when combined with Griseofulvin.
Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Griseofulvin.
Allylestrenol The metabolism of Allylestrenol can be increased when combined with Griseofulvin.
Zuclopenthixol The metabolism of Zuclopenthixol can be increased when combined with Griseofulvin.
Roflumilast The metabolism of Roflumilast can be increased when combined with Griseofulvin.
Lacosamide The metabolism of Lacosamide can be increased when combined with Griseofulvin.
Linagliptin The metabolism of Linagliptin can be increased when combined with Griseofulvin.
Vorapaxar The metabolism of Vorapaxar can be increased when combined with Griseofulvin.
Suvorexant The metabolism of Suvorexant can be increased when combined with Griseofulvin.
Netupitant The metabolism of Netupitant can be increased when combined with Griseofulvin.
Tasimelteon The metabolism of Tasimelteon can be increased when combined with Griseofulvin.
Nintedanib The metabolism of Nintedanib can be increased when combined with Griseofulvin.
Tenofovir alafenamide The metabolism of Tenofovir alafenamide can be increased when combined with Griseofulvin.
Dihydroergocornine The metabolism of Dihydroergocornine can be increased when combined with Griseofulvin.
Duvelisib The metabolism of Duvelisib can be increased when combined with Griseofulvin.
Gilteritinib The metabolism of Gilteritinib can be increased when combined with Griseofulvin.
9-aminocamptothecin The metabolism of 9-aminocamptothecin can be increased when combined with Griseofulvin.
Methylprednisone The metabolism of Methylprednisone can be increased when combined with Griseofulvin.
Dihydroergocristine The metabolism of Dihydroergocristine can be increased when combined with Griseofulvin.
Dihydroergocryptine The metabolism of Dihydroergocryptine can be increased when combined with Griseofulvin.
Medical Cannabis The metabolism of Medical Cannabis can be increased when combined with Griseofulvin.

Target Protein

Tubulin beta chain
Keratin, type I cytoskeletal 12 KRT12

Referensi & Sumber

Synthesis reference: Gary Liversidge, "Methods of making and using novel griseofulvin compositions." U.S. Patent US20070098805, issued May 03, 2007.

Contoh Produk & Brand

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International Brands
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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