Peringatan Keamanan

Symptoms of overdosage would be expected to be related to cardiovascular effects such as excessive peripheral vasodilation with marked systemic hypotension.

Nimodipine

DB00393

small molecule approved investigational

Deskripsi

Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation. Nimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.

Struktur Molekul 2D

Berat 418.4403
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.7-9 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

In humans, nimodipine is rapidly absorbed after oral administration, and peak concentrations are generally attained within one hour. Bioavailability is 100% following intravenous administration and 3-30% following oral administration due to extensive first-pass metabolism.

Metabolisme

Hepatic metabolism via CYP 3A4.

Rute Eliminasi

Nimodipine is eliminated almost exclusively in the form of metabolites and less than 1% is recovered in the urine as unchanged drug. Numerous metabolites, all of which are either inactive or considerably less active than the parent compound, have been identified.

Interaksi Makanan

2 Data
  • 1. Avoid grapefruit products.
  • 2. Take with or without food. Take consistently at the same time in regard to meals.

Interaksi Obat

1294 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Nimodipine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Nimodipine is combined with Levodopa.
Risperidone Nimodipine may increase the hypotensive activities of Risperidone.
Ceritinib Nimodipine may increase the bradycardic activities of Ceritinib.
Ivabradine Nimodipine may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Nimodipine.
Alfuzosin Alfuzosin may increase the hypotensive activities of Nimodipine.
Amifostine Nimodipine may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Nimodipine.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Nimodipine.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Nimodipine.
Obinutuzumab Nimodipine may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Nimodipine.
Rituximab Nimodipine may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Nimodipine.
Isoetharine Isoetharine may decrease the antihypertensive activities of Nimodipine.
Etomidate Etomidate may decrease the antihypertensive activities of Nimodipine.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Nimodipine.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Nimodipine.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Nimodipine.
Doxapram Doxapram may decrease the antihypertensive activities of Nimodipine.
Metaraminol Metaraminol may decrease the antihypertensive activities of Nimodipine.
Methoxamine Methoxamine may decrease the antihypertensive activities of Nimodipine.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Nimodipine.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Nimodipine.
Dobutamine Dobutamine may decrease the antihypertensive activities of Nimodipine.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Nimodipine.
Ritodrine Ritodrine may decrease the antihypertensive activities of Nimodipine.
Bitolterol Bitolterol may decrease the antihypertensive activities of Nimodipine.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Nimodipine.
Naratriptan Naratriptan may decrease the antihypertensive activities of Nimodipine.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Nimodipine.
Dopamine Dopamine may decrease the antihypertensive activities of Nimodipine.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Nimodipine.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Nimodipine.
Arbutamine Arbutamine may decrease the antihypertensive activities of Nimodipine.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Nimodipine.
Fenoterol Fenoterol may decrease the antihypertensive activities of Nimodipine.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Nimodipine.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Nimodipine.
Ephedrine Ephedrine may decrease the antihypertensive activities of Nimodipine.
Mephentermine Mephentermine may decrease the antihypertensive activities of Nimodipine.
Procaterol Procaterol may decrease the antihypertensive activities of Nimodipine.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Nimodipine.
Bambuterol Bambuterol may decrease the antihypertensive activities of Nimodipine.
MMDA MMDA may decrease the antihypertensive activities of Nimodipine.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Nimodipine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Nimodipine.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Nimodipine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Nimodipine.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Nimodipine.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Nimodipine.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Nimodipine.
Metamfetamine Metamfetamine may decrease the antihypertensive activities of Nimodipine.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Nimodipine.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Nimodipine.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Nimodipine.
Amineptine Amineptine may decrease the antihypertensive activities of Nimodipine.
Amibegron Amibegron may decrease the antihypertensive activities of Nimodipine.
Naluzotan Naluzotan may decrease the antihypertensive activities of Nimodipine.
Solabegron Solabegron may decrease the antihypertensive activities of Nimodipine.
Droxidopa Droxidopa may decrease the antihypertensive activities of Nimodipine.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Nimodipine.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Nimodipine.
Isometheptene Isometheptene may decrease the antihypertensive activities of Nimodipine.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Nimodipine.
Naphazoline Naphazoline may decrease the antihypertensive activities of Nimodipine.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Nimodipine.
Cinitapride Cinitapride may decrease the antihypertensive activities of Nimodipine.
Tyramine Tyramine may decrease the antihypertensive activities of Nimodipine.
Adrafinil Adrafinil may decrease the antihypertensive activities of Nimodipine.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Nimodipine.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Nimodipine.
Etilefrine Etilefrine may decrease the antihypertensive activities of Nimodipine.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Nimodipine.
Cirazoline Cirazoline may decrease the antihypertensive activities of Nimodipine.
Synephrine Synephrine may decrease the antihypertensive activities of Nimodipine.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Nimodipine.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Nimodipine.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Nimodipine.
Racepinephrine Racepinephrine may decrease the antihypertensive activities of Nimodipine.
DL-Methylephedrine DL-Methylephedrine may decrease the antihypertensive activities of Nimodipine.
Amitraz Amitraz may decrease the antihypertensive activities of Nimodipine.
Medetomidine Medetomidine may decrease the antihypertensive activities of Nimodipine.
Xylazine Xylazine may decrease the antihypertensive activities of Nimodipine.
Atipamezole Atipamezole may decrease the antihypertensive activities of Nimodipine.
Ractopamine Ractopamine may decrease the antihypertensive activities of Nimodipine.
Romifidine Romifidine may decrease the antihypertensive activities of Nimodipine.
Detomidine Detomidine may decrease the antihypertensive activities of Nimodipine.
Etafedrine Etafedrine may decrease the antihypertensive activities of Nimodipine.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Nimodipine.
PF-00610355 PF-00610355 may decrease the antihypertensive activities of Nimodipine.
Ritobegron Ritobegron may decrease the antihypertensive activities of Nimodipine.
Abediterol Abediterol may decrease the antihypertensive activities of Nimodipine.
Tulobuterol Tulobuterol may decrease the antihypertensive activities of Nimodipine.
Dopexamine Dopexamine may decrease the antihypertensive activities of Nimodipine.
Piclozotan Piclozotan may decrease the antihypertensive activities of Nimodipine.
Idazoxan Idazoxan may decrease the antihypertensive activities of Nimodipine.
Higenamine Higenamine may decrease the antihypertensive activities of Nimodipine.
Reproterol Reproterol may decrease the antihypertensive activities of Nimodipine.

