Peringatan Keamanan

Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.

Mexiletine

DB00379

small molecule approved investigational

Deskripsi

Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.

Struktur Molekul 2D

Berat 179.2588
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10-12 hours
Volume Distribusi * 5 to 7 L/lg
Klirens (Clearance) -

Absorpsi

Well absorbed (bioavailability 90%) from the gastrointenstinal tract.

Metabolisme

Primarily hepatic (85%) via CYP2D6 and CYP1A2 (primarily CYP2D6).

Rute Eliminasi

Approximately 10% is excreted unchanged by the kidney. The urinary excretion of N-methylmexiletine in man is less than 0.5%.

Interaksi Makanan

1 Data
  • 1. Take with food. Food reduces irritation.

Interaksi Obat

770 Data
Deferasirox The serum concentration of Mexiletine can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Mexiletine can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Mexiletine can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Mexiletine can be decreased when it is combined with Teriflunomide.
Phenytoin The serum concentration of Mexiletine can be decreased when it is combined with Phenytoin.
Fosphenytoin The serum concentration of Mexiletine can be decreased when it is combined with Fosphenytoin.
Caffeine The metabolism of Caffeine can be decreased when combined with Mexiletine.
Theophylline The metabolism of Theophylline can be decreased when combined with Mexiletine.
Dyphylline The metabolism of Dyphylline can be decreased when combined with Mexiletine.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Mexiletine.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Mexiletine.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Mexiletine.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Mexiletine.
Theobromine The metabolism of Theobromine can be decreased when combined with Mexiletine.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Mexiletine.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Mexiletine.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Mexiletine.
Xanthine The metabolism of Xanthine can be decreased when combined with Mexiletine.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Mexiletine.
Guanine The metabolism of Guanine can be decreased when combined with Mexiletine.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Mexiletine.
Peldesine The metabolism of Peldesine can be decreased when combined with Mexiletine.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Mexiletine.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Mexiletine.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Mexiletine.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Mexiletine.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Mexiletine.
Uric acid The metabolism of Uric acid can be decreased when combined with Mexiletine.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Mexiletine.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Mexiletine.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Mexiletine.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Mexiletine.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Mexiletine.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Mexiletine.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Mexiletine.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Mexiletine.
Acefylline The metabolism of Acefylline can be decreased when combined with Mexiletine.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Mexiletine.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Mexiletine.
Bufylline The metabolism of Bufylline can be decreased when combined with Mexiletine.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Mexiletine.
Furafylline The metabolism of Furafylline can be decreased when combined with Mexiletine.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Mexiletine.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Mexiletine.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Mexiletine.
Agomelatine The serum concentration of Agomelatine can be increased when it is combined with Mexiletine.
Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Mexiletine.
Mirabegron The serum concentration of Mexiletine can be increased when it is combined with Mirabegron.
Abiraterone The serum concentration of Mexiletine can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Mexiletine can be increased when combined with Cyproterone acetate.
Ibutilide Ibutilide may increase the arrhythmogenic activities of Mexiletine.
Digoxin Mexiletine may increase the arrhythmogenic activities of Digoxin.
Hyoscyamine Mexiletine may increase the arrhythmogenic activities of Hyoscyamine.
Acetyldigitoxin Mexiletine may increase the arrhythmogenic activities of Acetyldigitoxin.
Carteolol Mexiletine may increase the arrhythmogenic activities of Carteolol.
Lamotrigine Mexiletine may increase the arrhythmogenic activities of Lamotrigine.
Atropine The absorption of Mexiletine can be decreased when combined with Atropine.
Adenosine Mexiletine may increase the arrhythmogenic activities of Adenosine.
Magnesium sulfate Mexiletine may increase the arrhythmogenic activities of Magnesium sulfate.
Moricizine Mexiletine may increase the arrhythmogenic activities of Moricizine.
Levosimendan Mexiletine may increase the arrhythmogenic activities of Levosimendan.
Deslanoside Mexiletine may increase the arrhythmogenic activities of Deslanoside.
Bretylium Mexiletine may increase the arrhythmogenic activities of Bretylium.
Metipranolol Mexiletine may increase the arrhythmogenic activities of Metipranolol.
Ajmaline Mexiletine may increase the arrhythmogenic activities of Ajmaline.
Dexpropranolol Mexiletine may increase the arrhythmogenic activities of Dexpropranolol.
Azimilide Mexiletine may increase the arrhythmogenic activities of Azimilide.
Methsuximide Mexiletine may increase the arrhythmogenic activities of Methsuximide.
Tedisamil Mexiletine may increase the arrhythmogenic activities of Tedisamil.
Cariporide Mexiletine may increase the arrhythmogenic activities of Cariporide.
Xylometazoline Mexiletine may increase the arrhythmogenic activities of Xylometazoline.
Fasudil Mexiletine may increase the arrhythmogenic activities of Fasudil.
Nicorandil Mexiletine may increase the arrhythmogenic activities of Nicorandil.
Tropisetron Mexiletine may increase the arrhythmogenic activities of Tropisetron.
Simendan Mexiletine may increase the arrhythmogenic activities of Simendan.
Spiradoline Mexiletine may increase the arrhythmogenic activities of Spiradoline.
Pilsicainide Mexiletine may increase the arrhythmogenic activities of Pilsicainide.
Cicletanine Mexiletine may increase the arrhythmogenic activities of Cicletanine.
Cymarin Mexiletine may increase the arrhythmogenic activities of Cymarin.
Cibenzoline Mexiletine may increase the arrhythmogenic activities of Cibenzoline.
Metildigoxin Mexiletine may increase the arrhythmogenic activities of Metildigoxin.
Nizofenone Mexiletine may increase the arrhythmogenic activities of Nizofenone.
Prajmaline Mexiletine may increase the arrhythmogenic activities of Prajmaline.
Tiracizine Mexiletine may increase the arrhythmogenic activities of Tiracizine.
Ethacizine Mexiletine may increase the arrhythmogenic activities of Ethacizine.
Lorajmine Mexiletine may increase the arrhythmogenic activities of Lorajmine.
Bunaftine Mexiletine may increase the arrhythmogenic activities of Bunaftine.
Lorcainide Mexiletine may increase the arrhythmogenic activities of Lorcainide.
Acetyldigoxin Mexiletine may increase the arrhythmogenic activities of Acetyldigoxin.
Hydroquinine Mexiletine may increase the arrhythmogenic activities of Hydroquinine.
Bioallethrin Mexiletine may increase the arrhythmogenic activities of Bioallethrin.
Fosfructose Mexiletine may increase the arrhythmogenic activities of Fosfructose.
Fosinoprilat Mexiletine may increase the arrhythmogenic activities of Fosinoprilat.
Hydroquinidine Mexiletine may increase the arrhythmogenic activities of Hydroquinidine.
SOR-C13 Mexiletine may increase the arrhythmogenic activities of SOR-C13.
Amlodipine Mexiletine may increase the arrhythmogenic activities of Amlodipine.
Lidocaine Lidocaine may increase the arrhythmogenic activities of Mexiletine.
Betaxolol Betaxolol may increase the arrhythmogenic activities of Mexiletine.
Disopyramide Disopyramide may increase the arrhythmogenic activities of Mexiletine.
Cinnarizine Mexiletine may increase the arrhythmogenic activities of Cinnarizine.

