Peringatan Keamanan

Patients experiencing an overdose of sulpiride may present with hypotension, sinus tachycardia, arrhythmia, dystonia, CNS depression, hallucinations, vomiting, agitation, dysarthria, salivation, as well as increased muscle tone, hyperreflexia, and extensor plantar reflex.A229658 Patients should be treated with symptomatic and supportive treatment.A229658

Sulpiride

DB00391

small molecule approved investigational

Deskripsi

Sulpiride first appeared in published literature in 1967.A229538 Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses.A229683

Sulpiride is not approved by the FDA, Health Canada, or the EMA; though it is approved in individual European countries.L24679

Struktur Molekul 2D

Berat 341.426
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Reports of the half life of sulpiride have only been performed with small numbers of subjects.[A229558,A229653] Therefore, the average half life may be 7.15 hours[A229653] to 8.3 hours.[A229558]
Volume Distribusi The average volume of distribution of sulpiride is 2.72 ± 0.66 L/kg.[A229653]
Klirens (Clearance) The total systemic clearance of sulpiride if 415 ± 84 mL/min, while the mean renal clearance was 310 ± 91 mL/min.[A229653]

Absorpsi

Sulpiride has an oral bioavailability of 27 ± 9%.A229653 A 100-108 mg dose of sulpiride reaches a Cmax of 232-403 ng/mL, with a Tmax of 8.3 h.A229558 In another study, the AUC of a 100mg oral dose of sulpiride is 1156 ± 522 h\*ng/mL and for an intravenous dose is 3981 ± 813 h\*ng/mL.A229653

Metabolisme

95% of a dose of sulpiride is not metabolized.A229558

Rute Eliminasi

An intravenous dose of sulpiride is 70 ± 9% eliminated in the urine within 36 hours, while an oral dose is 27 ± 9% eliminated in urine.A229653 In both cases, the dose is recovered as the unchanged parent compound.A229653

