Buclizine is an antihistamine medication with both antiemetic and anticholinergic effects L6220, belonging to the piperazine derivative family of drugs. It was manufactured by Stuart Pharms and initially approved by the FDA in 1957.L6217 Following this, it was touted to be effective as an appetite stimulant in children when administered in the syrup form, however, this indication has not been validated.A178102 In addition to the above conditions, buclizine has been studied in the treatment of migraine attacks and in the treatment of nausea and vomiting during pregnancy. A178105, A178108
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aclidinium | The risk or severity of adverse effects can be increased when Buclizine is combined with Aclidinium. |
| Mianserin | Mianserin may increase the anticholinergic activities of Buclizine. |
| Mirabegron | The risk or severity of urinary retention can be increased when Buclizine is combined with Mirabegron. |
| Potassium chloride | The risk or severity of gastrointestinal ulceration can be increased when Buclizine is combined with Potassium chloride. |
| Pramlintide | The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Buclizine. |
| Secretin porcine | The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Buclizine. |
| Tiotropium | The risk or severity of adverse effects can be increased when Buclizine is combined with Tiotropium. |
| Topiramate | The risk or severity of hyperthermia and oligohydrosis can be increased when Buclizine is combined with Topiramate. |
| Umeclidinium | The risk or severity of adverse effects can be increased when Buclizine is combined with Umeclidinium. |
| Benzylpenicilloyl polylysine | Buclizine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent. |
| Betahistine | The therapeutic efficacy of Betahistine can be decreased when used in combination with Buclizine. |
| Glycopyrronium | The risk or severity of adverse effects can be increased when Buclizine is combined with Glycopyrronium. |
| Botulinum toxin type A | The risk or severity of adverse effects can be increased when Buclizine is combined with Botulinum toxin type A. |
| Glucagon | Buclizine may increase the gastrointestinal motility reducing activities of Glucagon. |
| Sulpiride | Buclizine may increase the anticholinergic activities of Sulpiride. |
| Botulinum toxin type B | The risk or severity of adverse effects can be increased when Buclizine is combined with Botulinum toxin type B. |
| Eluxadoline | The risk or severity of constipation can be increased when Buclizine is combined with Eluxadoline. |
| Ramosetron | The risk or severity of constipation can be increased when Buclizine is combined with Ramosetron. |
| Amphetamine | Amphetamine may decrease the sedative activities of Buclizine. |
| Phentermine | Phentermine may decrease the sedative activities of Buclizine. |
| Pseudoephedrine | Pseudoephedrine may decrease the sedative activities of Buclizine. |
| Benzphetamine | Benzphetamine may decrease the sedative activities of Buclizine. |
| Diethylpropion | Diethylpropion may decrease the sedative activities of Buclizine. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the sedative activities of Buclizine. |
| Mephentermine | Mephentermine may decrease the sedative activities of Buclizine. |
| MMDA | MMDA may decrease the sedative activities of Buclizine. |
| Midomafetamine | Midomafetamine may decrease the sedative activities of Buclizine. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Buclizine. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Buclizine. |
| Tenamfetamine | Tenamfetamine may decrease the sedative activities of Buclizine. |
| Chlorphentermine | Chlorphentermine may decrease the sedative activities of Buclizine. |
| Methylenedioxyethamphetamine | Methylenedioxyethamphetamine may decrease the sedative activities of Buclizine. |
| Dextroamphetamine | Dextroamphetamine may decrease the sedative activities of Buclizine. |
| Metamfetamine | Metamfetamine may decrease the sedative activities of Buclizine. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the sedative activities of Buclizine. |
| Ritobegron | Ritobegron may decrease the sedative activities of Buclizine. |
| Mephedrone | Mephedrone may decrease the sedative activities of Buclizine. |
| Methoxyphenamine | Methoxyphenamine may decrease the sedative activities of Buclizine. |
| Gepefrine | Gepefrine may decrease the sedative activities of Buclizine. |
| 2,5-Dimethoxy-4-ethylthioamphetamine | 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Buclizine. |
| Phendimetrazine | Phendimetrazine may decrease the sedative activities of Buclizine. |
| Naltrexone | The risk or severity of adverse effects can be increased when Buclizine is combined with Naltrexone. |
| Bezitramide | The risk or severity of adverse effects can be increased when Buclizine is combined with Bezitramide. |
| Tramadol | The risk or severity of adverse effects can be increased when Buclizine is combined with Tramadol. |
| Morphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Morphine. |
| Codeine | The risk or severity of adverse effects can be increased when Buclizine is combined with Codeine. |
| Hydromorphone | The risk or severity of adverse effects can be increased when Buclizine is combined with Hydromorphone. |
| Meperidine | The risk or severity of adverse effects can be increased when Buclizine is combined with Meperidine. |
| Oxycodone | The risk or severity of adverse effects can be increased when Buclizine is combined with Oxycodone. |
| Butorphanol | The risk or severity of adverse effects can be increased when Buclizine is combined with Butorphanol. |
