Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Aminoglutethimide. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Aminoglutethimide. |
| Ifosfamide | The metabolism of Ifosfamide can be increased when combined with Aminoglutethimide. |
| Perampanel | The metabolism of Perampanel can be increased when combined with Aminoglutethimide. |
| Warfarin | The metabolism of Warfarin can be increased when combined with Aminoglutethimide. |
| Acenocoumarol | The metabolism of Acenocoumarol can be increased when combined with Aminoglutethimide. |
| (R)-warfarin | The metabolism of (R)-warfarin can be increased when combined with Aminoglutethimide. |
| R,S-Warfarin alcohol | The metabolism of R,S-Warfarin alcohol can be increased when combined with Aminoglutethimide. |
| S,R-Warfarin alcohol | The metabolism of S,R-Warfarin alcohol can be increased when combined with Aminoglutethimide. |
| (S)-Warfarin | The metabolism of (S)-Warfarin can be increased when combined with Aminoglutethimide. |
| Methadone | The serum concentration of Methadone can be increased when it is combined with Aminoglutethimide. |
| Erlotinib | The serum concentration of Erlotinib can be decreased when it is combined with Aminoglutethimide. |
| Segesterone acetate | The metabolism of Segesterone acetate can be increased when combined with Aminoglutethimide. |
| Diethylstilbestrol | The metabolism of Diethylstilbestrol can be increased when combined with Aminoglutethimide. |
| Etonogestrel | The metabolism of Etonogestrel can be increased when combined with Aminoglutethimide. |
| Desogestrel | The metabolism of Desogestrel can be increased when combined with Aminoglutethimide. |
| Megestrol acetate | The metabolism of Megestrol acetate can be increased when combined with Aminoglutethimide. |
| Levonorgestrel | The metabolism of Levonorgestrel can be increased when combined with Aminoglutethimide. |
| Progesterone | The metabolism of Progesterone can be increased when combined with Aminoglutethimide. |
| Norethisterone | The metabolism of Norethisterone can be increased when combined with Aminoglutethimide. |
| Estradiol | The metabolism of Estradiol can be increased when combined with Aminoglutethimide. |
| Ethynodiol diacetate | The metabolism of Ethynodiol diacetate can be increased when combined with Aminoglutethimide. |
| Mifepristone | The metabolism of Mifepristone can be increased when combined with Aminoglutethimide. |
| Norgestimate | The metabolism of Norgestimate can be increased when combined with Aminoglutethimide. |
| Ethinylestradiol | The metabolism of Ethinylestradiol can be increased when combined with Aminoglutethimide. |
| Mestranol | The metabolism of Mestranol can be increased when combined with Aminoglutethimide. |
| Drospirenone | The metabolism of Drospirenone can be increased when combined with Aminoglutethimide. |
| Estrone sulfate | The metabolism of Estrone sulfate can be increased when combined with Aminoglutethimide. |
| Octylphenoxy polyethoxyethanol | The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Aminoglutethimide. |
| Cyproterone acetate | The metabolism of Cyproterone acetate can be increased when combined with Aminoglutethimide. |
| Trestolone | The metabolism of Trestolone can be increased when combined with Aminoglutethimide. |
| Norelgestromin | The metabolism of Norelgestromin can be increased when combined with Aminoglutethimide. |
| Gestodene | The metabolism of Gestodene can be increased when combined with Aminoglutethimide. |
| Hydroxyprogesterone caproate | The metabolism of Hydroxyprogesterone caproate can be increased when combined with Aminoglutethimide. |
| Dienogest | The metabolism of Dienogest can be increased when combined with Aminoglutethimide. |
| Norethynodrel | The metabolism of Norethynodrel can be increased when combined with Aminoglutethimide. |
| Norgestrel | The metabolism of Norgestrel can be increased when combined with Aminoglutethimide. |
| Cloprostenol | The metabolism of Cloprostenol can be increased when combined with Aminoglutethimide. |
| Gestrinone | The metabolism of Gestrinone can be increased when combined with Aminoglutethimide. |
| Nomegestrol | The metabolism of Nomegestrol can be increased when combined with Aminoglutethimide. |
| Lynestrenol | The metabolism of Lynestrenol can be increased when combined with Aminoglutethimide. |
| Gossypol | The metabolism of Gossypol can be increased when combined with Aminoglutethimide. |
| Ormeloxifene | The metabolism of Ormeloxifene can be increased when combined with Aminoglutethimide. |
| Chlormadinone | The metabolism of Chlormadinone can be increased when combined with Aminoglutethimide. |
| Norgestrienone | The metabolism of Norgestrienone can be increased when combined with Aminoglutethimide. |
| Quingestanol | The metabolism of Quingestanol can be increased when combined with Aminoglutethimide. |
| Demegestone | The metabolism of Demegestone can be increased when combined with Aminoglutethimide. |
| Etynodiol | The metabolism of Etynodiol can be increased when combined with Aminoglutethimide. |
| Testosterone enanthate | The metabolism of Testosterone enanthate can be increased when combined with Aminoglutethimide. |
| Estradiol benzoate | The metabolism of Estradiol benzoate can be increased when combined with Aminoglutethimide. |