Interaksi Makanan

1 Data
  • 1. Avoid alcohol. Alcohol enhances the sedative effects of sulpiride.

Interaksi Obat

1250 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Sulpiride.
Buprenorphine Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
Hydrocodone Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Sulpiride can be increased when used in combination with Magnesium sulfate.
Metyrosine Sulpiride may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
Mirtazapine Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
Orphenadrine Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
Rotigotine Sulpiride may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Sulpiride.
Sodium oxybate Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
Thalidomide Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Amisulpride Sulpiride may increase the antipsychotic activities of Amisulpride.
Methylphenidate The risk or severity of adverse effects can be increased when Sulpiride is combined with Methylphenidate.
Dexmethylphenidate The risk or severity of adverse effects can be increased when Sulpiride is combined with Dexmethylphenidate.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with Sulpiride.
Quinagolide The therapeutic efficacy of Quinagolide can be decreased when used in combination with Sulpiride.
Reserpine Reserpine may increase the antipsychotic activities of Sulpiride.
Ziprasidone Ziprasidone may increase the antipsychotic activities of Sulpiride.
Olanzapine Olanzapine may increase the antipsychotic activities of Sulpiride.
Clozapine Clozapine may increase the antipsychotic activities of Sulpiride.
Thiethylperazine Thiethylperazine may increase the antipsychotic activities of Sulpiride.
Loxapine Loxapine may increase the antipsychotic activities of Sulpiride.
Remoxipride Remoxipride may increase the antipsychotic activities of Sulpiride.
Promazine Promazine may increase the antipsychotic activities of Sulpiride.
Prochlorperazine Prochlorperazine may increase the antipsychotic activities of Sulpiride.
Droperidol Droperidol may increase the antipsychotic activities of Sulpiride.
Chlorpromazine Chlorpromazine may increase the antipsychotic activities of Sulpiride.
Haloperidol Haloperidol may increase the antipsychotic activities of Sulpiride.
Triflupromazine Triflupromazine may increase the antipsychotic activities of Sulpiride.
Amoxapine Amoxapine may increase the antipsychotic activities of Sulpiride.
Fluphenazine Fluphenazine may increase the antipsychotic activities of Sulpiride.
Thioridazine Thioridazine may increase the antipsychotic activities of Sulpiride.
Moricizine Moricizine may increase the antipsychotic activities of Sulpiride.
Risperidone Risperidone may increase the antipsychotic activities of Sulpiride.
Trifluoperazine Trifluoperazine may increase the antipsychotic activities of Sulpiride.
Perphenazine Perphenazine may increase the antipsychotic activities of Sulpiride.
Flupentixol Flupentixol may increase the antipsychotic activities of Sulpiride.
Mesoridazine Mesoridazine may increase the antipsychotic activities of Sulpiride.
Acetophenazine Acetophenazine may increase the antipsychotic activities of Sulpiride.
Promethazine Promethazine may increase the antipsychotic activities of Sulpiride.
Pimozide Pimozide may increase the antipsychotic activities of Sulpiride.
Quetiapine Quetiapine may increase the antipsychotic activities of Sulpiride.
Aripiprazole Aripiprazole may increase the antipsychotic activities of Sulpiride.
Chlorprothixene Chlorprothixene may increase the antipsychotic activities of Sulpiride.
Alimemazine Alimemazine may increase the antipsychotic activities of Sulpiride.
Paliperidone Paliperidone may increase the antipsychotic activities of Sulpiride.
Lithium cation Lithium cation may increase the antipsychotic activities of Sulpiride.
Methotrimeprazine Methotrimeprazine may increase the antipsychotic activities of Sulpiride.
Periciazine Periciazine may increase the antipsychotic activities of Sulpiride.
Acepromazine Acepromazine may increase the antipsychotic activities of Sulpiride.
Aceprometazine Aceprometazine may increase the antipsychotic activities of Sulpiride.
Molindone Molindone may increase the antipsychotic activities of Sulpiride.
Pipotiazine Pipotiazine may increase the antipsychotic activities of Sulpiride.
Thioproperazine Thioproperazine may increase the antipsychotic activities of Sulpiride.
Thiothixene Thiothixene may increase the antipsychotic activities of Sulpiride.
Zuclopenthixol Zuclopenthixol may increase the antipsychotic activities of Sulpiride.
Fluspirilene Fluspirilene may increase the antipsychotic activities of Sulpiride.
Osanetant Osanetant may increase the antipsychotic activities of Sulpiride.
Bifeprunox Bifeprunox may increase the antipsychotic activities of Sulpiride.
Iloperidone Iloperidone may increase the antipsychotic activities of Sulpiride.
BL-1020 BL-1020 may increase the antipsychotic activities of Sulpiride.
Cariprazine Cariprazine may increase the antipsychotic activities of Sulpiride.
Lumateperone Lumateperone may increase the antipsychotic activities of Sulpiride.
Sertindole Sertindole may increase the antipsychotic activities of Sulpiride.
Asenapine Asenapine may increase the antipsychotic activities of Sulpiride.
Lurasidone Lurasidone may increase the antipsychotic activities of Sulpiride.
Perospirone Perospirone may increase the antipsychotic activities of Sulpiride.
Amperozide Amperozide may increase the antipsychotic activities of Sulpiride.
Cyamemazine Cyamemazine may increase the antipsychotic activities of Sulpiride.
Brexpiprazole Brexpiprazole may increase the antipsychotic activities of Sulpiride.
Blonanserin Blonanserin may increase the antipsychotic activities of Sulpiride.
Melperone Melperone may increase the antipsychotic activities of Sulpiride.
Zotepine Zotepine may increase the antipsychotic activities of Sulpiride.
Brilaroxazine Brilaroxazine may increase the antipsychotic activities of Sulpiride.
Methylene blue Methylene blue may increase the antipsychotic activities of Sulpiride.
Pipamperone Pipamperone may increase the antipsychotic activities of Sulpiride.
Azaperone Azaperone may increase the antipsychotic activities of Sulpiride.
Propiopromazine Propiopromazine may increase the antipsychotic activities of Sulpiride.
Tetrahydropalmatine Tetrahydropalmatine may increase the antipsychotic activities of Sulpiride.
Ecopipam Ecopipam may increase the antipsychotic activities of Sulpiride.
Bromperidol Bromperidol may increase the antipsychotic activities of Sulpiride.
Raclopride Raclopride may increase the antipsychotic activities of Sulpiride.
Ritanserin Ritanserin may increase the antipsychotic activities of Sulpiride.
Perazine Perazine may increase the antipsychotic activities of Sulpiride.
Benperidol Benperidol may increase the antipsychotic activities of Sulpiride.
Prothipendyl Prothipendyl may increase the antipsychotic activities of Sulpiride.
Tiapride Tiapride may increase the antipsychotic activities of Sulpiride.
Butaperazine Butaperazine may increase the antipsychotic activities of Sulpiride.
Clothiapine Clothiapine may increase the antipsychotic activities of Sulpiride.
Sultopride Sultopride may increase the antipsychotic activities of Sulpiride.
Chlorproethazine Chlorproethazine may increase the antipsychotic activities of Sulpiride.