| Dextropropoxyphene | The risk or severity of adverse effects can be increased when Buclizine is combined with Dextropropoxyphene. |
| Pentazocine | The risk or severity of adverse effects can be increased when Buclizine is combined with Pentazocine. |
| Sufentanil | The risk or severity of adverse effects can be increased when Buclizine is combined with Sufentanil. |
| Alfentanil | The risk or severity of adverse effects can be increased when Buclizine is combined with Alfentanil. |
| Fentanyl | The risk or severity of adverse effects can be increased when Buclizine is combined with Fentanyl. |
| Nalbuphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Nalbuphine. |
| Levorphanol | The risk or severity of adverse effects can be increased when Buclizine is combined with Levorphanol. |
| Remifentanil | The risk or severity of adverse effects can be increased when Buclizine is combined with Remifentanil. |
| Buprenorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Buprenorphine. |
| Hydrocodone | The risk or severity of adverse effects can be increased when Buclizine is combined with Hydrocodone. |
| Diphenoxylate | The risk or severity of adverse effects can be increased when Buclizine is combined with Diphenoxylate. |
| Oxymorphone | The risk or severity of adverse effects can be increased when Buclizine is combined with Oxymorphone. |
| Dezocine | The risk or severity of adverse effects can be increased when Buclizine is combined with Dezocine. |
| Methadyl acetate | The risk or severity of adverse effects can be increased when Buclizine is combined with Methadyl acetate. |
| Dihydroetorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Dihydroetorphine. |
| Diamorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Diamorphine. |
| Ethylmorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Ethylmorphine. |
| Etorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Etorphine. |
| Dextromoramide | The risk or severity of adverse effects can be increased when Buclizine is combined with Dextromoramide. |
| Desomorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Desomorphine. |
| Carfentanil | The risk or severity of adverse effects can be increased when Buclizine is combined with Carfentanil. |
| Dihydrocodeine | The risk or severity of adverse effects can be increased when Buclizine is combined with Dihydrocodeine. |
| Alphacetylmethadol | The risk or severity of adverse effects can be increased when Buclizine is combined with Alphacetylmethadol. |
| Dihydromorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Dihydromorphine. |
| Tapentadol | The risk or severity of urinary retention and constipation can be increased when Buclizine is combined with Tapentadol. |
| Ketobemidone | The risk or severity of adverse effects can be increased when Buclizine is combined with Ketobemidone. |
| DPDPE | The risk or severity of adverse effects can be increased when Buclizine is combined with DPDPE. |
| Lofentanil | The risk or severity of adverse effects can be increased when Buclizine is combined with Lofentanil. |
| Opium | The risk or severity of adverse effects can be increased when Buclizine is combined with Opium. |
| Normethadone | The risk or severity of adverse effects can be increased when Buclizine is combined with Normethadone. |
| Piritramide | The risk or severity of adverse effects can be increased when Buclizine is combined with Piritramide. |
| Alphaprodine | The risk or severity of adverse effects can be increased when Buclizine is combined with Alphaprodine. |
| Nicomorphine | The risk or severity of adverse effects can be increased when Buclizine is combined with Nicomorphine. |
| Meptazinol | The risk or severity of adverse effects can be increased when Buclizine is combined with Meptazinol. |
| Phenoperidine | The risk or severity of adverse effects can be increased when Buclizine is combined with Phenoperidine. |
| Phenazocine | The risk or severity of adverse effects can be increased when Buclizine is combined with Phenazocine. |
| Tilidine | The risk or severity of adverse effects can be increased when Buclizine is combined with Tilidine. |
| Carfentanil, C-11 | The risk or severity of adverse effects can be increased when Buclizine is combined with Carfentanil, C-11. |
| Methadone | The risk or severity of adverse effects can be increased when Buclizine is combined with Methadone. |
| Levacetylmethadol | The risk or severity of adverse effects can be increased when Buclizine is combined with Levacetylmethadol. |
| Benzhydrocodone | The risk or severity of adverse effects can be increased when Buclizine is combined with Benzhydrocodone. |
| Naloxegol | The risk or severity of adverse effects can be increased when Buclizine is combined with Naloxegol. |
| Trospium | The risk or severity of adverse effects can be increased when Trospium is combined with Buclizine. |
| Oxyphenonium | The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Buclizine. |
| Metixene | The risk or severity of adverse effects can be increased when Metixene is combined with Buclizine. |
| Trihexyphenidyl | The risk or severity of adverse effects can be increased when Buclizine is combined with Trihexyphenidyl. |
| Oxyphencyclimine | The risk or severity of adverse effects can be increased when Buclizine is combined with Oxyphencyclimine. |
| Procyclidine | The risk or severity of adverse effects can be increased when Buclizine is combined with Procyclidine. |
| Methscopolamine bromide | The risk or severity of adverse effects can be increased when Buclizine is combined with Methscopolamine bromide. |
| Darifenacin | The risk or severity of adverse effects can be increased when Buclizine is combined with Darifenacin. |