No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route.
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ulipristal | The therapeutic efficacy of Dydrogesterone can be decreased when used in combination with Ulipristal. |
| Lepirudin | Dydrogesterone may decrease the anticoagulant activities of Lepirudin. |
| Bivalirudin | Dydrogesterone may decrease the anticoagulant activities of Bivalirudin. |
| Alteplase | Dydrogesterone may decrease the anticoagulant activities of Alteplase. |
| Urokinase | Dydrogesterone may decrease the anticoagulant activities of Urokinase. |
| Reteplase | Dydrogesterone may decrease the anticoagulant activities of Reteplase. |
| Anistreplase | Dydrogesterone may decrease the anticoagulant activities of Anistreplase. |
| Tenecteplase | Dydrogesterone may decrease the anticoagulant activities of Tenecteplase. |
| Abciximab | Dydrogesterone may decrease the anticoagulant activities of Abciximab. |
| Drotrecogin alfa | Dydrogesterone may decrease the anticoagulant activities of Drotrecogin alfa. |
| Streptokinase | Dydrogesterone may decrease the anticoagulant activities of Streptokinase. |
| Dicoumarol | Dydrogesterone may decrease the anticoagulant activities of Dicoumarol. |
| Ardeparin | Dydrogesterone may decrease the anticoagulant activities of Ardeparin. |
| Phenindione | Dydrogesterone may decrease the anticoagulant activities of Phenindione. |
| Fondaparinux | Dydrogesterone may decrease the anticoagulant activities of Fondaparinux. |
| Pentosan polysulfate | Dydrogesterone may decrease the anticoagulant activities of Pentosan polysulfate. |
| Dipyridamole | Dydrogesterone may decrease the anticoagulant activities of Dipyridamole. |
| Heparin | Dydrogesterone may decrease the anticoagulant activities of Heparin. |
| Enoxaparin | Dydrogesterone may decrease the anticoagulant activities of Enoxaparin. |
| Epoprostenol | Dydrogesterone may decrease the anticoagulant activities of Epoprostenol. |
| Coumarin | Dydrogesterone may decrease the anticoagulant activities of Coumarin. |
| Ximelagatran | Dydrogesterone may decrease the anticoagulant activities of Ximelagatran. |
| Desmoteplase | Dydrogesterone may decrease the anticoagulant activities of Desmoteplase. |
| Defibrotide | Dydrogesterone may decrease the anticoagulant activities of Defibrotide. |
| Ancrod | Dydrogesterone may decrease the anticoagulant activities of Ancrod. |
| Beraprost | Dydrogesterone may decrease the anticoagulant activities of Beraprost. |
| Prasugrel | Dydrogesterone may decrease the anticoagulant activities of Prasugrel. |
| Sulodexide | Dydrogesterone may decrease the anticoagulant activities of Sulodexide. |
| Semuloparin | Dydrogesterone may decrease the anticoagulant activities of Semuloparin. |
| Idraparinux | Dydrogesterone may decrease the anticoagulant activities of Idraparinux. |
| Cangrelor | Dydrogesterone may decrease the anticoagulant activities of Cangrelor. |
| Astaxanthin | Dydrogesterone may decrease the anticoagulant activities of Astaxanthin. |
| Apixaban | Dydrogesterone may decrease the anticoagulant activities of Apixaban. |
| Otamixaban | Dydrogesterone may decrease the anticoagulant activities of Otamixaban. |
| Amediplase | Dydrogesterone may decrease the anticoagulant activities of Amediplase. |
| Dabigatran etexilate | Dydrogesterone may decrease the anticoagulant activities of Dabigatran etexilate. |
| Danaparoid | Dydrogesterone may decrease the anticoagulant activities of Danaparoid. |
| Dalteparin | Dydrogesterone may decrease the anticoagulant activities of Dalteparin. |
| Tinzaparin | Dydrogesterone may decrease the anticoagulant activities of Tinzaparin. |
| (R)-warfarin | Dydrogesterone may decrease the anticoagulant activities of (R)-warfarin. |
| Nadroparin | Dydrogesterone may decrease the anticoagulant activities of Nadroparin. |
| Triflusal | Dydrogesterone may decrease the anticoagulant activities of Triflusal. |
| Ditazole | Dydrogesterone may decrease the anticoagulant activities of Ditazole. |
| Vorapaxar | Dydrogesterone may decrease the anticoagulant activities of Vorapaxar. |
| Edoxaban | Dydrogesterone may decrease the anticoagulant activities of Edoxaban. |
| Sodium citrate | Dydrogesterone may decrease the anticoagulant activities of Sodium citrate. |
| Dextran | Dydrogesterone may decrease the anticoagulant activities of Dextran. |
| Bemiparin | Dydrogesterone may decrease the anticoagulant activities of Bemiparin. |
| Parnaparin | Dydrogesterone may decrease the anticoagulant activities of Parnaparin. |
| Desirudin | Dydrogesterone may decrease the anticoagulant activities of Desirudin. |