Target Protein

D(2) dopamine receptor DRD2
D(3) dopamine receptor DRD3
Carbonic anhydrase 2 CA2
Carbonic anhydrase 3 CA3
D(4) dopamine receptor DRD4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 4965550
    Justin-Besancon L, Thominet M, Laville C, Margarit J: Chemical consitution and biological properties of sulpiride. C R Acad Hebd Seances Acad Sci D. 1967 Oct 23;265(17):1253-4.
  • PMID: 96745
    Imondi AR, Alam AS, Brennan JJ, Hagerman LM: Metabolism of sulpiride in man and rhesus monkeys. Arch Int Pharmacodyn Ther. 1978 Mar;232(1):79-91.
  • PMID: 26742031
    da Silva Fragoso VM, de Morais Coura CP, Hoppe LY, Soares MA, Silva D, Cortez CM: Binding of Sulpiride to Seric Albumins. Int J Mol Sci. 2016 Jan 4;17(1). pii: ijms17010059. doi: 10.3390/ijms17010059.
  • PMID: 7418717
    Wiesel FA, Alfredsson G, Ehrnebo M, Sedvall G: The pharmacokinetics of intravenous and oral sulpiride in healthy human subjects. Eur J Clin Pharmacol. 1980 May;17(5):385-91. doi: 10.1007/BF00558453.
  • PMID: 11343578
    Capel MM, Colbridge MG, Henry JA: Overdose profiles of new antipsychotic agents. Int J Neuropsychopharmacol. 2000 Mar;3(1):51-54. doi: 10.1017/S1461145700001760.
  • PMID: 7046370
    Jenner P, Marsden CD: The mode of action of sulpiride as an atypical antidepressant agent. Adv Biochem Psychopharmacol. 1982;32:85-103.
  • PMID: 8800626
    Mauri MC, Bravin S, Bitetto A, Rudelli R, Invernizzi G: A risk-benefit assessment of sulpiride in the treatment of schizophrenia. Drug Saf. 1996 May;14(5):288-98. doi: 10.2165/00002018-199614050-00003.
  • PMID: 31244443
    Kecel-Gunduz S, Budama-Kilinc Y, Cakir-Koc R, Zorlu T, Bicak B, Kokcu Y, Kaya Z, Ozel AE, Akyuz S: In silico Analysis of Sulpiride, Synthesis, Characterization and In vitro Studies of its Nanoparticle for the Treatment of Schizophrenia. Curr Comput Aided Drug Des. 2020;16(2):104-121. doi: 10.2174/1573409915666190627125643.
Menampilkan 8 dari 9 artikel.

Contoh Produk & Brand

Produk: 0 • International brands: 8
International Brands
  • Bosnyl
  • Dogmatil
  • Dogmatyl
  • Dolmatil
  • Eglonyl
  • Espiride
  • Meresa
  • Modal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul