Peringatan Keamanan

In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.

Norepinephrine

DB00368

small molecule approved

Deskripsi

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Struktur Molekul 2D

Berat 169.1778
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1008 Data
Valsartan Norepinephrine may decrease the antihypertensive activities of Valsartan.
Ramipril Norepinephrine may decrease the antihypertensive activities of Ramipril.
Remikiren Norepinephrine may decrease the antihypertensive activities of Remikiren.
Isradipine Norepinephrine may decrease the antihypertensive activities of Isradipine.
Olmesartan Norepinephrine may decrease the antihypertensive activities of Olmesartan.
Nitroprusside Norepinephrine may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Norepinephrine may decrease the antihypertensive activities of Diltiazem.
Minoxidil Norepinephrine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Norepinephrine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Norepinephrine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Norepinephrine may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Norepinephrine may decrease the antihypertensive activities of Nisoldipine.
Fosinopril Norepinephrine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Norepinephrine may decrease the antihypertensive activities of Trandolapril.
Lercanidipine Norepinephrine may decrease the antihypertensive activities of Lercanidipine.
Benazepril Norepinephrine may decrease the antihypertensive activities of Benazepril.
Bosentan Norepinephrine may decrease the antihypertensive activities of Bosentan.
Enalapril Norepinephrine may decrease the antihypertensive activities of Enalapril.
Candoxatril Norepinephrine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Norepinephrine may decrease the antihypertensive activities of Mecamylamine.
Losartan Norepinephrine may decrease the antihypertensive activities of Losartan.
Moexipril Norepinephrine may decrease the antihypertensive activities of Moexipril.
Lisinopril Norepinephrine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Norepinephrine may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Norepinephrine may decrease the antihypertensive activities of Metyrosine.
Cryptenamine Norepinephrine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Norepinephrine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Norepinephrine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Norepinephrine may decrease the antihypertensive activities of Fenoldopam.
Tadalafil Norepinephrine may decrease the antihypertensive activities of Tadalafil.
Eprosartan Norepinephrine may decrease the antihypertensive activities of Eprosartan.
Quinapril Norepinephrine may decrease the antihypertensive activities of Quinapril.
Telmisartan Norepinephrine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Norepinephrine may decrease the antihypertensive activities of Methyldopa.
Irbesartan Norepinephrine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Norepinephrine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Norepinephrine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Norepinephrine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Norepinephrine may decrease the antihypertensive activities of Trimethaphan.
Captopril Norepinephrine may decrease the antihypertensive activities of Captopril.
Epoprostenol Norepinephrine may decrease the antihypertensive activities of Epoprostenol.
Bepridil Norepinephrine may decrease the antihypertensive activities of Bepridil.
Hydralazine Norepinephrine may decrease the antihypertensive activities of Hydralazine.
Cilazapril Norepinephrine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Norepinephrine may decrease the antihypertensive activities of Saprisartan.
Spirapril Norepinephrine may decrease the antihypertensive activities of Spirapril.
Mibefradil Norepinephrine may decrease the antihypertensive activities of Mibefradil.
Debrisoquine Norepinephrine may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Norepinephrine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Norepinephrine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Norepinephrine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Norepinephrine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Norepinephrine may decrease the antihypertensive activities of Pinacidil.
Temocapril Norepinephrine may decrease the antihypertensive activities of Temocapril.
Riociguat Norepinephrine may decrease the antihypertensive activities of Riociguat.
Macitentan Norepinephrine may decrease the antihypertensive activities of Macitentan.
Hexamethonium Norepinephrine may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Norepinephrine may decrease the antihypertensive activities of Aliskiren.
Nicorandil Norepinephrine may decrease the antihypertensive activities of Nicorandil.
Lacidipine Norepinephrine may decrease the antihypertensive activities of Lacidipine.
Manidipine Norepinephrine may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Norepinephrine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Norepinephrine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Norepinephrine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Norepinephrine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Norepinephrine may decrease the antihypertensive activities of Imidapril.
BQ-123 Norepinephrine may decrease the antihypertensive activities of BQ-123.
Tetrahydropalmatine Norepinephrine may decrease the antihypertensive activities of Tetrahydropalmatine.
Dihydralazine Norepinephrine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Norepinephrine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Norepinephrine may decrease the antihypertensive activities of Guanoxan.
Delapril Norepinephrine may decrease the antihypertensive activities of Delapril.
Vincamine Norepinephrine may decrease the antihypertensive activities of Vincamine.
Linsidomine Norepinephrine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Norepinephrine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Norepinephrine may decrease the antihypertensive activities of Tolonidine.
Endralazine Norepinephrine may decrease the antihypertensive activities of Endralazine.
Cadralazine Norepinephrine may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Norepinephrine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Norepinephrine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Norepinephrine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Norepinephrine may decrease the antihypertensive activities of Guanoclor.
Candesartan Norepinephrine may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Norepinephrine may decrease the antihypertensive activities of Dexniguldipine.
Tocopherylquinone Norepinephrine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Norepinephrine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Norepinephrine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Norepinephrine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Norepinephrine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Norepinephrine may decrease the antihypertensive activities of Quinaprilat.
Felodipine Norepinephrine may decrease the antihypertensive activities of Felodipine.
Levamlodipine Norepinephrine may decrease the antihypertensive activities of Levamlodipine.
Azilsartan medoxomil Norepinephrine may decrease the antihypertensive activities of Azilsartan medoxomil.
Diazoxide Norepinephrine may decrease the antihypertensive activities of Diazoxide.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Norepinephrine.
Benzylpenicilloyl polylysine Norepinephrine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Norepinephrine.
Cyclosporine The risk or severity of hypertension can be increased when Cyclosporine is combined with Norepinephrine.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Norepinephrine.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Norepinephrine.

Target Protein

Alpha-1A adrenergic receptor ADRA1A
Alpha-1B adrenergic receptor ADRA1B
Alpha-1D adrenergic receptor ADRA1D
Alpha-2A adrenergic receptor ADRA2A
Alpha-2B adrenergic receptor ADRA2B
Alpha-2C adrenergic receptor ADRA2C
Beta-1 adrenergic receptor ADRB1
Beta-2 adrenergic receptor ADRB2
Beta-3 adrenergic receptor ADRB3
Phenylalanine-4-hydroxylase PAH
Synaptic vesicular amine transporter SLC18A2
Chromaffin granule amine transporter SLC18A1

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 60 • International brands: 0
Produk
  • Levophed
    Injection, solution, concentrate • 1 mg/1mL • Intravenous • US • Approved
  • Levophed
    Injection, solution, concentrate • 1 mg/1mL • Intravenous • US • Approved
  • Levophed
    Injection, solution, concentrate • 1 mg/1mL • Intravenous • US • Approved
  • Levophed
    Injection, solution, concentrate • 1 mg/1mL • Intravenous • US • Approved
  • Levophed
    Solution • 1 mg / mL • Intravenous • Canada • Approved
  • Levophed
    Injection, solution, concentrate • 1 mg/1mL • Intravenous • US • Approved
  • Levophed Liq IV 1.0mg/ml
    Liquid • 1 mg / mL • Intravenous • Canada • Approved
  • Levophed(r) Norepinephrine Bitartrate
    Injection, solution, concentrate • 1 mg/1mL • Intravenous • US • Approved
Menampilkan 8 dari 60 produk.

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