| Antithrombin Alfa | Dydrogesterone may decrease the anticoagulant activities of Antithrombin Alfa. |
| Protein C | Dydrogesterone may decrease the anticoagulant activities of Protein C. |
| Antithrombin III human | Dydrogesterone may decrease the anticoagulant activities of Antithrombin III human. |
| Letaxaban | Dydrogesterone may decrease the anticoagulant activities of Letaxaban. |
| Darexaban | Dydrogesterone may decrease the anticoagulant activities of Darexaban. |
| Betrixaban | Dydrogesterone may decrease the anticoagulant activities of Betrixaban. |
| Nafamostat | Dydrogesterone may decrease the anticoagulant activities of Nafamostat. |
| Monteplase | Dydrogesterone may decrease the anticoagulant activities of Monteplase. |
| Gabexate | Dydrogesterone may decrease the anticoagulant activities of Gabexate. |
| Protein S human | Dydrogesterone may decrease the anticoagulant activities of Protein S human. |
| Brinase | Dydrogesterone may decrease the anticoagulant activities of Brinase. |
| Tioclomarol | Dydrogesterone may decrease the anticoagulant activities of Tioclomarol. |
| Melagatran | Dydrogesterone may decrease the anticoagulant activities of Melagatran. |
| Saruplase | Dydrogesterone may decrease the anticoagulant activities of Saruplase. |
| (S)-Warfarin | Dydrogesterone may decrease the anticoagulant activities of (S)-Warfarin. |
| Tocopherylquinone | Dydrogesterone may decrease the anticoagulant activities of Tocopherylquinone. |
| Dabigatran | Dydrogesterone may decrease the anticoagulant activities of Dabigatran. |
| Argatroban | Dydrogesterone may decrease the anticoagulant activities of Argatroban. |
| Warfarin | Dydrogesterone may decrease the anticoagulant activities of Warfarin. |
| Phenprocoumon | Dydrogesterone may decrease the anticoagulant activities of Phenprocoumon. |
| Acenocoumarol | Dydrogesterone may decrease the anticoagulant activities of Acenocoumarol. |
| 4-hydroxycoumarin | Dydrogesterone may decrease the anticoagulant activities of 4-hydroxycoumarin. |
| Rivaroxaban | Dydrogesterone may decrease the anticoagulant activities of Rivaroxaban. |
| Ethyl biscoumacetate | Dydrogesterone may decrease the anticoagulant activities of Ethyl biscoumacetate. |
| Ticagrelor | Dydrogesterone may decrease the anticoagulant activities of Ticagrelor. |
| Fluindione | Dydrogesterone may decrease the anticoagulant activities of Fluindione. |
| Clorindione | Dydrogesterone may decrease the anticoagulant activities of Clorindione. |
| Diphenadione | Dydrogesterone may decrease the anticoagulant activities of Diphenadione. |
| Troxerutin | Dydrogesterone may decrease the anticoagulant activities of Troxerutin. |
| Edetic acid | Dydrogesterone may decrease the anticoagulant activities of Edetic acid. |
| Reviparin | Dydrogesterone may decrease the anticoagulant activities of Reviparin. |
| Dermatan sulfate | Dydrogesterone may decrease the anticoagulant activities of Dermatan sulfate. |
| SR-123781A | Dydrogesterone may decrease the anticoagulant activities of SR-123781A. |
| Human C1-esterase inhibitor | The risk or severity of thromboembolism can be increased when Dydrogesterone is combined with Human C1-esterase inhibitor. |
| Conestat alfa | The risk or severity of thromboembolism can be increased when Dydrogesterone is combined with Conestat alfa. |
| Lymecycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Lymecycline. |
| Clomocycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Clomocycline. |
| Tigecycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Tigecycline. |
| Oxytetracycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Oxytetracycline. |
| Demeclocycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Demeclocycline. |
| Metacycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Metacycline. |
| Minocycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Minocycline. |
| Rolitetracycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Rolitetracycline. |
| Sarecycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Sarecycline. |
| Omadacycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Omadacycline. |
| Penimepicycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Penimepicycline. |
| Doxycycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Doxycycline. |
| Tetracycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Tetracycline. |
| Eravacycline | The serum concentration of Dydrogesterone can be decreased when it is combined with Eravacycline. |
| Pitolisant | The serum concentration of Dydrogesterone can be decreased when it is combined with Pitolisant. |