Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Sapropterin. |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Sapropterin. |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Sapropterin. |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Sapropterin. |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Sapropterin. |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Sapropterin. |
| Naloxegol | The serum concentration of Naloxegol can be increased when it is combined with Sapropterin. |
| Pazopanib | The serum concentration of Pazopanib can be increased when it is combined with Sapropterin. |
| Prucalopride | The serum concentration of Prucalopride can be increased when it is combined with Sapropterin. |
| Ranolazine | The serum concentration of Ranolazine can be increased when it is combined with Sapropterin. |
| Silodosin | The excretion of Silodosin can be decreased when combined with Sapropterin. |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Sapropterin. |
| Everolimus | The serum concentration of Everolimus can be increased when it is combined with Sapropterin. |
| Rifaximin | The serum concentration of Rifaximin can be increased when it is combined with Sapropterin. |
| Levodopa | The risk or severity of adverse effects can be increased when Sapropterin is combined with Levodopa. |
| Methotrexate | The serum concentration of Sapropterin can be decreased when it is combined with Methotrexate. |
| Pralatrexate | The serum concentration of Sapropterin can be decreased when it is combined with Pralatrexate. |
| Sildenafil | Sapropterin may increase the hypotensive activities of Sildenafil. |
| Tadalafil | Sapropterin may increase the hypotensive activities of Tadalafil. |
| Vardenafil | Sapropterin may increase the hypotensive activities of Vardenafil. |
| Udenafil | Sapropterin may increase the hypotensive activities of Udenafil. |
| Mirodenafil | Sapropterin may increase the hypotensive activities of Mirodenafil. |
| Avanafil | Sapropterin may increase the hypotensive activities of Avanafil. |
| Dipyridamole | Sapropterin may increase the hypotensive activities of Dipyridamole. |
| Fostamatinib | Sapropterin may increase the hypotensive activities of Fostamatinib. |
| Ibudilast | Sapropterin may increase the hypotensive activities of Ibudilast. |
| Doxofylline | Sapropterin may increase the hypotensive activities of Doxofylline. |
| Vincristine | The excretion of Vincristine can be decreased when combined with Sapropterin. |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Sapropterin. |
| Betrixaban | The serum concentration of Betrixaban can be increased when it is combined with Sapropterin. |
| Daptomycin | The serum concentration of Daptomycin can be increased when it is combined with Sapropterin. |
| Pravastatin | The serum concentration of Pravastatin can be increased when it is combined with Sapropterin. |
| Morphine | The serum concentration of Morphine can be increased when it is combined with Sapropterin. |
| Tenofovir disoproxil | The serum concentration of Tenofovir disoproxil can be increased when it is combined with Sapropterin. |
| Clobazam | The serum concentration of Clobazam can be increased when it is combined with Sapropterin. |
| Mefloquine | The serum concentration of Mefloquine can be increased when it is combined with Sapropterin. |
| Quinine | The serum concentration of Quinine can be increased when it is combined with Sapropterin. |
| Toremifene | The serum concentration of Toremifene can be increased when it is combined with Sapropterin. |
| Bisoprolol | The serum concentration of Bisoprolol can be increased when it is combined with Sapropterin. |
| Simvastatin | The serum concentration of Simvastatin can be increased when it is combined with Sapropterin. |
| Mannitol | The serum concentration of Mannitol can be increased when it is combined with Sapropterin. |
| Loperamide | The excretion of Loperamide can be decreased when combined with Sapropterin. |
| Clomifene | The serum concentration of Clomifene can be increased when it is combined with Sapropterin. |
| Tipranavir | The serum concentration of Tipranavir can be increased when it is combined with Sapropterin. |
| Fexofenadine | The serum concentration of Fexofenadine can be increased when it is combined with Sapropterin. |
| Tegaserod | The serum concentration of Tegaserod can be increased when it is combined with Sapropterin. |
| Saquinavir | The serum concentration of Saquinavir can be increased when it is combined with Sapropterin. |
| Sitagliptin | The serum concentration of Sitagliptin can be increased when it is combined with Sapropterin. |
| Posaconazole | The serum concentration of Posaconazole can be increased when it is combined with Sapropterin. |
| Darunavir | The serum concentration of Darunavir can be increased when it is combined with Sapropterin. |
| Paliperidone | The serum concentration of Paliperidone can be increased when it is combined with Sapropterin. |
| Mibefradil | The serum concentration of Mibefradil can be increased when it is combined with Sapropterin. |
| Belinostat | The serum concentration of Belinostat can be increased when it is combined with Sapropterin. |
