Peringatan Keamanan

Oral LD50 in mouse is 1500 mg/kg.

Sulfadiazine

DB00359

small molecule approved investigational vet_approved

Deskripsi

One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Struktur Molekul 2D

Berat 250.277
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Sulfadiazine is excreted largely in the urine.

Interaksi Obat

1483 Data
Pegvisomant The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Sulfadiazine.
Nicotine The risk or severity of adverse effects can be increased when Sulfadiazine is combined with Nicotine.
Mecamylamine The risk or severity of adverse effects can be increased when Sulfadiazine is combined with Mecamylamine.
Pentolinium The risk or severity of adverse effects can be increased when Sulfadiazine is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Sulfadiazine is combined with Trimethaphan.
Hexamethonium The risk or severity of adverse effects can be increased when Sulfadiazine is combined with Hexamethonium.
Cyclopentamine The risk or severity of adverse effects can be increased when Sulfadiazine is combined with Cyclopentamine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Sulfadiazine is combined with Prilocaine.
Methotrexate The protein binding of Methotrexate can be increased when combined with Sulfadiazine.
Mifepristone The serum concentration of Sulfadiazine can be increased when it is combined with Mifepristone.
Lipoic acid The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Sulfadiazine.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfadiazine.
Moxifloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Moxifloxacin.
Grepafloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Grepafloxacin.
Enoxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Enoxacin.
Pefloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Pefloxacin.
Ciprofloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Ciprofloxacin.
Trovafloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Trovafloxacin.
Nalidixic acid The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Nalidixic acid.
Rosoxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Rosoxacin.
Cinoxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Cinoxacin.
Lomefloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Lomefloxacin.
Gatifloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Gatifloxacin.
Norfloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Norfloxacin.
Levofloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Levofloxacin.
Gemifloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Gemifloxacin.
Ofloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Ofloxacin.
Sparfloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Sparfloxacin.
Temafloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Temafloxacin.
Fleroxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Fleroxacin.
Technetium Tc-99m ciprofloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Technetium Tc-99m ciprofloxacin.
Garenoxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Garenoxacin.
Nemonoxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Nemonoxacin.
Flumequine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Flumequine.
Enrofloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Enrofloxacin.
Orbifloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Orbifloxacin.
Sarafloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Sarafloxacin.
Difloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Difloxacin.
Pazufloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Pazufloxacin.
Prulifloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Prulifloxacin.
Delafloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Delafloxacin.
Sitafloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Sitafloxacin.
Oxolinic acid The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Oxolinic acid.
Rufloxacin The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Rufloxacin.
Pipemidic acid The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Pipemidic acid.
Methyclothiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Methyclothiazide.
Chlorthalidone The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Chlorthalidone.
Bendroflumethiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Bendroflumethiazide.
Metolazone The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Metolazone.
Benzthiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Benzthiazide.
Hydroflumethiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Hydroflumethiazide.
Indapamide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Indapamide.
Chlorothiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Chlorothiazide.
Hydrochlorothiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Hydrochlorothiazide.
Trichlormethiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Trichlormethiazide.
Polythiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Polythiazide.
Quinethazone The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Quinethazone.
Cyclopenthiazide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Cyclopenthiazide.
Epitizide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Epitizide.
Protriptyline Protriptyline may decrease the hypoglycemic activities of Sulfadiazine.
Amoxapine Amoxapine may decrease the hypoglycemic activities of Sulfadiazine.
Amineptine Amineptine may decrease the hypoglycemic activities of Sulfadiazine.
Butriptyline Butriptyline may decrease the hypoglycemic activities of Sulfadiazine.
Dosulepin Dosulepin may decrease the hypoglycemic activities of Sulfadiazine.
Oxaprotiline Oxaprotiline may decrease the hypoglycemic activities of Sulfadiazine.
Opipramol Opipramol may decrease the hypoglycemic activities of Sulfadiazine.
Amitriptylinoxide Amitriptylinoxide may decrease the hypoglycemic activities of Sulfadiazine.
Dibenzepin Dibenzepin may decrease the hypoglycemic activities of Sulfadiazine.
Quinupramine Quinupramine may decrease the hypoglycemic activities of Sulfadiazine.
Melitracen Melitracen may decrease the hypoglycemic activities of Sulfadiazine.
Lofepramine Lofepramine may decrease the hypoglycemic activities of Sulfadiazine.
Iprindole Iprindole may decrease the hypoglycemic activities of Sulfadiazine.
Imipramine oxide Imipramine oxide may decrease the hypoglycemic activities of Sulfadiazine.
Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Sulfadiazine.
Tianeptine Tianeptine may decrease the hypoglycemic activities of Sulfadiazine.
Imipramine Imipramine may decrease the hypoglycemic activities of Sulfadiazine.
Desipramine Desipramine may decrease the hypoglycemic activities of Sulfadiazine.
Clomipramine Clomipramine may decrease the hypoglycemic activities of Sulfadiazine.
Dimetacrine Dimetacrine may decrease the hypoglycemic activities of Sulfadiazine.
Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Sulfadiazine.
Dexketoprofen The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfadiazine.
Dapsone The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Sulfadiazine.
Cyclosporine The risk or severity of renal failure can be increased when Sulfadiazine is combined with Cyclosporine.
Methenamine Methenamine can cause a decrease in the absorption of Sulfadiazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Canagliflozin Canagliflozin may increase the hypoglycemic activities of Sulfadiazine.
Leuprolide The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Leuprolide.
Goserelin The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Goserelin.
Ziprasidone The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Ziprasidone.
Etonogestrel The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Etonogestrel.
Desogestrel The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Desogestrel.
Olanzapine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Olanzapine.
Megestrol acetate The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Megestrol acetate.
Clozapine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Clozapine.
Levonorgestrel The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Levonorgestrel.
Progesterone The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Progesterone.
Chlorpromazine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Chlorpromazine.
Piperazine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Piperazine.
Niacin The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Niacin.
Epinephrine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Epinephrine.
Norethisterone The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Norethisterone.

Target Protein

Dihydropteroate synthetase
Dihydropteroate synthase folP

Referensi & Sumber

Synthesis reference: Charles L. Fox, Jr., Shanta M. Modak, Paul Fox, "Wound dressing comprising silver sulfadiazine incorporated in animal tissue and method of preparation." U.S. Patent US4599226, issued September, 1977.

Contoh Produk & Brand

Produk: 14 • International brands: 1
Produk
  • Coptin Oral Suspension
    Suspension • - • Oral • Canada • Approved
  • Coptin Tab
    Tablet • - • Oral • Canada • Approved
  • Coptin Tab
    Tablet • - • Oral • Canada • Approved
  • Ovoquinol Cones
    Suppository • - • Vaginal • Canada • Approved
  • Ovoquinol Crm Vaginale
    Cream • - • Vaginal • Canada • Approved
  • Sulfadiazine
    Tablet • 500 mg/1 • Oral • US • Generic • Approved
  • Sulfadiazine
    Tablet • 500 mg/1 • Oral • US • Generic • Approved
  • Sulfadiazine
    Powder • 1 g/1g • Not applicable • US
Menampilkan 8 dari 14 produk.
International Brands
  • Adiazine

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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