Target Protein

Sodium channel protein type 5 subunit alpha SCN5A
Aryl hydrocarbon receptor AHR

Referensi & Sumber

Synthesis reference: Margarita Ortiz-Marciales, Kun Huang, Viatcheslav Stepanenko, Melvin De Jesus, Wildeliz Correa, "Method of synthesizing enantiopure mexiletine analogues and novel b-thiophenoxy and pyridyl ethers." U.S. Patent US08012901, issued September 06, 2011.

Contoh Produk & Brand

Produk: 75 • International brands: 17
Produk
  • Alti-mexiletine
    Capsule • 100 mg • Oral • Canada • Generic • Approved
  • Alti-mexiletine
    Capsule • 200 mg / cap • Oral • Canada • Generic • Approved
  • Mexiletine HCl
    Capsule • 150 mg/1 • Oral • US • Approved
  • Mexiletine HCl
    Capsule • 200 mg/1 • Oral • US • Approved
  • Mexiletine HCl
    Capsule • 250 mg/1 • Oral • US • Approved
  • Mexiletine Hydrochloride
    Capsule • 150 mg/1 • Oral • US • Generic • Approved
  • Mexiletine Hydrochloride
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
  • Mexiletine Hydrochloride
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 75 produk.
International Brands
  • Cirumimeru — Tsuruhara Seiyaku
  • Mekiratin — Ohara Yakuhin
  • Melate — Medisa Shinyaku
  • Meldest — Taiyo Pharmaceutical
  • Meletin — Taiwan Biotech
  • Mequitolide — Towa Yakuhin
  • Metorekicin — Choseido Pharmaceutical
  • Mexicord — Polfa Grodzisk
  • Mexitilen — Boehringer Ingelheim
  • Minsetil — Zdravlje

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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