| Estradiol cypionate | The metabolism of Estradiol cypionate can be increased when combined with Aminoglutethimide. |
| Estradiol valerate | The metabolism of Estradiol valerate can be increased when combined with Aminoglutethimide. |
| Nomegestrol acetate | The metabolism of Nomegestrol acetate can be increased when combined with Aminoglutethimide. |
| Norethindrone enanthate | The metabolism of Norethindrone enanthate can be increased when combined with Aminoglutethimide. |
| Ulipristal | The metabolism of Ulipristal can be increased when combined with Aminoglutethimide. |
| Azithromycin | The metabolism of Azithromycin can be increased when combined with Aminoglutethimide. |
| Ziprasidone | The metabolism of Ziprasidone can be increased when combined with Aminoglutethimide. |
| Chlorpromazine | The metabolism of Chlorpromazine can be increased when combined with Aminoglutethimide. |
| Albendazole | The metabolism of Albendazole can be increased when combined with Aminoglutethimide. |
| Cephalexin | The metabolism of Cephalexin can be increased when combined with Aminoglutethimide. |
| Doxazosin | The metabolism of Doxazosin can be increased when combined with Aminoglutethimide. |
| Fenofibrate | The metabolism of Fenofibrate can be increased when combined with Aminoglutethimide. |
| Atazanavir | The metabolism of Atazanavir can be increased when combined with Aminoglutethimide. |
| Rosuvastatin | The metabolism of Rosuvastatin can be increased when combined with Aminoglutethimide. |
| Allylestrenol | The metabolism of Allylestrenol can be increased when combined with Aminoglutethimide. |
| Zuclopenthixol | The metabolism of Zuclopenthixol can be increased when combined with Aminoglutethimide. |
| Roflumilast | The metabolism of Roflumilast can be increased when combined with Aminoglutethimide. |
| Lacosamide | The metabolism of Lacosamide can be increased when combined with Aminoglutethimide. |
| Linagliptin | The metabolism of Linagliptin can be increased when combined with Aminoglutethimide. |
| Vorapaxar | The metabolism of Vorapaxar can be increased when combined with Aminoglutethimide. |
| Suvorexant | The metabolism of Suvorexant can be increased when combined with Aminoglutethimide. |
| Netupitant | The metabolism of Netupitant can be increased when combined with Aminoglutethimide. |
| Tasimelteon | The metabolism of Tasimelteon can be increased when combined with Aminoglutethimide. |
| Nintedanib | The metabolism of Nintedanib can be increased when combined with Aminoglutethimide. |
| Tenofovir alafenamide | The metabolism of Tenofovir alafenamide can be increased when combined with Aminoglutethimide. |
| Dihydroergocornine | The metabolism of Dihydroergocornine can be increased when combined with Aminoglutethimide. |
| Duvelisib | The metabolism of Duvelisib can be increased when combined with Aminoglutethimide. |
| Gilteritinib | The metabolism of Gilteritinib can be increased when combined with Aminoglutethimide. |
| 9-aminocamptothecin | The metabolism of 9-aminocamptothecin can be increased when combined with Aminoglutethimide. |
| Methylprednisone | The metabolism of Methylprednisone can be increased when combined with Aminoglutethimide. |
| Dihydroergocristine | The metabolism of Dihydroergocristine can be increased when combined with Aminoglutethimide. |
| Dihydroergocryptine | The metabolism of Dihydroergocryptine can be increased when combined with Aminoglutethimide. |
| Medical Cannabis | The metabolism of Medical Cannabis can be increased when combined with Aminoglutethimide. |
| Elexacaftor | The metabolism of Elexacaftor can be increased when combined with Aminoglutethimide. |
| Tazemetostat | The metabolism of Tazemetostat can be increased when combined with Aminoglutethimide. |
| Fosaprepitant | The metabolism of Fosaprepitant can be increased when combined with Aminoglutethimide. |
| Lefamulin | The metabolism of Lefamulin can be increased when combined with Aminoglutethimide. |
| Methysergide | The metabolism of Methysergide can be increased when combined with Aminoglutethimide. |
| Meperidine | The metabolism of Meperidine can be increased when combined with Aminoglutethimide. |
| Ebastine | The metabolism of Ebastine can be increased when combined with Aminoglutethimide. |
| Terfenadine | The metabolism of Terfenadine can be increased when combined with Aminoglutethimide. |
| Cisapride | The metabolism of Cisapride can be increased when combined with Aminoglutethimide. |
| Isavuconazole | The metabolism of Isavuconazole can be increased when combined with Aminoglutethimide. |
| Pretomanid | The metabolism of Pretomanid can be increased when combined with Aminoglutethimide. |
| Pimavanserin | The metabolism of Pimavanserin can be increased when combined with Aminoglutethimide. |
| Estetrol | The metabolism of Estetrol can be increased when combined with Aminoglutethimide. |
| Infigratinib | The metabolism of Infigratinib can be increased when combined with Aminoglutethimide. |
| Cyclosporine | The metabolism of Cyclosporine can be increased when combined with Aminoglutethimide. |
| Dofetilide | The metabolism of Dofetilide can be increased when combined with Aminoglutethimide. |
| Theophylline | The metabolism of Theophylline can be increased when combined with Aminoglutethimide. |