Peringatan Keamanan

Intraperitoneal, mouse LD10 = 500 mg/kg. Intravenous, dog LD10 = 2 gm/kg.

Dexrazoxane

DB00380

small molecule approved withdrawn

Deskripsi

An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. PubChem
The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.

Struktur Molekul 2D

Berat 268.2691
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.5 hours
Volume Distribusi * 9 to 22.6 L/m^2
Klirens (Clearance) * 7.88 L/h/m2 [dose of 50 mg/m2 Doxorubicin and 500 mg/m2 Dexrazoxane] * 6.25 L/h/m2 [dose of 60 mg/m2 Doxorubicin and 600 mg/m2 Dexrazoxane]

Absorpsi

IV administration results in complete bioavailability.

Metabolisme

Dexrazoxane is hydrolysed by the enzyme dihydropyrimidine amidohydrolase in the liver and kidney to active metabolites that are capable of binding to metal ions.

Rute Eliminasi

Urinary excretion plays an important role in the elimination of dexrazoxane. Forty-two percent of the 500 mg/m2 dose of dexrazoxane was excreted in the urine.

Interaksi Obat

1135 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Dexrazoxane.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Dexrazoxane.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Dexrazoxane.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Dexrazoxane.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Dexrazoxane.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Dexrazoxane.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Dexrazoxane.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Dexrazoxane.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Dexrazoxane.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Dexrazoxane.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Dexrazoxane.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Dexrazoxane.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Dexrazoxane.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Dexrazoxane.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Dexrazoxane.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Dexrazoxane.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Dexrazoxane.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Dexrazoxane.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Dexrazoxane.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Dexrazoxane.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Dexrazoxane.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Dexrazoxane.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Dexrazoxane.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Dexrazoxane.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Dexrazoxane.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Dexrazoxane.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Dexrazoxane.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Dexrazoxane.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Dexrazoxane.
Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Dexrazoxane.
Cladribine Dexrazoxane may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Dexrazoxane.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Dexrazoxane.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Dexrazoxane.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Dexrazoxane.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Dexrazoxane.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Dexrazoxane.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Dexrazoxane.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Dexrazoxane.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Dexrazoxane.
Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Dexrazoxane.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Dexrazoxane.
Vinorelbine The risk or severity of adverse effects can be increased when Vinorelbine is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Azathioprine.
Hydroxyurea The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Melphalan.
Fludarabine The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Fludarabine.

Target Protein

DNA topoisomerase 2-alpha TOP2A
DNA topoisomerase 2-beta TOP2B

Referensi & Sumber

Artikel (PubMed)

Contoh Produk & Brand

Produk: 28 • International brands: 2
Produk
  • Cardioxane
    Injection, powder, for solution • 500 mg/1 • Intravenous • US
  • Dexrazoxane
    Kit • 10 mg/1mL • Intravenous • US • Generic • Approved
  • Dexrazoxane
    Kit • 10 mg/1mL • Intravenous • US • Generic • Approved
  • Dexrazoxane
    Injection, powder, lyophilized, for solution • 500 mg/50mL • Intravenous • US • Generic • Approved
  • Dexrazoxane
    Injection, solution • 500 mg/50mL • Intravenous • US • Generic • Approved
  • Dexrazoxane
    Injection, powder, lyophilized, for solution • 500 mg/50mL • Intravenous • US • Generic • Approved
  • Dexrazoxane
    Injection, powder, lyophilized, for solution • 500 mg/50mL • Intravenous • US • Generic • Approved
  • Dexrazoxane
    Injection, powder, lyophilized, for solution • 10 mg/1mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 28 produk.
International Brands
  • Ao Nuo Xian — AosaiKang Pharmaceutical
  • Cardioxane — Novartis

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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