Overdosage with cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. The estimated median lethal dose of tacrine following a single oral dose in rats is 40 mg/kg, or approximately 12 times the maximum recommended human dose of 160 mg/day.
A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Deferasirox | The serum concentration of Tacrine can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Tacrine can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Tacrine can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Tacrine can be decreased when it is combined with Teriflunomide. |
| Dipyridamole | The therapeutic efficacy of Tacrine can be decreased when used in combination with Dipyridamole. |
| Ephedrine | Tacrine may increase the neuromuscular blocking activities of Ephedrine. |
| Bambuterol | Tacrine may increase the neuromuscular blocking activities of Bambuterol. |
| Clevidipine | Tacrine may increase the neuromuscular blocking activities of Clevidipine. |
| Sar9, Met (O2)11-Substance P | Tacrine may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P. |
| Moxisylyte | Tacrine may increase the neuromuscular blocking activities of Moxisylyte. |
| Procaine | Tacrine may increase the neuromuscular blocking activities of Procaine. |
| Cocaine | Tacrine may increase the neuromuscular blocking activities of Cocaine. |
| Trimethaphan | Tacrine may increase the neuromuscular blocking activities of Trimethaphan. |
| Doxacurium | Tacrine may increase the neuromuscular blocking activities of Doxacurium. |
| Chloroprocaine | Tacrine may increase the neuromuscular blocking activities of Chloroprocaine. |
| Tubocurarine | Tacrine may increase the neuromuscular blocking activities of Tubocurarine. |
| Aclidinium | Tacrine may increase the neuromuscular blocking activities of Aclidinium. |
| Butyrylthiocholine | Tacrine may increase the neuromuscular blocking activities of Butyrylthiocholine. |
| Mirabegron | Tacrine may increase the neuromuscular blocking activities of Mirabegron. |
| Oxybuprocaine | Tacrine may increase the neuromuscular blocking activities of Oxybuprocaine. |
| Benzonatate | Tacrine may increase the neuromuscular blocking activities of Benzonatate. |
| Succinylcholine | The metabolism of Succinylcholine can be decreased when combined with Tacrine. |
| Abiraterone | The serum concentration of Tacrine can be increased when it is combined with Abiraterone. |
| Cyproterone acetate | The metabolism of Tacrine can be increased when combined with Cyproterone acetate. |
| Tramadol | The therapeutic efficacy of Tramadol can be decreased when used in combination with Tacrine. |
| Trospium | The therapeutic efficacy of Trospium can be decreased when used in combination with Tacrine. |
| Oxyphenonium | The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Tacrine. |
| Butabarbital | The therapeutic efficacy of Butabarbital can be decreased when used in combination with Tacrine. |
| Butalbital | The therapeutic efficacy of Butalbital can be decreased when used in combination with Tacrine. |
| Benzatropine | The therapeutic efficacy of Benzatropine can be decreased when used in combination with Tacrine. |
| Ziprasidone | The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Tacrine. |
| Talbutal | The therapeutic efficacy of Talbutal can be decreased when used in combination with Tacrine. |
| Pentobarbital | The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Tacrine. |
| Ipratropium | The therapeutic efficacy of Ipratropium can be decreased when used in combination with Tacrine. |
| Methadone | The therapeutic efficacy of Methadone can be decreased when used in combination with Tacrine. |
| Metixene | The therapeutic efficacy of Metixene can be decreased when used in combination with Tacrine. |
| Terfenadine | The therapeutic efficacy of Terfenadine can be decreased when used in combination with Tacrine. |
| Buclizine | The therapeutic efficacy of Buclizine can be decreased when used in combination with Tacrine. |
| Doxylamine | The therapeutic efficacy of Doxylamine can be decreased when used in combination with Tacrine. |
| Trihexyphenidyl | The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Tacrine. |
| Oxyphencyclimine | The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Tacrine. |
| Procyclidine | The therapeutic efficacy of Procyclidine can be decreased when used in combination with Tacrine. |
| Profenamine | The therapeutic efficacy of Profenamine can be decreased when used in combination with Tacrine. |
| Hyoscyamine | The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Tacrine. |
| Cyproheptadine | The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Tacrine. |
| Methscopolamine bromide | The therapeutic efficacy of Methscopolamine bromide can be decreased when used in combination with Tacrine. |
| Metharbital | The therapeutic efficacy of Metharbital can be decreased when used in combination with Tacrine. |
| Darifenacin | The therapeutic efficacy of Darifenacin can be decreased when used in combination with Tacrine. |
| Tridihexethyl | The therapeutic efficacy of Tridihexethyl can be decreased when used in combination with Tacrine. |
| Triflupromazine | The therapeutic efficacy of Triflupromazine can be decreased when used in combination with Tacrine. |
| Dextromethorphan | The therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Tacrine. |
| Anisotropine methylbromide | The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Tacrine. |