| Indacaterol | The serum concentration of Indacaterol can be increased when it is combined with Sapropterin. |
| Telaprevir | The serum concentration of Telaprevir can be increased when it is combined with Sapropterin. |
| Rivaroxaban | The serum concentration of Rivaroxaban can be increased when it is combined with Sapropterin. |
| Simeprevir | The serum concentration of Simeprevir can be increased when it is combined with Sapropterin. |
| Ambrisentan | The serum concentration of Ambrisentan can be increased when it is combined with Sapropterin. |
| Cethromycin | The serum concentration of Cethromycin can be increased when it is combined with Sapropterin. |
| Apixaban | The serum concentration of Apixaban can be increased when it is combined with Sapropterin. |
| Odanacatib | The serum concentration of Odanacatib can be increased when it is combined with Sapropterin. |
| Ticagrelor | The serum concentration of Ticagrelor can be increased when it is combined with Sapropterin. |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Sapropterin. |
| Mirabegron | The serum concentration of Mirabegron can be increased when it is combined with Sapropterin. |
| Canagliflozin | The serum concentration of Canagliflozin can be increased when it is combined with Sapropterin. |
| Dolutegravir | The serum concentration of Dolutegravir can be increased when it is combined with Sapropterin. |
| Sofosbuvir | The serum concentration of Sofosbuvir can be increased when it is combined with Sapropterin. |
| Idelalisib | The serum concentration of Idelalisib can be increased when it is combined with Sapropterin. |
| Umeclidinium | The serum concentration of Umeclidinium can be increased when it is combined with Sapropterin. |
| Lenvatinib | The serum concentration of Lenvatinib can be increased when it is combined with Sapropterin. |
| Nintedanib | The serum concentration of Nintedanib can be increased when it is combined with Sapropterin. |
| Technetium Tc-99m sestamibi | The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sapropterin. |
| Dasabuvir | The serum concentration of Dasabuvir can be increased when it is combined with Sapropterin. |
| Methylene blue | The serum concentration of Methylene blue can be increased when it is combined with Sapropterin. |
| Ombitasvir | The serum concentration of Ombitasvir can be increased when it is combined with Sapropterin. |
| Paritaprevir | The serum concentration of Paritaprevir can be increased when it is combined with Sapropterin. |
| Selexipag | The serum concentration of Selexipag can be increased when it is combined with Sapropterin. |
| Elbasvir | The serum concentration of Elbasvir can be increased when it is combined with Sapropterin. |
| Grazoprevir | The serum concentration of Grazoprevir can be increased when it is combined with Sapropterin. |
| Velpatasvir | The serum concentration of Velpatasvir can be increased when it is combined with Sapropterin. |
| Tucatinib | The serum concentration of Tucatinib can be increased when it is combined with Sapropterin. |
| Selumetinib | The serum concentration of Selumetinib can be increased when it is combined with Sapropterin. |
| Voclosporin | The serum concentration of Voclosporin can be increased when it is combined with Sapropterin. |
| Tezacaftor | The serum concentration of Tezacaftor can be increased when it is combined with Sapropterin. |
| Lasmiditan | The serum concentration of Lasmiditan can be increased when it is combined with Sapropterin. |
| Talinolol | The serum concentration of Talinolol can be increased when it is combined with Sapropterin. |
| Fostemsavir | The serum concentration of Fostemsavir can be increased when it is combined with Sapropterin. |
| Revefenacin | The serum concentration of Revefenacin can be increased when it is combined with Sapropterin. |
| Valspodar | The serum concentration of Valspodar can be increased when it is combined with Sapropterin. |
| Lemborexant | The serum concentration of Lemborexant can be increased when it is combined with Sapropterin. |
| Duvelisib | The serum concentration of Duvelisib can be increased when it is combined with Sapropterin. |
| Glasdegib | The serum concentration of Glasdegib can be increased when it is combined with Sapropterin. |
| Elagolix | The serum concentration of Elagolix can be increased when it is combined with Sapropterin. |
| Voxilaprevir | The serum concentration of Voxilaprevir can be increased when it is combined with Sapropterin. |
| Gilteritinib | The serum concentration of Gilteritinib can be increased when it is combined with Sapropterin. |
| Omadacycline | The serum concentration of Omadacycline can be increased when it is combined with Sapropterin. |
| Fedratinib | The serum concentration of Fedratinib can be increased when it is combined with Sapropterin. |
| Grapiprant | The serum concentration of Grapiprant can be increased when it is combined with Sapropterin. |
| Tazemetostat | The serum concentration of Tazemetostat can be increased when it is combined with Sapropterin. |
| Darolutamide | The serum concentration of Darolutamide can be increased when it is combined with Sapropterin. |