Target Protein

Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F
Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S
Voltage-dependent L-type calcium channel subunit beta-1 CACNB1
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2
Voltage-dependent L-type calcium channel subunit beta-3 CACNB3
Voltage-dependent L-type calcium channel subunit beta-4 CACNB4
Mineralocorticoid receptor NR3C2
Aryl hydrocarbon receptor AHR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12657973
    Janjua N, Mayer SA: Cerebral vasospasm after subarachnoid hemorrhage. Curr Opin Crit Care. 2003 Apr;9(2):113-9.
  • PMID: 6338383
    Allen GS, Ahn HS, Preziosi TJ, Battye R, Boone SC, Boone SC, Chou SN, Kelly DL, Weir BK, Crabbe RA, Lavik PJ, Rosenbloom SB, Dorsey FC, Ingram CR, Mellits DE, Bertsch LA, Boisvert DP, Hundley MB, Johnson RK, Strom JA, Transou CR: Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med. 1983 Mar 17;308(11):619-24.
  • PMID: 12540643
    Belfort MA, Anthony J, Saade GR, Allen JC Jr: A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. N Engl J Med. 2003 Jan 23;348(4):304-11.
  • PMID: 19844625
    Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc. 2009 Sep;46(3):239-44. doi: 10.3340/jkns.2009.46.3.239. Epub 2009 Sep 30.
  • PMID: 19021025
    Tomassoni D, Lanari A, Silvestrelli G, Traini E, Amenta F: Nimodipine and its use in cerebrovascular disease: evidence from recent preclinical and controlled clinical studies. Clin Exp Hypertens. 2008 Nov;30(8):744-66. doi: 10.1080/10641960802580232.
  • PMID: 17110283
    Vergouwen MD, Vermeulen M, Roos YB: Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review. Lancet Neurol. 2006 Dec;5(12):1029-32.

Contoh Produk & Brand

Produk: 24 • International brands: 1
Produk
  • Nimodipine
    Capsule, liquid filled • 30 mg/1 • Oral • US • Generic • Approved
  • Nimodipine
    Capsule, liquid filled • 30 mg/1 • Oral • US • Generic • Approved
  • Nimodipine
    Capsule • 30 mg/1 • Oral • US • Generic • Approved
  • Nimodipine
    Capsule, liquid filled • 30 mg/1 • Oral • US • Generic • Approved
  • Nimodipine
    Capsule, liquid filled • 30 mg/1 • Oral • US • Generic • Approved
  • Nimodipine
    Capsule, liquid filled • 30 mg/1 • Oral • US • Generic • Approved
  • Nimodipine
    Capsule, liquid filled • 30 mg/1 • Oral • US • Generic • Approved
  • Nimodipine
    Capsule, liquid filled • 30 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 24 produk.
International Brands
  • Periplum

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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