| Amoxapine | The therapeutic efficacy of Amoxapine can be decreased when used in combination with Tacrine. |
| Atropine | The therapeutic efficacy of Atropine can be decreased when used in combination with Tacrine. |
| Thiopental | The therapeutic efficacy of Thiopental can be decreased when used in combination with Tacrine. |
| Nicardipine | The therapeutic efficacy of Nicardipine can be decreased when used in combination with Tacrine. |
| Mecamylamine | The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Tacrine. |
| Pirenzepine | The therapeutic efficacy of Pirenzepine can be decreased when used in combination with Tacrine. |
| Homatropine methylbromide | The therapeutic efficacy of Homatropine methylbromide can be decreased when used in combination with Tacrine. |
| Scopolamine | The therapeutic efficacy of Scopolamine can be decreased when used in combination with Tacrine. |
| Isoflurane | The therapeutic efficacy of Isoflurane can be decreased when used in combination with Tacrine. |
| Benzquinamide | The therapeutic efficacy of Benzquinamide can be decreased when used in combination with Tacrine. |
| Clidinium | The therapeutic efficacy of Clidinium can be decreased when used in combination with Tacrine. |
| Propiomazine | The therapeutic efficacy of Propiomazine can be decreased when used in combination with Tacrine. |
| Propantheline | The therapeutic efficacy of Propantheline can be decreased when used in combination with Tacrine. |
| Dicyclomine | The therapeutic efficacy of Dicyclomine can be decreased when used in combination with Tacrine. |
| Biperiden | The therapeutic efficacy of Biperiden can be decreased when used in combination with Tacrine. |
| Brompheniramine | The therapeutic efficacy of Brompheniramine can be decreased when used in combination with Tacrine. |
| Methylphenobarbital | The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Tacrine. |
| Amantadine | The therapeutic efficacy of Amantadine can be decreased when used in combination with Tacrine. |
| Methantheline | The therapeutic efficacy of Methantheline can be decreased when used in combination with Tacrine. |
| Hexafluronium | The therapeutic efficacy of Hexafluronium can be decreased when used in combination with Tacrine. |
| Cycrimine | The therapeutic efficacy of Cycrimine can be decreased when used in combination with Tacrine. |
| Desloratadine | The therapeutic efficacy of Desloratadine can be decreased when used in combination with Tacrine. |
| Glycopyrronium | The therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Tacrine. |
| Tolterodine | The therapeutic efficacy of Tolterodine can be decreased when used in combination with Tacrine. |
| Oxybutynin | The therapeutic efficacy of Oxybutynin can be decreased when used in combination with Tacrine. |
| Promethazine | The therapeutic efficacy of Promethazine can be decreased when used in combination with Tacrine. |
| Diphenhydramine | The therapeutic efficacy of Diphenhydramine can be decreased when used in combination with Tacrine. |
| Pentolinium | The therapeutic efficacy of Pentolinium can be decreased when used in combination with Tacrine. |
| Flavoxate | The therapeutic efficacy of Flavoxate can be decreased when used in combination with Tacrine. |
| Escitalopram | The therapeutic efficacy of Escitalopram can be decreased when used in combination with Tacrine. |
| Quetiapine | The therapeutic efficacy of Quetiapine can be decreased when used in combination with Tacrine. |
| Levacetylmethadol | The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Tacrine. |
| Diphenidol | The therapeutic efficacy of Diphenidol can be decreased when used in combination with Tacrine. |
| Aripiprazole | The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Tacrine. |
| Chlorprothixene | The therapeutic efficacy of Chlorprothixene can be decreased when used in combination with Tacrine. |
| Fenoterol | The therapeutic efficacy of Fenoterol can be decreased when used in combination with Tacrine. |
| Amobarbital | The therapeutic efficacy of Amobarbital can be decreased when used in combination with Tacrine. |
| Aprobarbital | The therapeutic efficacy of Aprobarbital can be decreased when used in combination with Tacrine. |
| Butobarbital | The therapeutic efficacy of Butobarbital can be decreased when used in combination with Tacrine. |
| Heptabarbital | The therapeutic efficacy of Heptabarbital can be decreased when used in combination with Tacrine. |
| Hexobarbital | The therapeutic efficacy of Hexobarbital can be decreased when used in combination with Tacrine. |
| Methotrimeprazine | The therapeutic efficacy of Methotrimeprazine can be decreased when used in combination with Tacrine. |
| Tiotropium | The therapeutic efficacy of Tiotropium can be decreased when used in combination with Tacrine. |
| Barbital | The therapeutic efficacy of Barbital can be decreased when used in combination with Tacrine. |
| Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione | The therapeutic efficacy of Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione can be decreased when used in combination with Tacrine. |
| Solifenacin | The therapeutic efficacy of Solifenacin can be decreased when used in combination with Tacrine. |
| Isopropamide | The therapeutic efficacy of Isopropamide can be decreased when used in combination with Tacrine. |
| Mepenzolate | The therapeutic efficacy of Mepenzolate can be decreased when used in combination with Tacrine. |