Oral, mouse: LD50 = 440 mg/kg; Oral, rat: LD50 = 763 mg/kg; Symptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting.
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Deferasirox | The serum concentration of Chlorzoxazone can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Chlorzoxazone can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Chlorzoxazone can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Chlorzoxazone can be decreased when it is combined with Teriflunomide. |
| Buprenorphine | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Hydrocodone | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Magnesium sulfate | The therapeutic efficacy of Chlorzoxazone can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Chlorzoxazone may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Mirtazapine | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Orphenadrine | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Pramipexole | Chlorzoxazone may increase the sedative activities of Pramipexole. |
| Ropinirole | Chlorzoxazone may increase the sedative activities of Ropinirole. |
| Rotigotine | Chlorzoxazone may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Chlorzoxazone. |
| Sodium oxybate | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Thalidomide | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Chlorzoxazone. |
| Mirabegron | The serum concentration of Chlorzoxazone can be increased when it is combined with Mirabegron. |
| Abiraterone | The serum concentration of Chlorzoxazone can be increased when it is combined with Abiraterone. |
| Cyproterone acetate | The metabolism of Chlorzoxazone can be increased when combined with Cyproterone acetate. |
| Ethanol | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone. |
| Citalopram | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Citalopram. |
| Trazodone | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Trazodone. |
| Sertraline | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Sibutramine. |
| Zimelidine | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Milnacipran. |
| Desvenlafaxine | The serum concentration of Chlorzoxazone can be increased when it is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Seproxetine. |
| Levomilnacipran | Chlorzoxazone may decrease the excretion rate of Levomilnacipran which could result in a higher serum level. |
| Indalpine | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Indalpine. |
| Alaproclate | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Alaproclate. |
| Trospium | The metabolism of Chlorzoxazone can be decreased when combined with Trospium. |
| Benzatropine | Benzatropine may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Cyproheptadine. |
| Propiomazine | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Propiomazine. |
| Propantheline | Chlorzoxazone may decrease the excretion rate of Propantheline which could result in a higher serum level. |
| Dicyclomine | Chlorzoxazone may decrease the excretion rate of Dicyclomine which could result in a higher serum level. |
| Maprotiline | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Maprotiline. |
| Tolterodine | Chlorzoxazone may decrease the excretion rate of Tolterodine which could result in a higher serum level. |
| Flavoxate | Chlorzoxazone may decrease the excretion rate of Flavoxate which could result in a higher serum level. |
| Tiotropium | Chlorzoxazone may decrease the excretion rate of Tiotropium which could result in a higher serum level. |
| Solifenacin | The metabolism of Solifenacin can be decreased when combined with Chlorzoxazone. |
| Pizotifen | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Pizotifen. |
| Fesoterodine | Chlorzoxazone may decrease the excretion rate of Fesoterodine which could result in a higher serum level. |
| Aclidinium | Chlorzoxazone may decrease the excretion rate of Aclidinium which could result in a higher serum level. |
| Umeclidinium | The metabolism of Umeclidinium can be decreased when combined with Chlorzoxazone. |
| Trimebutine | Chlorzoxazone may decrease the excretion rate of Trimebutine which could result in a higher serum level. |
| Imidafenacin | Chlorzoxazone may decrease the excretion rate of Imidafenacin which could result in a higher serum level. |
| Revefenacin | The metabolism of Revefenacin can be decreased when combined with Chlorzoxazone. |
| Propiverine | Chlorzoxazone may decrease the excretion rate of Propiverine which could result in a higher serum level. |
| Quetiapine | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Quetiapine. |
| Doxepin | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Doxepin. |
| Zopiclone | The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zopiclone. |
| Albendazole | The metabolism of Chlorzoxazone can be increased when combined with Albendazole. |
| Rifampin | The metabolism of Chlorzoxazone can be increased when combined with Rifampicin. |
| Carbamazepine | The metabolism of Chlorzoxazone can be increased when combined with Carbamazepine. |
| Primidone | The metabolism of Chlorzoxazone can be increased when combined with Primidone. |
| Caffeine | The metabolism of Chlorzoxazone can be decreased when combined with Caffeine. |
| Moxifloxacin | The metabolism of Chlorzoxazone can be decreased when combined with Moxifloxacin. |
| Lidocaine | The metabolism of Chlorzoxazone can be decreased when combined with Lidocaine. |
| Mexiletine | The metabolism of Chlorzoxazone can be decreased when combined with Mexiletine. |
| Alosetron | The metabolism of Chlorzoxazone can be decreased when combined with Alosetron. |
| Gatifloxacin | The metabolism of Chlorzoxazone can be decreased when combined with Gatifloxacin. |
| Simeprevir | The metabolism of Chlorzoxazone can be decreased when combined with Simeprevir. |
| Lobeglitazone | The metabolism of Chlorzoxazone can be decreased when combined with Lobeglitazone. |
| Pazufloxacin | The metabolism of Chlorzoxazone can be decreased when combined with Pazufloxacin. |
| Osilodrostat | The metabolism of Chlorzoxazone can be decreased when combined with Osilodrostat. |
| Duloxetine | The metabolism of Chlorzoxazone can be decreased when combined with Duloxetine. |
| Ritanserin | The metabolism of Chlorzoxazone can be decreased when combined with Ritanserin. |
| Venlafaxine | The risk or severity of CNS depression can be increased when Venlafaxine is combined with Chlorzoxazone. |
| Clobazam | The serum concentration of Chlorzoxazone can be increased when it is combined with Clobazam. |
| Clozapine | The serum concentration of Chlorzoxazone can be increased when it is combined with Clozapine. |
| Chlorpromazine | The metabolism of Chlorzoxazone can be decreased when combined with Chlorpromazine. |
| Tranylcypromine | The metabolism of Chlorzoxazone can be decreased when combined with Tranylcypromine. |
| Celecoxib | The metabolism of Chlorzoxazone can be decreased when combined with Celecoxib. |
| Metoprolol | The metabolism of Chlorzoxazone can be decreased when combined with Metoprolol. |
| Cimetidine | The metabolism of Chlorzoxazone can be decreased when combined with Cimetidine. |
| Chloroquine | The metabolism of Chlorzoxazone can be decreased when combined with Chloroquine. |
| Nicardipine | The metabolism of Chlorzoxazone can be decreased when combined with Nicardipine. |
| Fusidic acid | The metabolism of Chlorzoxazone can be decreased when combined with Fusidic acid. |
| Cholecalciferol | The metabolism of Chlorzoxazone can be decreased when combined with Cholecalciferol. |
| Perhexiline | The metabolism of Chlorzoxazone can be decreased when combined with Perhexiline. |
| Panobinostat | The metabolism of Chlorzoxazone can be decreased when combined with Panobinostat. |
| Vilazodone | The metabolism of Chlorzoxazone can be decreased when combined with Vilazodone. |